Targeted disruption of luteinizing hormone β-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 49, 2004, Pages 17294-17299

  Ma, Xiaoping ^a   Dong, Yanlan ^a   Matzuk, Martin M ^a   Kumar, T Rajendra ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Folliculogenesis; Gonads pituitary; Spermatogenesis; Testosterone

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; LUTEINIZING HORMONE BETA SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS LUTEUM; EMBRYO; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GENE EXPRESSION; HISTOLOGY; HORMONE ACTION; HYPOGONADISM; HYPOPLASIA; INFERTILITY; KNOCKOUT MOUSE; LEYDIG CELL; MALE; MOUSE; MUTANT; NEWBORN DISEASE; NONHUMAN; OVARY; OVARY FOLLICLE DEVELOPMENT; PERINATAL PERIOD; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; SPERMATID; STEROIDOGENESIS; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; FOLLICLE STIMULATING HORMONE; GONADS; HYPOGONADISM; INFERTILITY; LEYDIG CELLS; LUTEINIZING HORMONE, BETA SUBUNIT; MALE; MICE; MICE, KNOCKOUT; SERTOLI CELLS; STEROIDS;

ANIMALIA;

EID: 10344230978     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404743101     Document Type: Article

References (42)

1. Pierce, J. G. & Parsons, T. F. (1981) Annu. Rev. Biochem. 50, 465-495.
2. Bousfield, G. R., Perry, W. M. & Ward, D. N. (1994) in The Physiology of Reproduction, eds. Knobil, E. & Neill, J. D. (Raven, New York), pp. 1749-1792.
3. O'Shaughnessy, P. J., Baker, P., Sohnius, U., Haavisto, A. M., Charlton, H. M. & Huhtaniemi, I. (1998) Endocrinology 139, 1141-1146.
4. Pakarinen, P., Kimura, S., El-Gehani, F., Pelliniemi, L. J. & Huhtaniemi, I. (2002) Endocrinology 143, 4477-4482.
5. Saez, J. M., Perrard-Sapori, M. H., Chatelain, P. G., Tabone, E. & Rivarola, M. A. (1987) J. Steroid. Biochem. 27, 317-329.
6. Saez, J. M., Avallet, O., Lejeune, H. & Chatelain, P. G. (1991) Horm. Res. 36, 104-115.
7. Saez, J. M., Avallet, O., Naville, D., Perrard-Sapori, M. H. & Chatelain, P. G. (1989) Ann. N.Y. Acad. Sci. 564, 210-231.
8. Saez, J. M. (1994) Endocr. Rev. 15, 574-626.
9. Richards, J. S. (2001) Endocrinology 142, 2184-2193.
10. Richards, J. S., Russell, D. L., Ochsner, S., Hsieh, M., Doyle, K. H., Falender, A. E., Lo, Y. K. & Sharma, S. C. (2002) Recent Prog. Horm. Res. 57, 195-220.
11. Kumar, T. R., Wang, Y., Lu, N. & Matzuk, M. M. (1997) Nat. Genet. 15, 201-204.
12. Dierich, A., Sairam, M. R., Monaco, L., Fimia, G. M., Gansmuller, A., LeMeur, M. & Sassone-Corsi, P. (1998) Proc. Natl. Acad. Sci. USA 95, 13612-13617.
13. Abel, M. H., Wootton, A. N., Wilkins, V., Huhtaniemi, I., Knight, P. G. & Charlton, H. M. (2000) Endocrinology 141, 1795-1803.
14. Zhang, F. P., Poutanen, M., Wilbertz, J. & Huhtaniemi, I. (2001) Mol. Endocrinol. 15, 172-183.
15. Lei, Z. M., Mishra, S., Zou, W., Xu, B., Foltz, M., Li, X. & Rao, C. V. (2001) Mol. Endocrinol. 15, 184-200.
