Pyrethroids: Cytotoxicity and induction of CYP isoforms in human hepatocytes

Drug Metabolism and Drug Interactions

Volumn 23, Issue 3-4, 2008, Pages 211-236

  Das, Parikshit C ^a   Streit, Timothy M ^b   Cao, Yan ^a   Rose, Randy L ^a   Cherrington, Nathan ^c   Ross, Matthew K ^b   Wallace, Andrew D ^a   Hodgson, Ernest ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

CYP isoforms; Cytotoxicity; Deltamethrin; HepG2 cells; Human hepatocytes; Induction; Permethrin; PXR SXR

Indexed keywords

ADENYLATE KINASE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 7; CYTOCHROME P450 1A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2B6; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DACTINOMYCIN; DELTAMETHRIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSECTICIDE; MESSENGER RNA; PERMETHRIN; PREGNANE X RECEPTOR; PYRETHROID; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 3A; ISOENZYME; NITRILE; STEROID RECEPTOR;

ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; TOXICOKINETICS; ADULT; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TOXICITY; TUMOR CELL CULTURE;

ADENYLATE KINASE; ADULT; CASPASE 3; CASPASE 7; CELL DEATH; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; INSECTICIDES; ISOENZYMES; NITRILES; PERMETHRIN; PYRETHRINS; RECEPTORS, STEROID; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 60749107273     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2008.23.3-4.211     Document Type: Article

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