Glucocorticoid-Enhanced expression of dioxin target genes through regulation of the Rat aryl hydrocarbon receptor

Toxicological Sciences

Volumn 99, Issue 2, 2007, Pages 455-469

  Sonneveld, Edwin ^a   Jonas, Arjen ^a   Meijer, Onno C ^b   Brouwer, Abraham ^a   van der burg, Bart ^a  

^a BIODETECTION SYSTEMS B V   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Aryl hydrocarbon receptor; CALUX; Dioxin; Glucocorticoid receptor; Glucocorticoids

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUTATHIONE TRANSFERASE A1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ANIMAL CELL; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; BIOLOGICAL MODEL; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR AFFINITY; REGULATORY MECHANISM; REPORTER GENE; RISK ASSESSMENT; SPECIES DIFFERENCE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; MOLECULAR GENETICS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

RATTUS; RODENTIA;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

EID: 38449091780     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm176     Document Type: Article

References (50)

1. Abott, B. D. (1995). Review of the interaction between TCDD and glucocorticoids in embryonic palate. Toxicology 105, 365-373.
2. Almon, R. R., Lai, W., DuBois, D. C., and Jusko, W. J. (2005). Corticosteroidregulated genes in rat kidney: Mining time series array data. Am. J. Physiol. Endocrinol. Metab. 289, E870-E882.
3. Bamberger, C. M., Schulte, H. M., and Chrousos, G. P. (1996). Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr. Rev. 17, 245-261.
4. Behnisch, P. A., Hosoe, K., Brouwer, A., and Sakai, S. (2002). Screening of dioxin-like toxicity equivalents for various matrices with wild type and recombinant rat hepatoma H4IIe cells. Toxicol. Sci. 69, 125-130.
5. Brake, P. B., Zhang, L., and Jefcoate, C. R. (1998). Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: Evidence for transcriptional repression by glucocorticoids. Mol. Pharmacol. 54, 825-833.
6. Denison, M. S., Fischer, J. M., and Whitlock, J. P., Jr. (1988). The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. J. Biol. Chem. 263, 17221-17224.
7. Dumont, A., Hehner, S. P., Schmitz, M. L., Gustafsson, J. A., Liden, J., Okret, S., van der Saag, P. T., Wissink, S., van der Burg, B., Herrlich, P., et al. (1998). Cross-talk between steroids and NF-kappa B: What language? Trends Biochem. Sci. 23, 233-235.
8. Eguchi, H., Hayashi, S., Watanabe, J., Gotoh, O., and Kawajiri, K. (1994). Molecular cloning of the human AH receptor gene promoter. Biochem. Biophys. Res. Commun. 203, 615-622.
9. Fallone, F., Villard, P. H., Decome, L., Seree, E., Meo, M. D., Chacon, C., Durand, A., Barra, Y., and Lacarelle, B. (2005). PPARalpha activation potentiates AhR-induced CYP1A1 expression. Toxicology 216, 122-128.
10. Garrison, P. M., and Denison, M. S. (2000). Analysis of the murine AhR gene promoter. J. Biochem. Mol. Toxicol. 14, 1-10.
11. Garrison, P. M., Tullis, K., Aarts, M. M. J. G., Brouwer, A., Giesy, J. P., and Denison, M. S. (1996). Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30, 194-203.
12. Gu, Y. Z., Hogenesch, J. B., and Bradfield, C. A. (2000). The PAS superfamily: Sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40, 519-561.
13. Hankinson, O. (1995). The aryl hydrocarbon receptor complex. Pharmacol. Toxicol. 35, 307-340.
14. Harper, N., Wang, X., Liu, H., and Safe, S. (1994). Inhibition of estrogeninduced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Mol. Cell. Endocrinol. 104, 47-55.
15. Harper, P. A., Riddick, D. S., and Okey, A. B. (2006). Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor. Biochem. Pharmacol. 72, 267-279.
16. Hengstler, J. G., van der Burg, B., Steinberg, P., and Oesch, F. (1999). Interspecies differences in cancer susceptibility and toxicity. Drug. Metab. Rev. 31, 917-970.
17. Hoogenboom, L. A., Hamers, A. R., and Bovee, T. F. (1999). Bioassays for the detection of growth-promoting agents, veterinary drugs and environmental contaminants in food. Analyst 124, 79-85.
18. Jana, N. R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C., and Sone, H. (1999). Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochem. Biophys. Res. Commun. 256, 462-468.
19. Karchner, S. I., Franks, D. G., Kennedy, S. W., and Hahn, M. E. (2006). The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. U.S.A. 103, 6252-6257.
20. Kawakami, T., Ishimura, R., Nohara, K., Takeda, K., Tohyama, C., and Ohsako, S. (2006). Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor. Toxicol. Appl. Pharmacol. 212, 224-236.
21. Kharat, I., and Saatcioglu, F. (1996). Anti-estrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbonand estrogen-mediated signaling. J. Biol. Chem. 271, 10533-10537.
