The functional variant of the inhibitory Fcγ receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 54, Issue 12, 2006, Pages 3828-3837

  Radstake, Timothy R D J ^a   Franke, Barbara ^a   Wenink, Mark H ^a   Nabbe, Karin C A M ^a   Coenen, Marieke J H ^a   Welsing, Paco ^a   Bonvini, Ezio ^b   Koenig, Scott ^b   Van Den Berg, Wim B ^a   Barrera, Pilar ^a   Van Riel, Piet L C M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Analytical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; FC RECEPTOR; FC RECEPTOR IIB; FLUORESCEIN ISOTHIOCYANATE;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; JOINT DESTRUCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS;

ANTIGENS, CD; ARTHRITIS, RHEUMATOID; ARTHROGRAPHY; CYTOKINES; DENDRITIC CELLS; ENDOCYTOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; JOINTS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, IGG;

EID: 33845638327     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22275     Document Type: Article

References (49)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
2. Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 2002;99:351-8.
3. Salmon JE, Pricop L. Human receptors for immunoglobulin G: key elements in the pathogenesis of rheumatic disease [review]. Arthritis Rheum 2001;44:739-50.
4. Malbec O, Fridman WH, Daeron M. Negative regulation of hematopoietic cell activation and proliferation by Fc γ RIIB. Curr Top Microbiol Immunol 1999;244:13-27.
5. Qin D, Wu J, Vora KA, Ravetch JV, Szakal AK, Manser T, et al. Fc γ receptor IIB on follicular dendritic cells regulates the B cell recall response. J Immunol 2000;164:6268-75.
6. Bell D, Young JW, Banchereau J. Dendritic cells. Adv Immunol 1999;72:255-324.
7. Sutton B, Corper A, Bonagura V, Taussig M. The structure and origin of rheumatoid factors. Immunol Today 2000;21:177-83.
8. Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, et al. Deletion of fcγ receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med 1999;189:187-94.
9. Nandakumar KS, Andren M, Martinsson P, Bajtner E, Hellstrom S, Holmdahl R, et al. Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB. Eur J Immunol 2003;33:2269-77.
10. Van Lent P, Nabbe KC, Boross P, Blom AB, Roth J, Holthuysen A, et al. The inhibitory receptor FcγRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcγRI/III but also by efficient clearance and endocytosis of immune complexes. Am J Pathol 2003;163:1839-48.
11. Kleinau S, Martinsson P, Heyman B. Induction and suppression of collagen-induced arthritis is dependent on distinct fcγ receptors. J Exp Med 2000;191:1611-6.
12. Van Lent PL, van Vuuren AJ, Blom AB, Holthuysen AE, van de Putte LB, van de Winkel JG, et al. Role of Fc receptor γ chain in inflammation and cartilage damage during experimental antigen-induced arthritis. Arthritis Rheum 2000;43:740-52.
13. Highton J, Carlisle B, Palmer DG. Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 1995;102:541-6.
14. Shinohara S, Hirohata S, Inoue T, Ito K. Phenotypic analysis of peripheral blood monocytes isolated from patients with rheumatoid arthritis. J Rheumatol 1992;19:211-5.
15. Blom AB, Radstake TR, Holthuysen AE, Sloetjes AW, Pesman GJ, Sweep FG, et al. Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase. Arthritis Rheum 2003;48:1002-14.
16. Wijngaarden S, van Roon JA, Bijlsma JW, van de Winkel JG, Lafeber FP. Fcγ receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs. Rheumatology (Oxford) 2003;42:681-8.
17. Wijngaarden S, van de Winkel JG, Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA. A shift in the balance of inhibitory and activating Fcγ receptors on monocytes toward the inhibitory Fcγ receptor lib is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis Rheum 2004;50:3878-87.
18. Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, et al. Association of Fey receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic erythematosus in Japanese. Genes Immun 1999;1:53-60.
19. Kyogoku C, Dijstelbloem HM, Tsuchiya N, Hatta Y, Kato H, Yamaguchi A, et al. Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 2002;46:1242-54.
20. Morgan AW, Griffiths B, Ponchel F, Montague BM, Ali M, Gardner PP, et al. Fcγ receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. Arthritis Rheum 2000;43:2328-34.
21. Nieto A, Caliz R, Pascual M, Mataran L, Garcia S, Martin J. Involvement of Fcγ receptor IIIA genotypes in susceptibility to rheumatoid arthritis. Arthritis Rheum 2000;43:735-9.
22. Radstake TR, Petit E, Pierlot C, van de Putte LB, Cornelis F, Barrera P. Role of Fcγ receptors IIA, IIIA, and IIIB in susceptibility to rheumatoid arthritis. J Rheumatol 2003;30:926-33.
