-
1
-
-
0034796216
-
Isozyme-specific inhibitors and activators of protein kinase C
-
Schechtman D., and Mochly-Rosen D. Isozyme-specific inhibitors and activators of protein kinase C. Methods Enzymol 345 (2002) 470-489
-
(2002)
Methods Enzymol
, vol.345
, pp. 470-489
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
2
-
-
0242442127
-
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo
-
Inagaki K., Chen L., Ikeno F., Lee F.H., Imahashi K., Bouley D.M., Rezaee M., Yock P.G., Murphy E., and Mochly-Rosen D. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108 19 (2003) 2304-2307
-
(2003)
Circulation
, vol.108
, Issue.19
, pp. 2304-2307
-
-
Inagaki, K.1
Chen, L.2
Ikeno, F.3
Lee, F.H.4
Imahashi, K.5
Bouley, D.M.6
Rezaee, M.7
Yock, P.G.8
Murphy, E.9
Mochly-Rosen, D.10
-
3
-
-
0037443713
-
Peptide and protein drug delivery to and into tumors: challenges and solutions
-
Torchilin V.P., and Lukyanov A.N. Peptide and protein drug delivery to and into tumors: challenges and solutions. Drug Discov Today 8 6 (2003) 259-266
-
(2003)
Drug Discov Today
, vol.8
, Issue.6
, pp. 259-266
-
-
Torchilin, V.P.1
Lukyanov, A.N.2
-
4
-
-
5644276383
-
Delivery of bioactive molecules into the cell: the Trojan horse approach
-
Dietz G.P., and Bahr M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci 27 2 (2004) 85-131
-
(2004)
Mol Cell Neurosci
, vol.27
, Issue.2
, pp. 85-131
-
-
Dietz, G.P.1
Bahr, M.2
-
5
-
-
33845302976
-
Peptides targeting protein kinases: strategies and implications
-
Kaidanovich-Beilin O., and Eldar-Finkelman H. Peptides targeting protein kinases: strategies and implications. Physiology (Bethesda) 21 (2006) 411-418
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 411-418
-
-
Kaidanovich-Beilin, O.1
Eldar-Finkelman, H.2
-
6
-
-
0028239908
-
The third helix of the Antennapedia homeodomain translocates through biological membranes
-
Derossi D., Joliot A.H., Chassaing G., and Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 269 14 (1994) 10444-10450
-
(1994)
J Biol Chem
, vol.269
, Issue.14
, pp. 10444-10450
-
-
Derossi, D.1
Joliot, A.H.2
Chassaing, G.3
Prochiantz, A.4
-
7
-
-
0029982569
-
Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
-
Derossi D., Calvet S., Trembleau A., Brunissen A., Chassaing G., and Prochiantz A. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J Biol Chem 271 30 (1996) 18188-18193
-
(1996)
J Biol Chem
, vol.271
, Issue.30
, pp. 18188-18193
-
-
Derossi, D.1
Calvet, S.2
Trembleau, A.3
Brunissen, A.4
Chassaing, G.5
Prochiantz, A.6
-
8
-
-
0031759170
-
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
-
Nagahara H., Vocero-Akbani A.M., Snyder E.L., Ho A., Latham D.G., Lissy N.A., Becker-Hapak M., Ezhevsky S.A., and Dowdy S.F. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4 12 (1998) 1449-1452
-
(1998)
Nat Med
, vol.4
, Issue.12
, pp. 1449-1452
-
-
Nagahara, H.1
Vocero-Akbani, A.M.2
Snyder, E.L.3
Ho, A.4
Latham, D.G.5
Lissy, N.A.6
Becker-Hapak, M.7
Ezhevsky, S.A.8
Dowdy, S.F.9
-
9
-
-
0035542854
-
Molecular transporters for peptides: delivery of a cardioprotective epsilon PKC agonist peptide into cells and intact ischemic heart using a transport system, R(7)
-
