Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition

Archives of Toxicology

Volumn 82, Issue 12, 2008, Pages 909-921

  Westerink, Walter M A ^a   Stevenson, Joe C R ^a   Schoonen, Willem G E J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Aryl hydrocarbon receptor; Competition; CYP1A; H4IIE; HepG2; Induction

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; LIGAND; LUCIFERASE; POLYCHLORINATED BIPHENYL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; IC 50; LIVER CELL CARCINOMA; LIVER MICROSOME; LIVER TUMOR; METABOLISM; REPORTER GENE; TUMOR CELL LINE;

RATTUS;

ANIMALS; BINDING, COMPETITIVE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENES, REPORTER; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; LIVER NEOPLASMS; LUCIFERASES; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; RATS; RECEPTORS, ARYL HYDROCARBON; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

EID: 59849117420     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0317-7     Document Type: Article

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