DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

Nature

Volumn 390, Issue 6657, 1997, Pages 311-315

  Zazopoulos, Emmanuel ^a   Lalli, Enzo ^a   Stocco, Douglas M ^b   Sassone Corsi, Paolo ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ADRENAL HYPERPLASIA; ARTICLE; BINDING SITE; DNA BINDING; DNA TRANSCRIPTION; GENE CONTROL; GENE REPRESSION; PRIORITY JOURNAL; PROMOTER REGION; STEROIDOGENESIS;

ANIMALS; BASE SEQUENCE; COS CELLS; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; STEROIDS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030728417     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36899     Document Type: Article

References (25)

1. Zanaria, E. et al. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372, 635-641 (1994).
2. Muscatelli, F. et al. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypoganadotropic hypogonadism. Nature 372, 672-676 (1994).
3. Swain, A. et al. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nature Genet. 12, 404-409 (1996).
4. Ikeda, Y. et al. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development. Mol. Endocrinol. 10, 1261-1272 (1996).
5. Tamai, K. T. et al. Hormonal and developmental regulation of DAX-1 expression in Sertoli cells. Mol. Endocrinol. 10, 1561-1569 (1996).
6. Laudet, V., Stehelin, D. & Clevers, H. Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res. 21, 2493-2501 (1993).
7. Weir, H. M. et al. Structure of the HMG box motif in the B-domain of HMG-1. EMBO J. 12, 1311-1319 (1993).
8. Bianchi, M. E., Beltrame, M. & Paonessa, G. Specific recognition of cruciform DNA by nuclear protein HMG1. Science 243, 1056-1059 (1989).
9. Werner, M. H., Gronenborn, A. M. & Clore, M. G. Intercalation, DNA kinking, and the control of transcription. Science 271, 778-784 (1996).
10. Stocco, D. M. & Clark, B. J. Regulation of the acute production of steroids in steroidogenic cells. Endocr. Rev. 17, 221-244 (1996).
11. Clark, B. J., Wells, J., King, S. R. & Stocco, D. M. The purification, cloning and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. J. Biol. Chem. 269, 28314-28322 (1994).
12. Lin, D. et al. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267, 1828-1831 (1995).
13. Palecek, E. Local supercoil-stabilized DNA structures. Crit. Rev. Biochem. Mol. Biol. 26, 151-226 (1991).
14. Sugawara, T. et al. Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimualtes mitochondrial cholesterol 27-hydroxylase activity. Biochemsitry 34, 12506-12512 (1995).
15. Lalli, E. et al. A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita. Mol. Endocrinol. (in the press).
16. Schimmer, B. P. Adrenocortical Y1 cells. Meth. Enzymol. 58, 570-574 (1979).
17. Bose, H. S., Sugawara, T., Strauss, J. F. II & Miller, W. L. The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N. Engl. J. Med. 335, 1870-1878 (1996).
18. Caron, K. M. et al. Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein. Mol. Endocrinol. 11, 138-147 (1997).
19. Sugawara, T., Holt, J. A., Kiriakidou, M. & Strauss, J. F. III Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR)(gene. Biochemistry 35, 9052-9059 (1996).
20. Sinclair, A. H. et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346, 240-244 (1990).
21. Bardoni, B. et al. A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nature Genet. 7, 497-501 (1994).
22. Ito, M., Yu, R. & Jameson, J. L. DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita. Mol. Cell. Biol. 17, 1476-1483 (1997).
23. Clegg, C. H., Correll, L. A., Cadd, G. G. & McKnight, G. S. Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit. J. Biol. Chem. 262, 13111-13119 (1987).
24. Foulkes, N. S., Borrelli, E. & Sassone-Corsi, P. CREM gene: Use of alternative DNA binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64, 739-749 (1991).
25. Laoide, B. M., Foulkes, N. S., Schlotter, F. & Sassone-Corsi, P. The functional versatility of CREM is determined by its modular structure. EMBO J. 12, 1179-1191 (1993).