Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes

Polish Journal of Pharmacology

Volumn 53, Issue 4, 2001, Pages 351-357

  Daniel, W A ^a   Syrek, M ^a   Rylko, Z ^a   Wojcikowski J ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Amitriptyline; Caffeine metabolism; Cytochrome; Fluoxetine; Imipramine; P 450 activity; Rat

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; FLUOXETINE; IMIPRAMINE; MARKER; N DEMETHYLASE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; LIVER MICROSOME; MALE; MEASUREMENT; NONHUMAN; PROTEIN FAMILY; RAT; REVIEW;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ARYL HYDROCARBON HYDROXYLASES; CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; FLUOXETINE; HYDROXYLATION; IMIPRAMINE; ISOENZYMES; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY;

EID: 0034749735     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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