16. Aittomaki, K., Lucena, J. L., Pakarinen, P., Sistonen, P., Tapanainen, J., Gromoll, J., Kaskikari, R., Sankila, E. M., Lehvaslaiho, H., Engel, A. R., et al. (1995) Cell 82, 959-968.
17. Aittomaki, K., Herva, R., Stenman, U. H., Juntunen, K., Ylostalo, P., Hovatta, O. & de la Chapelle, A. (1996) J. Clin. Endocrinol. Metab. 81, 3722-3726.
18. Themmen, A. P. N. & Huhtaniemi, I. T. (2000) Endocr. Rev. 21, 551-583.
19. Themmen, A. P. & Verhoef-Post, M. (2002) Semin. Reprod. Med. 20, 199-204.
20. Weiss, J., Axelrod, L., Whitcomb, R. W., Harris, P. E., Crowley, W. F. & Jameson, J. L. (1992) N. Engl. J. Med. 326, 179-183.
21. Mason, A. J., Pitts, S. L., Nikolics, K., Szonyi, E., Wilcox, J. N., Seeburg, P. H. & Stewart, T. A. (1986) Science 234, 1372-1378.
22. Kendall, S. K., Samuelson, L. C., Saunders, T. L., Wood, R. I. & Camper, S. A. (1995) Genes Dev. 9, 2007-2019.
23. Kumar, T. R., Palapattu, G., Wang, P., Woodruff, T. K., Boime, I., Byrne, M. C. & Matzuk, M. M. (1999) Mol. Endocrinol. 13, 851-865.
24. Matzuk, M. M., Finegold, M. J., Su, J. G., Hsueh, A. J. & Bradley, A. (1992) Nature 360, 313-319.
25. Matzuk, M. M., DeMayo, F. J., Hadsell, L. A. & Kumar, T. R. (2003) Biol. Reprod. 69, 338-346.
26. Kumar, T. R., Fairchild-Huntress, V. & Low, M. J. (1992) Mol. Endocrinol. 6, 81-90.
27. O'Shaughnessy, P. J., Willerton, L. & Baker, P. J. (2002) Biol. Reprod. 66, 966-975.
28. Zhang, F. P., Pakarainen, T., Poutanen, M., Toppari, J. & Huhtaniemi, I. (2003) Proc. Natl. Acad. Sci. USA 100, 13692-13697.
29. Risma, K. A., Hirshfield, A. N. & Nilson, J. H. (1997) Endocrinology 138, 3540-3547.
30. Rulli, S. B., Kuorelahti, A., Karaer, O., Pelliniemi, L. J., Poutanen, M. & Huhtaniemi, I. (2002) Endocrinology 143, 4084-4095.
31. Rulli, S. B., Ahtiainen, P., Makela, S., Toppari, J., Poutanen, M. & Huhtaniemi, I. (2003) Endocrinology 144, 4980-4990.
32. Zhang, F. P., Pakarainen, T., Zhu, F., Poutanen, M. & Huhtaniemi, I. (2004) Endocrinology 145, 1453-1463.
33. Huhtaniemi, I. (1995) Reprod. Fertil. Dev. 7, 1025-1035.
34. Benton, L., Shan, L. X. & Hardy, M. P. (1995) J. Steroid. Biochem. Mol. Biol. 53, 61-68.
35. Habert, R., Lejeune, H. & Saez, J. M. (2001) Mol. Cell. Endocrinol. 179, 47-74.
36. Lejeune, H., Habert, R. & Saez, J. M. (1998) J. Mol. Endocrinol. 20, 1-25.
37. Holdcraft, R. W. & Braun, R. E. (2004) Development (Cambridge, U.K.) 131, 459-467.
38. Chang, C., Chen, Y. T., Yeh, S. D., Xu, Q., Wang, R. S., Guillou, F., Lardy, H. & Yeh, S. (2004) Proc. Natl. Acad. Sci. USA 101, 6876-6881.
39. He, W. W., Kumar, M. V. & Tindall, D. J. (1991) Nucleic Acids Res. 19, 2373-2378.
40. Csernus, V. (1986) Exp. Clin. Endocrinol. 88, 1-5.
41. Mannan, M. A. & O'Shaughnessy, P. J. (1991) J. Endocrinol. 130, 101-106.
42. Sokka, T. A., Hamalainen, T. M., Kaipia, A., Warren, D. W. & Huhtaniemi, I. T. (1996) Biol. Reprod. 55, 663-670.