Chen L., Wright L.R., Chen C.H., Oliver S.F., Wender P.A., and Mochly-Rosen D. Molecular transporters for peptides: delivery of a cardioprotective epsilon PKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol 8 12 (2001) 1123-1129
-
(2001)
Chem Biol
, vol.8
, Issue.12
, pp. 1123-1129
-
-
Chen, L.1
Wright, L.R.2
Chen, C.H.3
Oliver, S.F.4
Wender, P.A.5
Mochly-Rosen, D.6
-
10
-
-
0034021679
-
Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens
-
Oess S., and Hildt E. Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens. Gene Ther 7 9 (2000) 750-758
-
(2000)
Gene Ther
, vol.7
, Issue.9
, pp. 750-758
-
-
Oess, S.1
Hildt, E.2
-
11
-
-
0031423050
-
Cellular delivery of oligonucleotides by synthetic import peptide carrier
-
Dokka S., Toledo-Velasquez D., Shi X., Wang L., and Rojanasakul Y. Cellular delivery of oligonucleotides by synthetic import peptide carrier. Pharm Res 14 12 (1997) 1759-1764
-
(1997)
Pharm Res
, vol.14
, Issue.12
, pp. 1759-1764
-
-
Dokka, S.1
Toledo-Velasquez, D.2
Shi, X.3
Wang, L.4
Rojanasakul, Y.5
-
12
-
-
2642680830
-
Cell penetration by transportan
-
Pooga M., Hallbrink M., Zorko M., and Langel U. Cell penetration by transportan. Faseb J 12 1 (1998) 67-77
-
(1998)
Faseb J
, vol.12
, Issue.1
, pp. 67-77
-
-
Pooga, M.1
Hallbrink, M.2
Zorko, M.3
Langel, U.4
-
13
-
-
0031471203
-
Intercellular trafficking and protein delivery by a herpes virus structural protein
-
Elliott G., and O'Hare P. Intercellular trafficking and protein delivery by a herpes virus structural protein. Cell 88 2 (1997) 223-233
-
(1997)
Cell
, vol.88
, Issue.2
, pp. 223-233
-
-
Elliott, G.1
O'Hare, P.2
-
14
-
-
0026069024
-
Intranasal and intramuscular human calcitonin in female osteoporosis and in Paget's disease of bones: a pilot study
-
Pontiroli A.E., Pajetta E., Calderara A., Alberetto M., Pozza G., Manganelli V., Resmini G., Tessari L., and Maresca V. Intranasal and intramuscular human calcitonin in female osteoporosis and in Paget's disease of bones: a pilot study. J Endocrinol Investig 14 1 (1991) 47-51
-
(1991)
J Endocrinol Investig
, vol.14
, Issue.1
, pp. 47-51
-
-
Pontiroli, A.E.1
Pajetta, E.2
Calderara, A.3
Alberetto, M.4
Pozza, G.5
Manganelli, V.6
Resmini, G.7
Tessari, L.8
Maresca, V.9
-
15
-
-
29244433488
-
Use of transduction proteins to target trabecular meshwork cells: outflow modulation by profilin I
-
Gomez-Cabrero A., Comes N., Gonzalez-Linares J., de Lapuente J., Borras M., Pales J., Gual A., Gasull X., and Morales M. Use of transduction proteins to target trabecular meshwork cells: outflow modulation by profilin I. Mol Vis 11 (2005) 1071-1082
-
(2005)
Mol Vis
, vol.11
, pp. 1071-1082
-
-
Gomez-Cabrero, A.1
Comes, N.2
Gonzalez-Linares, J.3
de Lapuente, J.4
Borras, M.5
Pales, J.6
Gual, A.7
Gasull, X.8
Morales, M.9
-
16
-
-
37549056931
-
Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein
-
Johansson H.J., El-Andaloussi S., Holm T., Mae M., Janes J., Maimets T., and Langel U. Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein. Mol Ther 16 1 (2008) 115-123
-
(2008)
Mol Ther
, vol.16
, Issue.1
, pp. 115-123
-
-
Johansson, H.J.1
El-Andaloussi, S.2
Holm, T.3
Mae, M.4
Janes, J.5
Maimets, T.6
Langel, U.7
-
17
-
-
28444461040
-
Present and future of cell-penetrating peptide mediated delivery systems: "is the Trojan horse too wild to go only to Troy?"
