JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes

Biochemical Pharmacology

Volumn 75, Issue 2, 2008, Pages 580-588

  Dvorak, Zdenek ^a   Vrzal, Radim ^a   Henklova, Pavla ^a   Jancova, Petra ^a   Anzenbacherova, Eva ^a   Maurel, Patrick ^b,c   Svecova, Lucie ^d   Pavek, Petr ^d   Ehrmann, Jiri ^a   Havlik, Roman ^a   Bednar, Petr ^a   Lemr, Karel ^a   Ulrichova, Jitka ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Aryl hydrocarbon receptor; c Jun N terminal kinase; Human hepatocytes; SP600125

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DIOXIN; MESSENGER RNA; PARTIAL AGONIST; RESVERATROL; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ADULT; AGED; ARTICLE; BIOTRANSFORMATION; DNA FLANKING REGION; DOSE RESPONSE; FEMALE; GENE INDUCTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLISM; PLASMID; PRIORITY JOURNAL; TRANSIENT TRANSFECTION;

ANTHRACENES; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MASS SPECTROMETRY; MICROSOMES, LIVER; PROTEIN KINASE INHIBITORS; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN;

EID: 37349124686     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.09.013     Document Type: Article

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