New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A2B adenosine receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3642-3645

  Esteve, Cristina ^a   Nueda, Arsenio ^a   Díaz, José Luis ^a   Beleta, Jorge ^a   Cárdenas, Alvaro ^a   Lozoya, Estrella ^a   Cadavid, Maria Isabel ^b   Loza, Maria Isabel ^b   Ryder, Hamish ^a   Vidal, Bernat ^a  

^a Almirall ^*  (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

A2B adenosine receptor antagonists; Asthma; Pyrrolopyrimidine; Sulfonamides

Indexed keywords

6 [4 [[4 (4 BROMOBENZYL)PIPERAZIN 1 YL]SULFONYL]PHENYL] 1,3 DIMETHYL 1H PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; BENZENESULFONAMIDE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; IC 50; NONHUMAN; PH MEASUREMENT; RAT; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

BINDING, COMPETITIVE; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; PYRIMIDINONES; RECEPTOR, ADENOSINE A2B; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33746774785     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.074     Document Type: Article

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