-
Vives E. Present and future of cell-penetrating peptide mediated delivery systems: "is the Trojan horse too wild to go only to Troy?". J Control Release 109 1-3 (2005) 77-85
-
(2005)
J Control Release
, vol.109
, Issue.1-3
, pp. 77-85
-
-
Vives, E.1
-
18
-
-
0035474310
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
Schechtman D., and Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20 44 (2001) 6339-6347
-
(2001)
Oncogene
, vol.20
, Issue.44
, pp. 6339-6347
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
19
-
-
34250878954
-
Mechanisms of specificity in protein phosphorylation
-
Ubersax J.A., and Ferrell Jr. J.E. Mechanisms of specificity in protein phosphorylation. Nat Rev, Mol Cell Biol 8 7 (2007) 530-541
-
(2007)
Nat Rev, Mol Cell Biol
, vol.8
, Issue.7
, pp. 530-541
-
-
Ubersax, J.A.1
Ferrell Jr., J.E.2
-
20
-
-
0036682301
-
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
-
Nagar B., Bornmann W.G., Pellicena P., Schindler T., Veach D.R., Miller W.T., Clarkson B., and Kuriyan J. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res 62 15 (2002) 4236-4243
-
(2002)
Cancer Res
, vol.62
, Issue.15
, pp. 4236-4243
-
-
Nagar, B.1
Bornmann, W.G.2
Pellicena, P.3
Schindler, T.4
Veach, D.R.5
Miller, W.T.6
Clarkson, B.7
Kuriyan, J.8
-
21
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdeville R., Buchdunger E., Zimmermann J., and Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 1 7 (2002) 493-502
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.7
, pp. 493-502
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
-
22
-
-
0033392002
-
Tyrosine kinase inhibitors in preclinical development
-
Levitt M.L., and Koty P.P. Tyrosine kinase inhibitors in preclinical development. Invest New Drugs 17 3 (1999) 213-226
-
(1999)
Invest New Drugs
, vol.17
, Issue.3
, pp. 213-226
-
-
Levitt, M.L.1
Koty, P.P.2
-
23
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T., Bornmann W., Pellicena P., Miller W.T., Clarkson B., and Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289 5486 (2000) 1938-1942
-
(2000)
Science
, vol.289
, Issue.5486
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
24
-
-
0036791512
-
Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates
-
Williams D.H., and Mitchell T. Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates. Curr Opin Pharmacol 2 5 (2002) 567-573
-
(2002)
Curr Opin Pharmacol
, vol.2
, Issue.5
, pp. 567-573
-
-
Williams, D.H.1
Mitchell, T.2
-
25
-
-
0036295728
-
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
-
Yang J., Cron P., Thompson V., Good V.M., Hess D., Hemmings B.A., and Barford D. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9 6 (2002) 1227-1240
-
(2002)
Mol Cell
, vol.9
, Issue.6
, pp. 1227-1240
-
-
Yang, J.1
Cron, P.2
Thompson, V.3
Good, V.M.4
Hess, D.5
Hemmings, B.A.6
Barford, D.7
-
26
-
-
0011791776
-
In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase
-
Maller J.L., Kemp B.E., and Krebs E.G. In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A 75 1 (1978) 248-251
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, Issue.1
, pp. 248-251
-
-
Maller, J.L.1
Kemp, B.E.2
Krebs, E.G.3
-
27
-
-
0033622319
-
A genetically encoded, fluorescent indicator for cyclic AMP in living cells
-
Zaccolo M., De Giorgi F., Cho C.Y., Feng L., Knapp T., Negulescu P.A., Taylor S.S., Tsien R.Y., and Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol 2 1 (2000) 25-29
-
(2000)
Nat Cell Biol
, vol.2
, Issue.1
, pp. 25-29
-
-
Zaccolo, M.1
De Giorgi, F.2
Cho, C.Y.3
Feng, L.4
Knapp, T.5
Negulescu, P.A.6
Taylor, S.S.7
Tsien, R.Y.8
Pozzan, T.9
-
28
-
-
0035910074
-
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
-
Zhang J., Ma Y., Taylor S.S., and Tsien R.Y. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A 98 26 (2001) 14997-15002
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.26
, pp. 14997-15002
-
-
Zhang, J.1
Ma, Y.2
Taylor, S.S.3
Tsien, R.Y.4
-
29
-
-
0035909994
-
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
