Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2131-2138

  Kim, Soon Ai ^a   Marshall, Melissa A ^b   Melman, Neli ^a   Kim, Hak Sung ^a   Müller, Christa E ^c   Linden, Joel ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALLYL 3 METHYL 8 PHENYLXANTHINE; 1 PROPYLXANTHINE; 3 (4 AMINO 3 IODOBENZYL) 8 (PHENYL 4 OXYACETATE) 1 PROPYLXANTHINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ADENOSINE A2B RECEPTOR ANTAGONIST; ANTIASTHMATIC AGENT; ANTIDIABETIC AGENT; ENPROFYLLINE; IODINE; PENTOXIFYLLINE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; CLONING, MOLECULAR; HUMANS; LIGANDS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2B; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINES;

EID: 0037161610     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0104318     Document Type: Article

References (37)

1. Molecular biology of recombinant adenosine receptors
2. Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines
3. 2A-adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: Characterization with radioligand binding and by activation of adenylate cyclase
4. 2B, prostacyclin and prostaglandin E2 receptors via a cholera toxin-sensitive mechanism in human erythroleukemia cells
5. 2B subtype) and P2-purinoceptors to the control of vascular tone in the rat isolated mesenteric arterial bed
6. 2B receptor
7. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells
8. 2B receptor
9. 2B adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia
10. 2B adenosine receptors
11. Potent antagonists for the Human Adenosine A2B receptor. Derivatives of the triazolotriazine adenosine receptor antagonist ZM241385 with high affinity
12. 2B receptors
13. Molecular characterization of recombinant human adenosine receptors
14. 2B adenosine receptors
15. 2B receptors
16. 2B adenosine receptors
17. 2B adenosine receptors
18. Caffeine analogues: Structure-activity relationships at adenosine receptors
19. Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions
20. 2-adenosine receptors
21. 8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: Further potent and selective antagonists for Al-adenosine receptors
22. 2 adenosine receptors
23. 1-adenosine receptors by aryl substituents
24. Analogues of caffeine and theophylline: Effect of structural alterations on affinity at adenosine receptors
25. Synthesis of paraxanthine analogues (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: Structureactivity relationships at adenosine receptors
26. 2B receptors: A novel therapeutic target in asthma?
27. Adenosine receptor ligands: Potential as therapeutic agents in asthma and COPD
28. 2B Adenosine Receptor Antagonist, Inhibits Degranuilation of Cultured Human but Not Murine Mast Cells
29. Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: Comparison with caffeine and 7-(2-chloroethyl)theophylline
30. Synthesis and characterization of potent ligands at human recombinant adenosine receptors
31. 2 adenosine receptors in human mast cells
32. q in human embryonic kidney 293 cells and HMC-1 mast cells
33. Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radiolabel binding by 50%
34. 6-phenylisopropyladenosine
35. 2 receptors in rat brain tissue
36. 3 adenosine receptor
37. 2-adenosine receptors