23. Chu ZT, Tsuchiya N, Kyogoku C, Ohashi J, Qian YP, Xu SB, et al. Association of Fey receptor lib polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 2004;63:21-7.
24. Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, et al. Association of Fcγ receptor lib and IIIb polymorphisms with susceptibility to systemic lupus erythem-atosus in Thais. Tissue Antigens 2003;61:374-83.
25. Floto RA, Clatworthy MR, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, et al. Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts. Nat Med 2005;11:1056-8.
26. Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, et al. FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum Mol Genet 2005;14:2881-92.
27. Li X, Wu J, Carter RH, Edberg JC, Su K, Cooper GS, et al. A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis Rheum 2003;48:3242-52.
28. Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002;168:5333-41.
29. Pettit AR, MacDonald KP, O'Sullivan B, Thomas R. Differentiated dendritic cells expressing nuclear RelB are predominantly located in rheumatoid synovial tissue perivascular mononuclear cell aggregates. Arthritis Rheum 2000;43:791-800.
30. Weyand CM, Goronzy JJ. Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci 2003;987:140-9.
31. Jongbloed SL, Lebre MC, Fraser AR, Gracie JA, Sturrock RD, Tak PP, et al. Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res Ther 2005;8:R15.
32. Radst́ake TR, Blom AB, Sloetjes AW, van Gorselen EO, Pesman GJ, Engelen L, et al. Increased FcγRII expression and aberrant tumour necrosis factor α production by mature dendritic cells from patients with active rheumatoid arthritis. Ann Rheum Dis 2004;63:1556-63.
33. Leung BP, Conacher M, Hunter D, McInnes IB, Liew FY, Brewer JM. A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation. J Immunol 2002;169:7071-7.
34. Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW. Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. J Clin Invest 2005;115:2914-23.
35. Dhodapkar KM, Kaufman JL, Ehlers M, Banerjee DK, Bonvini E, Koenig S, et al. Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc Natl Acad Sci U S A 2005;102:2910-5.
36. Radstake TR, van Lent PL, Pesman GJ, Blom AB, Sweep FG, Ronnelid J, et al. High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcγR triggering. Ann Rheum Dis 2004;63:696-702.
37. Radstake TR, van der Voort R, ten Brummelhuis M, de Waal Malefijt M, Looman M, Figdor CG, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis and regulation by Fc γ receptors. Ann Rheum Dis 2005;64:359-67.
38. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
39. Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44-8.
40. Sharp JT, Young DY, Bluhm GB, Brook A, Brower AC, Corbett M, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? Arthritis Rheum 1985;28:1326-35.
41. Radstake TR, Barrera P, Albers JM, Swinkels HL, van de Putte LB, van Riel PL. Familial vs sporadic rheumatoid arthritis (RA): a prospective study in an early RA inception cohort. Rheumatology (Oxford) 2000;39:267-73.
42. Van Strijp JA, van Kessel KP, van der Toi ME, Verhoef J. Complement-mediated phagocytosis of herpes simplex virus by granulocytes: binding or ingestion. J Clin Invest 1989;84:107-12.
43. Sahlin S, Hed J, Rundquist I. Differentiation between attached and ingested immune complexes by a fluorescence quenching cytofluorometric assay. J Immunol Methods 1983;60:115-24.
44. Van der Heijde DM, van Riel PL, van Leeuwen MA, van't Hof MA, van Rijswijk MH, van de Putte LB. Prognostic factors for radiographic damage and physical disability in early rheumatoid arthritis: a prospective follow-up study of 147 patients. Br J Rheumatol 1992;31:519-25.
45. Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, Barrera P, et al. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum 2004;50:999-1007.
46. Kalergis AM, Ravetch JV. Inducing tumor immunity through the selective engagement of activating Fey receptors on dendritic cells. J Exp Med 2002;195:1653-9.
47. Yajima K, Nakamura A, Sugahara A, Takai T. FcγRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol 2003;33:1020-9.
48. Smolen JS, Han C, Bala M, Maini RN, Kalden JR, van der Heijde D, et al for the ATTRACT Study Group. Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study. Arthritis Rheum 2005;52:1020-30.
49. Van den Berg WB, van Riel PL. Uncoupling of inflammation and destruction in rheumatoid arthritis: myth or reality? [editorial]. Arthritis Rheum 2005;52:995-9.