-
1
-
-
0025949455
-
Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes
-
Back DJ and Tjia JF (1991) Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes. Br J Clin Pharmacol 32:624-626.
-
(1991)
Br J Clin Pharmacol
, vol.32
, pp. 624-626
-
-
Back, D.J.1
Tjia, J.F.2
-
2
-
-
0028970047
-
Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9
-
Baldwin SJ, Bloomer JC, Smith GJ, Ayrton AD, Clarke SE and Chenery RJ (1995) Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica 25:261-270.
-
(1995)
Xenobiotica
, vol.25
, pp. 261-270
-
-
Baldwin, S.J.1
Bloomer, J.C.2
Smith, G.J.3
Ayrton, A.D.4
Clarke, S.E.5
Chenery, R.J.6
-
4
-
-
0026981085
-
Regulation of cytochrome P4501A1 gene expression in a human intestinal cell line, CACO-2
-
Boulenc X, Bourriè M, Fabre I, Roque C, Joyeux H, Berger Y and Fabre G (1992) Regulation of cytochrome P4501A1 gene expression in a human intestinal cell line, CACO-2. J Pharmarol Exp Ther 263:1471-1478.
-
(1992)
J Pharmarol Exp Ther
, vol.263
, pp. 1471-1478
-
-
Boulenc, X.1
Bourriè, M.2
Fabre, I.3
Roque, C.4
Joyeux, H.5
Berger, Y.6
Fabre, G.7
-
5
-
-
0030430033
-
Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes
-
Bourrié M, Meunier V, Berger Y and Fabre G (1996) Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. J Pharmacol Exp Ther 277:321-332.
-
(1996)
J Pharmacol Exp Ther
, vol.277
, pp. 321-332
-
-
Bourrié, M.1
Meunier, V.2
Berger, Y.3
Fabre, G.4
-
6
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
7
-
-
0028106482
-
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
-
Burke MD, Thompson S, Weaver RJ, Wolf CR and Mayer RT (1994) Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 48:923-936.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 923-936
-
-
Burke, M.D.1
Thompson, S.2
Weaver, R.J.3
Wolf, C.R.4
Mayer, R.T.5
-
8
-
-
0015972948
-
A simple graphical method for determining the inhibition constants of mixed, uncompetitive, and non-competitive inhibitors
-
Cornish-Bowden A (1974) A simple graphical method for determining the inhibition constants of mixed, uncompetitive, and non-competitive inhibitors. Biochem J 137:143-144.
-
(1974)
Biochem J
, vol.137
, pp. 143-144
-
-
Cornish-Bowden, A.1
-
9
-
-
0027425282
-
Saccharomyces cerevisiae: An alternative source for human microsomal liver enzymes and its use in drug interaction studies
-
Eugster H-P and Sengstag C (1993) Saccharomyces cerevisiae: An alternative source for human microsomal liver enzymes and its use in drug interaction studies. Toxicology 82:61-73.
-
(1993)
Toxicology
, vol.82
, pp. 61-73
-
-
Eugster, H.-P.1
Sengstag, C.2
-
10
-
-
0025184860
-
Constitutive and inducible expression of human cytochrome P4501A1 in yeast Saccharomyces cerevisiae: An alternative enzyme source for in vitro studies
-
Eugster H-P, Sengstag C, Meyer UA, Hinnen A and Würgler FE (1990) Constitutive and inducible expression of human cytochrome P4501A1 in yeast Saccharomyces cerevisiae: An alternative enzyme source for in vitro studies. Biochem Biophys Res Commun 172:737-744.
