The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling 1

Biology of Reproduction

Volumn 80, Issue 2, 2009, Pages 384-391

  Kolthur Seetharam, Ullas ^a   Teerds, Katja ^b   De Rooij, Dirk G ^c,d   Wendling, Olivia ^h   McBurney, Michael ^e,f   Sassone Cors, Paolo ^g   Davidson, Irwin ^h,i  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF OTTAWA   (Canada)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

ⁱ CNRS   (France)

Author keywords

Follicle stimulating hormone; Gene regulation; Leydig cell; LH; Sertoli cell; Spermatogenesis; STAR; Testis; Testosterone

Indexed keywords

GONADORELIN; GONADOTROPIN; HISTONE DEACETYLASE; LUTEINIZING HORMONE; SIRTUIN 1; TESTOSTERONE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; GENE CONTROL; GENE LOCUS; HOMEOSTASIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE FERTILITY; MALE STERILITY; MEIOSIS; METABOLIC REGULATION; MOUSE; NONHUMAN; PACHYTENE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERMATOCYTE; SPERMATOGENESIS; TESTIS DEVELOPMENT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

ANIMALS; CELL DIFFERENTIATION; FERTILITY; GONADOTROPINS, PITUITARY; HISTONE DEACETYLASES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFERTILITY, MALE; LEYDIG CELLS; MALE; MICE; MICE, KNOCKOUT; SERTOLI CELLS; SIGNAL TRANSDUCTION; SIRTUINS; SPERMATOGENESIS; TESTOSTERONE;

MUS;

EID: 59949094204     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.070193     Document Type: Article

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