메뉴 건너뛰기




Volumn 24, Issue 5, 1996, Pages 449-459

Overview of enzymes of drug metabolism

Author keywords

Cytochrome P450; Drug metabolism; Genetic polymorphism; In vitro prediction; Induction; Interindividual variation

Indexed keywords

CYTOCHROME P450; DEXAMETHASONE; GLUTETHIMIDE; PHENACETIN; PHENAZONE; PHENOBARBITAL; PHENYTOIN; RIFAMPICIN; UNSPECIFIC MONOOXYGENASE;

EID: 0030426570     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02353473     Document Type: Review
Times cited : (208)

References (21)
  • 2
    • 0028074402 scopus 로고
    • The role of active metabolites in drug toxicity
    • M. Pirmohamed, N. R. Kitteringham, and B. K. Park. The role of active metabolites in drug toxicity. Drug Safety 11:114-144 (1994).
    • (1994) Drug Safety , vol.11 , pp. 114-144
    • Pirmohamed, M.1    Kitteringham, N.R.2    Park, B.K.3
  • 4
    • 0002635197 scopus 로고
    • The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms
    • W. Kalow (ed.), Pergamon, New York
    • U. A. Meyer, R. C. Skoda, U. M. Zanger, M. Heim, and F. Broly. The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms. In W. Kalow (ed.), Pharmacogenetics of Drug Metabolism, Pergamon, New York, 1992, pp. 609-623.
    • (1992) Pharmacogenetics of Drug Metabolism , pp. 609-623
    • Meyer, U.A.1    Skoda, R.C.2    Zanger, U.M.3    Heim, M.4    Broly, F.5
  • 5
    • 0028208792 scopus 로고
    • Pharmacogenetics: The slow, the rapid, and the ultrarapid
    • Commentary
    • U. A. Meyer. Commentary. Pharmacogenetics: The slow, the rapid, and the ultrarapid. Proc. Natl. Acad. Sci. U.S. 91:1983-1984 (1994).
    • (1994) Proc. Natl. Acad. Sci. U.S. , vol.91 , pp. 1983-1984
    • Meyer, U.A.1
  • 7
    • 0025080352 scopus 로고
    • Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification
    • M. Heim and U. A. Meyer. Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification. Lancet 336:529-532 (1990).
    • (1990) Lancet , vol.336 , pp. 529-532
    • Heim, M.1    Meyer, U.A.2
  • 8
    • 0029622336 scopus 로고
    • An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis
    • F. Broly, D. Marez, N. Sabbagh, M. Legrand, S. Millecamps, J.-M. Lo Guidice, P. Boone, and U. A. Meyer. An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis. Pharmacogenetics 5:373-384 (1995).
    • (1995) Pharmacogenetics , vol.5 , pp. 373-384
    • Broly, F.1    Marez, D.2    Sabbagh, N.3    Legrand, M.4    Millecamps, S.5    Lo Guidice, J.-M.6    Boone, P.7    Meyer, U.A.8
  • 10
    • 0028044085 scopus 로고
    • Identification of new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • S. M. F. De Morais, G. R. Wilkinson, J. Blaisdell, U. A. Meyer, K. Nakamura, and J. A. Goldstein. Identification of new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol. Pharmacol. 46:594-598 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 594-598
    • De Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3    Meyer, U.A.4    Nakamura, K.5    Goldstein, J.A.6
  • 11
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • U. A. Meyer and U. M. Zanger. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu. Rev. Pharmacol. Toxicol. 37: 269-296 (1997).
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 12
    • 0002030427 scopus 로고
    • Enzyme induction in the cytochrome P450 system
    • W. Kalow (ed.), Pergamon, New York
    • A. B. Okey. Enzyme induction in the cytochrome P450 system. In W. Kalow (ed.), Pharmacogenetics of Drug Metabolism, Pergamon, New York, 1992, pp. 549-608.
    • (1992) Pharmacogenetics of Drug Metabolism , pp. 549-608
    • Okey, A.B.1
  • 13
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P450 gene expression
    • D. J. Waxman and L. Azaroff. Phenobarbital induction of cytochrome P450 gene expression. Biochem. J. 281:577-592 (1992).
    • (1992) Biochem. J. , vol.281 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 14
    • 0027521742 scopus 로고
    • Mechanistic aspects of dioxin action
    • J. P. Whitlock, Jr. Mechanistic aspects of dioxin action. Chem. Res. Toxicol. 6:754-763 (1993).
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 754-763
    • Whitlock Jr., J.P.1
  • 15
    • 0028801475 scopus 로고
    • Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease
    • J. George, M. Murray, K. Byth, and G. C. Farrell. Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology 21:120-128 (1995).
    • (1995) Hepatology , vol.21 , pp. 120-128
    • George, J.1    Murray, M.2    Byth, K.3    Farrell, G.C.4
  • 16
    • 0020635141 scopus 로고
    • Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation
    • P. J. Meier, H. K. Mueller, B. Dick, and U. A. Meyer. Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology 85:682-692 (1993).
    • (1993) Gastroenterology , vol.85 , pp. 682-692
    • Meier, P.J.1    Mueller, H.K.2    Dick, B.3    Meyer, U.A.4
  • 17
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P450 of the P450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • T. Kronbach, V. Fischer, and U. A. Meyer. Cyclosporine metabolism in human liver: Identification of a cytochrome P450 of the P450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin. Pharmacol. Ther. 43:630-635 (1988).
    • (1988) Clin. Pharmacol. Ther. , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 18
    • 0024373348 scopus 로고
    • Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4
    • T. Kronbach, D. Mathys, M. Umeno, F. J. Gonzalez, and U. A. Meyer. Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol. Pharmacol. 36:89-96 (1989).
    • (1989) Mol. Pharmacol. , vol.36 , pp. 89-96
    • Kronbach, T.1    Mathys, D.2    Umeno, M.3    Gonzalez, F.J.4    Meyer, U.A.5
  • 20
    • 0022467917 scopus 로고
    • Oxidation of quinidine by human liver cytochrome P-450
    • F. P. Guengerich, D. Müller-Enoch, and I. A. Blair. Oxidation of quinidine by human liver cytochrome P-450. Mol. Pharmacol. 30:287-295 (1986).
    • (1986) Mol. Pharmacol. , vol.30 , pp. 287-295
    • Guengerich, F.P.1    Müller-Enoch, D.2    Blair, I.A.3
  • 21
    • 0023754383 scopus 로고
    • Xenobiotic and endobiotic inhibitors of cytochrome P450db1 function, the target of the debrisoquine/sparteine type polymorphism
    • R. Fonne-Pfister and U. A. Meyer. Xenobiotic and endobiotic inhibitors of cytochrome P450db1 function, the target of the debrisoquine/sparteine type polymorphism. Biochem. Pharmacol. 37:3829-3835 (1988).
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3829-3835
    • Fonne-Pfister, R.1    Meyer, U.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.