-
(1990)
Biochem Biophys Res Commun
, vol.172
, pp. 737-744
-
-
Eugster, H.-P.1
Sengstag, C.2
Meyer, U.A.3
Hinnen, A.4
Würgler, F.E.5
-
11
-
-
0031024382
-
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Potential contribution to high first-pass metabolism
-
Fitzsimmons ME and Collins JM (1997) Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Potential contribution to high first-pass metabolism. Drug Metab Dispos 25:256-266.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 256-266
-
-
Fitzsimmons, M.E.1
Collins, J.M.2
-
12
-
-
84889229524
-
Effects of a chargrilled meat diet on human liver and intestinal CYP3A4 and CYP1A expression
-
Fontana RJ, Lown KS, Fortlage LA, Janardan SK, Adair CH and Watkins PB (1997) Effects of a chargrilled meat diet on human liver and intestinal CYP3A4 and CYP1A expression. Gastroenterology 112(Suppl):A875.
-
(1997)
Gastroenterology
, vol.112
, Issue.SUPPL.
-
-
Fontana, R.J.1
Lown, K.S.2
Fortlage, L.A.3
Janardan, S.K.4
Adair, C.H.5
Watkins, P.B.6
-
13
-
-
0029786432
-
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
-
Fromm MF, Busse D, Kroemer HK and Eichelbaum M (1996) Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 24:796-801.
-
(1996)
Hepatology
, vol.24
, pp. 796-801
-
-
Fromm, M.F.1
Busse, D.2
Kroemer, H.K.3
Eichelbaum, M.4
-
14
-
-
0031941137
-
Gut wall metabolism of verapamil in older people: Effects of rifampicin-mediated enzyme induction
-
Fromm MF, Dilger K, Busse D, Kroemer HK, Eichelbaum M and Klotz U (1998) Gut wall metabolism of verapamil in older people: Effects of rifampicin-mediated enzyme induction. Br J Clin Pharmacol 45:247-255.
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 247-255
-
-
Fromm, M.F.1
Dilger, K.2
Busse, D.3
Kroemer, H.K.4
Eichelbaum, M.5
Klotz, U.6
-
16
-
-
0028272001
-
Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins
-
Gonzalez FJ and Gelboin HV (1994) Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev 26:165-183.
-
(1994)
Drug Metab Rev
, vol.26
, pp. 165-183
-
-
Gonzalez, F.J.1
Gelboin, H.V.2
-
17
-
-
0002888510
-
Human cytochrome P450 enzymes
-
Ortiz de Montellano P ed, Plenum Press, New York
-
Guengerich FP (1995) Human cytochrome P450 enzymes, in Cytochrome P450: Structure, Mechanism, and Biochemistry (Ortiz de Montellano P ed) pp 473-535, Plenum Press, New York.
-
(1995)
Cytochrome P450: Structure, Mechanism, and Biochemistry
, pp. 473-535
-
-
Guengerich, F.P.1
-
18
-
-
0030030817
-
Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta
-
Hakkola J, Pasanen M, Hukkanen J, Pelkonen O, Mäenpää J, Edwards JR, Boobis AR and Raunio H (1996) Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol 51:403-411.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 403-411
-
-
Hakkola, J.1
Pasanen, M.2
Hukkanen, J.3
Pelkonen, O.4
Mäenpää, J.5
Edwards, J.R.6
Boobis, A.R.7
Raunio, H.8
-
19
-
-
0026457407
-
Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
-
Hebert MF, Roberts JP, Prueksaritanont T and Benet LZ (1992) Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther 52:453-457.
-
(1992)
Clin Pharmacol Ther
, vol.52
, pp. 453-457
-
-
Hebert, M.F.1
Roberts, J.P.2
Prueksaritanont, T.3
Benet, L.Z.4
-
20
-
-
0029972195
-
The nifedipinerifampin interaction: Evidence for induction of gut wall metabolism
-
Holtbecker N, Fromm MF, Kroemer HK, Ohnhaus EE and Heidemann H (1996) The nifedipinerifampin interaction: Evidence for induction of gut wall metabolism. Drug Metab Dispos 24:1121-1123.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 1121-1123
-
-
Holtbecker, N.1
Fromm, M.F.2
Kroemer, H.K.3
Ohnhaus, E.E.4
Heidemann, H.5
-
22
-
-
0028063131
-
CYP3A gene expression in human gut epithelium
-
Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM and Watkins PB (1994) CYP3A gene expression in human gut epithelium. Pharmacogenetics 4:247-259.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 247-259
-
-
Kolars, J.C.1
Lown, K.S.2
Schmiedlin-Ren, P.3
Ghosh, M.4
Fang, C.5
Wrighton, S.A.6
Merion, R.M.7
Watkins, P.B.8
-
24
-
-
0026782943
-
Induction of cytochrome P4501A genes (CYPIA) by omeprazole in the human alimentary tract
-
McDonnell WM, Scheiman JM and Traber PG (1992) Induction of cytochrome P4501A genes (CYPIA) by omeprazole in the human alimentary tract. Gastroenterology 103:1509-1516.
