Expression, pharmacological profile, and functional coupling of A 2b receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20

Molecular Pharmacology

Volumn 67, Issue 6, 2005, Pages 2137-2147

  Gessi, Stefania ^a,b   Varani, Katia ^a,b   Merighi, Stefania ^a,b,d   Cattabriga, Elena ^a,b   Pancaldi, Cecilia ^a,b   Szabadkai, Youri ^a,b   Rizzuto, Rosario ^a,b   Klotz, Karl Norbert ^c   Leung, Edward ^d   Mac Lennan, Stephen ^f   Baraldi, Pier Giovanni ^a   Borea, Pier Andrea ^a,b,e  

^a UNIVERSITY OF FERRARA   (Italy)

^b Ctro Naz di Eccellenza per lo Sviluppo di Metodologie Innovative   (Italy)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d King Pharmaceuticals   (United States)

^e UNIVERSITY OF FERRARA   (Italy)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; CYCLIC AMP; MESSENGER RNA; N BENZO[1,3]DIOXOL 5 YL [2 [5 (1,3 DIPROPYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXYL]ACETAMIDE]; PHOSPHOLIPASE C; RADIOLIGAND; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; ACETAMIDE DERIVATIVE; ADENOSINE A2B RECEPTOR; N BENZO(1,3)DIOXOL 5 YL 2 (5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXY) ACETAMIDE; N-BENZO(1,3)DIOXOL-5-YL-2-(5-(2,6-DIOXO-1,3-DIPROPYL-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL)-1-METHYL-1H-PYRAZOL-3-YLOXY)-ACETAMIDE; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; BLOOD CELL; CELL LINE; DRUG BINDING; HUMAN; HUMAN CELL; LYMPHOCYTE; NEUTROPHIL; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; PROTEIN BINDING;

ACETAMIDES; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; PROTEIN BINDING; PURINES; PYRAZOLES; RECEPTOR, ADENOSINE A2B; RECOMBINANT PROTEINS;

EID: 21744443649     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.009225     Document Type: Article

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