22. Kuil, C. W., Brouwer, A., van der Saag, P. T., and van der Burg, B. (1998). Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms. J. Biol. Chem. 273, 8829-8834.
23. Lai, K. P., Wong, M. H., and Wong, C. K. C. (2004). Modulation of AhRmediated CYP1A1 mRNA and EROD activities by 17b-estradiol and dexamethasone in TCDD-induced H4IIe cells. Toxicol. Sci. 78, 41-49.
24. Lahvis, G. P., and Bradfield, C. A. (1998). Ahr null alleles: Distinctive or different? Biochem. Pharmacol. 56, 781-787.
25. Linder, M. W., Falkner, K. C., Srinivasan, G., Hines, R. N., and Prough, R. A. (1999). Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the aryl hydrocarbon receptor. Drug Metab. Rev. 31, 247-271.
26. Livak, K. J., and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408.
27. Mathis, J. M., Houser, W. H., Bresnick, E., Cidlowski, J. A., Hines, R. N., Prough, R. A., and Simpson, E. R. (1989). Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I. Arch. Biochem. Biophys. 269, 93-105.
28. Matthews, J., and Gustafsson, J. A. (2006). Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl. Recept. Signal. 4, e016.
29. McKenna, N. J., and O' Malley, B. W. (2002). Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108 465-474.
30. Miller, A. G., Israel, D., and Whitlock, J. P., Jr. (1983). Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity. J. Biol. Chem. 258, 3523-3527.
31. Monostory, K., Kohalmy, K., Prough, R. A., Kobori, L., and Vereczkey, L. (2005). The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Lett. 579 229-235.
32. Nelson, C. C., Hendy, S. C., Shukin, R. J., Cheng, H., Bruchovsky, N., Koop, B. F., and Rennie, P. S. (1999). Determinants of DNA sequence specificity of the androgen, progesterone, and glucocorticoid receptors: Evidence for differential steroid receptor response elements. Mol. Endocrinol. 13, 2090-2107.
33. Ohtake, F., Takeyama, K., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., et al. (2003). Modulation of oestrogen receptor signaling by association with the activated dioxin receptor. Nature 423, 545-550.
34. Pinaire, J. A., Xiao, G. H., Falkner, K. C., and Prough, R. A. (2004). Regulation of NAD(P)H:qUinine oxidoreductase by glucocorticoids. Toxicol. Appl. Pharmacol. 199, 344-353.
35. Poland, A., and Glover, E. (1980). 2,3,7,8,-Tetrachlorodibenzo-p-dioxin: Segregation of toxicity with the Ah locus. Mol. Pharmacol. 17 86-94.
36. Poland, A., Palen, D., and Glover, E. (1994). Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 46, 915-921.
37. Pollenz, R. S., Sattler, C. A., and Poland, A. (1994). The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol. 45, 428-438.
38. Rogers, J. M., and Denison, M. S. (2002). Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol. Pharmacol. 61, 1393-1403.
39. Rushmore, T. H., and Kong, A. N. (2002). Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr. Drug Metab. 3, 481-490.
40. Safe, S. H. (1995). Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol. Ther. 67, 247-281.
41. Sherratt, A. J., Banet, D. E., and Prough, R. A. (1990). Glucocorticoid regulation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferases, and NAD(P)H:qUinine oxidoreductase in cultured fetal rat hepatocytes. Mol. Pharmacol. 37, 198-205.
42. Sonneveld, E., Jansen, H. J., Riteco, J. A., Brouwer, A., and van der Burg, B. (2005). Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid responsive bioassays. Toxicol. Sci. 83, 136-148.
43. Sugawara, T., Nomura, E., Sakuragi, N., and Fujimoto, S. (2001). The effect of the arylhydrocarbon receptor on the human steroidogenic acute regulatory gene promoter activity. J. Steroid Biochem. Mol. Biol. 78, 253-260.
44. Swanson, H. I., Chan, W. K., and Bradfield, C. A. (1995). DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J. Biol. Chem. 270, 26292-26302.
45. Tjian, Y., Ke, S., Denison, M. S., Rabson, A. B., and Gallo, M. A. (1999). Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem. 274, 510-515.
46. Vos, J. G., de Heer, C., and van Loveren, H. (1998). Immunotoxic effects of TCDD and toxic equivalency factors. Teratog. Carcinog. Mutagen. 17, 275-284.
47. Wiebel, F. J., and Cikryt, P. (1990). Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a timeconsuming process and associated with induction of the Ah receptor. Chem. Biol. Interact. 76, 307-320.
48. Xiao, G. H., Pinaire, J. A., Rodrigues, A. D., and Prough, R. A. (1995). Regulation of the Ah gene battery via Ah receptor-dependent and independent processes in cultured adult rat hepatocytes. Drug Metab. Dispos. 23, 642-650.
49. Yang, C., Boucher, F., Tremblay, A., and Michaud, J. L. (2004). Regulatory interaction between arylhydrocarbon receptor and SIM1, two basic helixloop-helix PAS proteins involved in the control of food intake. J. Biol. Chem. 279, 9306-9312.
50. Ziccardi, M. H., Gardner, I. A., and Denison, M. S. (2000). Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol. Sci. 54, 183-193.