-
(1992)
Gastroenterology
, vol.103
, pp. 1509-1516
-
-
McDonnell, W.M.1
Scheiman, J.M.2
Traber, P.G.3
-
25
-
-
0031445547
-
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
-
Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, Perkins JD and Thummel KE (1997) Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther 283:1552-1562.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1552-1562
-
-
Paine, M.F.1
Khalighi, M.2
Fisher, J.M.3
Shen, D.D.4
Kunze, K.L.5
Marsh, C.L.6
Perkins, J.D.7
Thummel, K.E.8
-
26
-
-
0029738490
-
First-pass metabolism of midazolam by the human intestine
-
Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JP, Barr DM, Gillies BS and Thummel KE (1996) First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 60:14-24.
-
(1996)
Clin Pharmacol Ther
, vol.60
, pp. 14-24
-
-
Paine, M.F.1
Shen, D.D.2
Kunze, K.L.3
Perkins, J.D.4
Marsh, C.L.5
McVicar, J.P.6
Barr, D.M.7
Gillies, B.S.8
Thummel, K.E.9
-
27
-
-
0023743228
-
Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics
-
Pasanen M, Taskinen T, Iscan M, Sotaniemi EA, Kairaluoma M and Pelkonen O (1988) Inhibition of human hepatic and placental xenobiotic monooxygenases by imidazole antimycotics. Biochem Pharmacol 37:3861-3866.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 3861-3866
-
-
Pasanen, M.1
Taskinen, T.2
Iscan, M.3
Sotaniemi, E.A.4
Kairaluoma, M.5
Pelkonen, O.6
-
28
-
-
0028064672
-
Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: Substrate specificity with model substrates and promutagens
-
Penman BW, Chen L, Gelboin HV, Gonzalez FJ and Crespi CL (1994) Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: Substrate specificity with model substrates and promutagens. Carcinogenesis 15:1931-1937.
-
(1994)
Carcinogenesis
, vol.15
, pp. 1931-1937
-
-
Penman, B.W.1
Chen, L.2
Gelboin, H.V.3
Gonzalez, F.J.4
Crespi, C.L.5
-
29
-
-
0024604149
-
Cytochromes P-450 in the intestinal mucosa of man
-
Peters WHM and Kremers PG (1989) Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol 38:1535-1538.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1535-1538
-
-
Peters, W.H.M.1
Kremers, P.G.2
-
30
-
-
0029998275
-
Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells
-
Prueksaritanont T, Gorham LM, Hochman JH, Tran LO and Vyas KP (1996) Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells. Drug Metab Dispos 24:634-642.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 634-642
-
-
Prueksaritanont, T.1
Gorham, L.M.2
Hochman, J.H.3
Tran, L.O.4
Vyas, Kp.5
-
31
-
-
0015579498
-
A simplified method for the quantitative assay of small amounts of protein in biologic material
-
Schacterle GR and Pollack RL (1973) A simplified method for the quantitative assay of small amounts of protein in biologic material. Anal Biochem 51:654-655.
