Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 3, 2007, Pages 1246-1251

  Mustafa, S Jamal ^a   Nadeem, Ahmed ^a   Fan, Ming ^b   Zhong, Hongyan ^c   Belardinelli, Luiz ^c   Zeng, Dewan ^c  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c CV THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYL 1 PROPYL 8 [1 (3 TRIFLUOROMETHYLBENZYL) 1H PYRAZOL 4 YL] 3,7 DIHYDROPURINE 2,6 DIONE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE A2B RECEPTOR ANTAGONIST; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR STIMULATING AGENT; ALLERGEN; CVT 6883; MONTELUKAST; RAGWEED ANTIGEN; THEOPHYLLINE; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; INFLAMMATION; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAGWEED;

ADENOSINE; ADENOSINE MONOPHOSPHATE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADMINISTRATION, INHALATION; AEROSOLS; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED STRAINS; PLETHYSMOGRAPHY; PURINES; PYRAZOLES; RECEPTOR, ADENOSINE A2B;

EID: 33847159974     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.112250     Document Type: Article

References (35)

1. Ali S, Mustafa SJ, and Metzger WJ (1994) Adenosine receptor-mediated broncho-constriction and bronchial hyperresponsiveness in allergic rabbit model. Am J Physiol 266:L271-L277.
2. Bucchioni E, Csoma Z, Allegra L, Chung KF, Barnes PJ, and Kharitonov SA (2004) Adenosine 5′-monophosphate increases levels of leukotrienes in breath condensate in asthma. Respir Med 98:651-655.
3. Busse WW and Lemanske RF (2001) Asthma. N Engl J Med 344:350-362.
4. Clancy JP, Ruiz FE, and Sorscher EJ (1999) Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway. Am J Physiol 276:C361-C369.
5. Crimi N, Polosa R, and Mistretta A (1997) Purine derivatives in the study of allergic inflammation in respiratory diseases. Allergy 52:48-54.
6. Cushley MJ, Tattersfield AE, and Holgate ST (1983) Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol 15:161-165.
7. Driver AG, Kukoly CA, Ali S, and Mustafa SJ (1993) Adenosine in bronchoalveolar lavage fluid in asthma. Am Rev Respir Dis 148:91-97.
8. Fan M and Mustafa SJ (2002) Adenosine-mediated bronchoconstriction and lung inflammation in an allergic mouse model. Pulm Pharmacol Ther 15:147-155.
9. Fan M, Qin W, and Mustafa SJ (2003) Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. Am J Physiol 284:L1012-L1019.
10. Fan M and Mustafa SJ (2006) Role of adenosine in airway inflammation in an allergic mouse model of asthma. Int Immunopharmacol 6:36-45.
11. 2B receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Investig 96:1979-1986.
12. 2B receptor antagonist 3-isobutyl-8- pyrrolidinoxanthine (IPDX)(2). Biochem Pharmacol 62:1163-1173.
13. 2B) receptor as a novel therapeutic target in asthma. Br J Pharmacol 145:1009-1015.
14. Huszar E, Vass G, Vizi E, Csoma Z, Barat E, Molnar Vilagos G, Herjavecz I, and Horvath I (2002) Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur Respir J 20:1393-1398.
15. Justice JP, Shibata Y, Sur S, Mustafa SJ, Fan M, and Van Scott MR (2001) IL-10 gene knockout attenuates allergen-induced airway hyperresponsiveness in C57BL/6 mice. Am J Physiol 280:L363-L368.
16. Keir S, Boswell-Smith V, Spina D, and Page C (2006) Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. Br J Pharmacol 147:720-728.
17. Marquardt DL, Walker LL, and Heinemann S (1994) Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J Immunol 152:4508-4515.
18. Martin TJ and Broadley KJ (2002) Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways. Br J Pharmacol 137:729-738.
19. Mundell SJ, Olah ME, Panettieri RA, Benovic JL, and Penn RB (2001) Regulation of G protein-coupled receptor-adenyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine. Am J Respir Cell Mol Biol 24:155-163.
20. 2B receptor-mediated posttranscriptional mechanism. J Immunol 175:8260-8670.
21. Obiefuna PC, Batra VK, Nadeem A, Borron P, Wilson CN, and Mustafa SJ (2005) A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)- ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3, 7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. J Pharmacol Exp Ther 315:329-336.
22. Oldenburg PJ and Mustafa SJ (2005) Involvement of mast cells in adenosine-mediated bronchoconstriction and inflammation in an allergic mouse model. J Pharmacol Exp Ther 313:319-324.
23. Polosa R (2002) Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease. Eur Respir J 20:488-496.
24. Polosa R, Ng WH, Crimi N, Vancheri C, Holgate ST, Church MK, and Mistretta A (1995) Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. Am J Respir Crit Care Med 151:624-629.
25. 3 adenosine receptor is the unique adenosine receptor, which facilitates release of allergic mediators in mast cells. J Biol Chem 268:16887-16890.
26. 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 172:7726-7733.
27. Shryock JC and Belardinelli L (1997) Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology and pharmacology. Am J Cardiol 79:2-10.
28. Spicuzza L, Di Maria G, and Polosa R (2006) Adenosine in the airways: Implications and applications. Eur J Pharmacol 533:77-88.
29. 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Investig 116:2173-2182.
30. 3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. J Immunol 171:331-337.
31. 3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol 16:531-537.
32. 2B receptors in the regulation of TNF-alpha production by human monocytes. Biochem Pharmacol 69:883-889.
33. Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, and Zeng D (2004) A2B adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am J Respir Cell Mol Biol 30:118-125.
34. 2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol 32:2-8.
35. 2B adenosine receptors induce IL-19 from bronchial epithelial cells and results in TNF-α increase. Am J Respir Cell Mol Biol 35:587-592.