-
(1973)
Anal Biochem
, vol.51
, pp. 654-655
-
-
Schacterle, G.R.1
Pollack, R.L.2
-
34
-
-
0025364520
-
Differential expression and regulation of members of the cytochrome P4501A gene subfamily in human tissues
-
Sesardic D, Pasanen M, Pelkonen O and Boobis AR (1990) Differential expression and regulation of members of the cytochrome P4501A gene subfamily in human tissues. Carcinogenesis 11:1183-1188.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1183-1188
-
-
Sesardic, D.1
Pasanen, M.2
Pelkonen, O.3
Boobis, A.R.4
-
35
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y and Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
36
-
-
0030006119
-
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal livers and adult lungs
-
Shimada T, Yamazaki H, Mimura M, Wakamiya N, Ueng Y-F, Guengerich FP and Inui Y (1996) Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal livers and adult lungs. Drug Metab Dispos 24:515-522.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 515-522
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Wakamiya, N.4
Ueng, Y.-F.5
Guengerich, F.P.6
Inui, Y.7
-
37
-
-
0027077438
-
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens
-
Shimada T, Yun C-H, Yamazaki H, Gautier J-C, Beaune PH and Guengerich FP (1992) Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. Mol Pharmacol 41:856-864.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 856-864
-
-
Shimada, T.1
Yun, C.-H.2
Yamazaki, H.3
Gautier, J.-C.4
Beaune, P.H.5
Guengerich, F.P.6
-
38
-
-
0030015297
-
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
-
Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD and Wilkinson GR (1996) Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin Pharmacol Ther 59:491-502.
-
(1996)
Clin Pharmacol Ther
, vol.59
, pp. 491-502
-
-
Thummel, K.E.1
O'Shea, D.2
Paine, M.F.3
Shen, D.D.4
Kunze, K.L.5
Perkins, J.D.6
Wilkinson, G.R.7
-
39
-
-
0023588109
-
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
-
Watkins PB, Wrighton SA, Schuetz EG, Molowa DT and Guzelian PS (1987) Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 80:1029-1036.
-
(1987)
J Clin Invest
, vol.80
, pp. 1029-1036
-
-
Watkins, P.B.1
Wrighton, S.A.2
Schuetz, E.G.3
Molowa, D.T.4
Guzelian, P.S.5
-
40
-
-
0025225674
-
Immunochemical analysis of a cytochrome P-4501A1 homologue in human lung microsomes
-
Wheeler CW, Park SS and Guenther TM (1990) Immunochemical analysis of a cytochrome P-4501A1 homologue in human lung microsomes. Mol Pharmacol 38:634-643.
-
(1990)
Mol Pharmacol
, vol.38
, pp. 634-643
-
-
Wheeler, C.W.1
Park, S.S.2
Guenther, T.M.3
-
41
-
-
0022968547
-
Ethoxyresorufin O-deethylation by human liver microsomes
-
Williams FM, Mutch E, Woodhouse KW, Lambert D and Rawlins MD (1986) Ethoxyresorufin O-deethylation by human liver microsomes. Br J Clin Pharmacol 22:263-268.
-
(1986)
Br J Clin Pharmacol
, vol.22
, pp. 263-268
-
-
Williams, F.M.1
Mutch, E.2
Woodhouse, K.W.3
Lambert, D.4
Rawlins, M.D.5
-
42
-
-
0028361593
-
Inhibition of human CYP3A catalyzed 1′-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine
-
Wrighton SA and Ring BJ (1994) Inhibition of human CYP3A catalyzed 1′-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. Pharm Res (NY) 11:921-924.
-
(1994)
Pharm Res (NY)
, vol.11
, pp. 921-924
-
-
Wrighton, S.A.1
Ring, B.J.2
-
43
-
-
0026592561
-
Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity
-
Yang CS, Brady JF and Hong J-Y (1992) Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. FASEB J 6:737-744.
-
(1992)
FASEB J
, vol.6
, pp. 737-744
-
-
Yang, C.S.1
Brady, J.F.2
Hong, J.-Y.3
-
44
-
-
0031785065
-
Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavanoids
-
Zhai S, Dai R, Friedman FK and Vestal RE (1998) Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavanoids. Drug Metab Dispos 26:989-992.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 989-992
-
-
Zhai, S.1
Dai, R.2
Friedman, F.K.3
Vestal, R.E.4
|