-
Ting A.Y., Kain K.H., Klemke R.L., and Tsien R.Y. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A 98 26 (2001) 15003-15008
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.26
, pp. 15003-15008
-
-
Ting, A.Y.1
Kain, K.H.2
Klemke, R.L.3
Tsien, R.Y.4
-
30
-
-
14044266297
-
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
-
Kunkel M.T., Ni Q., Tsien R.Y., Zhang J., and Newton A.C. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem 280 7 (2005) 5581-5587
-
(2005)
J Biol Chem
, vol.280
, Issue.7
, pp. 5581-5587
-
-
Kunkel, M.T.1
Ni, Q.2
Tsien, R.Y.3
Zhang, J.4
Newton, A.C.5
-
31
-
-
0037780971
-
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
-
Violin J.D., Zhang J., Tsien R.Y., and Newton A.C. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 161 5 (2003) 899-909
-
(2003)
J Cell Biol
, vol.161
, Issue.5
, pp. 899-909
-
-
Violin, J.D.1
Zhang, J.2
Tsien, R.Y.3
Newton, A.C.4
-
32
-
-
0022364057
-
Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase
-
Scott J.D., Fischer E.H., Demaille J.G., and Krebs E.G. Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 82 13 (1985) 4379-4383
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, Issue.13
, pp. 4379-4383
-
-
Scott, J.D.1
Fischer, E.H.2
Demaille, J.G.3
Krebs, E.G.4
-
33
-
-
0030249098
-
Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition
-
Tsigelny I., Grant B.D., Taylor S.S., and Ten Eyck L.F. Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition. Biopolymers 39 3 (1996) 353-365
-
(1996)
Biopolymers
, vol.39
, Issue.3
, pp. 353-365
-
-
Tsigelny, I.1
Grant, B.D.2
Taylor, S.S.3
Ten Eyck, L.F.4
-
34
-
-
0035144390
-
Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis
-
Li Y., van Kerkhof P., Marzolo M.P., Strous G.J., and Bu G. Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis. Mol Cell Biol 21 4 (2001) 1185-1195
-
(2001)
Mol Cell Biol
, vol.21
, Issue.4
, pp. 1185-1195
-
-
Li, Y.1
van Kerkhof, P.2
Marzolo, M.P.3
Strous, G.J.4
Bu, G.5
-
35
-
-
33750067972
-
Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition
-
Ilouz R., Kowalsman N., Eisenstein M., and Eldar-Finkelman H. Identification of novel glycogen synthase kinase-3beta substrate-interacting residues suggests a common mechanism for substrate recognition. J Biol Chem 281 41 (2006) 30621-30630
-
(2006)
J Biol Chem
, vol.281
, Issue.41
, pp. 30621-30630
-
-
Ilouz, R.1
Kowalsman, N.2
Eisenstein, M.3
Eldar-Finkelman, H.4
-
36
-
-
29244456731
-
Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle
-
Kaidanovich-Beilin O., and Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 316 1 (2006) 17-24
-
(2006)
J Pharmacol Exp Ther
, vol.316
, Issue.1
, pp. 17-24
-
-
Kaidanovich-Beilin, O.1
Eldar-Finkelman, H.2
-
37
-
-
0023764824
-
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
-
Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334 6184 (1988) 661-665
-
(1988)
Nature
, vol.334
, Issue.6184
, pp. 661-665
-
-
Nishizuka, Y.1
-
38
-
-
0023710193
-
Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase
-
Pearson R.B., Wettenhall R.E., Means A.R., Hartshorne D.J., and Kemp B.E. Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science 241 4868 (1988) 970-973
-
(1988)
Science
, vol.241
, Issue.4868
, pp. 970-973
-
-
Pearson, R.B.1
Wettenhall, R.E.2
Means, A.R.3
Hartshorne, D.J.4
Kemp, B.E.5
-
39
-
-
0024380329
-
Regulation of protein kinases by pseudosubstrate prototopes
-
Kemp B.E., Pearson R.B., House C., Robinson P.J., and Means A.R. Regulation of protein kinases by pseudosubstrate prototopes. Cell Signal 1 4 (1989) 303-311
-
(1989)
Cell Signal
, vol.1
, Issue.4
, pp. 303-311
-
-
Kemp, B.E.1
Pearson, R.B.2
House, C.3
Robinson, P.J.4
Means, A.R.5
-
40
-
-
0024413921
-
A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C
-
House C., Robinson P.J., and Kemp B.E. A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C. FEBS Lett 249 2 (1989) 243-247
-
(1989)
FEBS Lett
, vol.249
, Issue.2
, pp. 243-247
-
-
House, C.1
Robinson, P.J.2
Kemp, B.E.3
-
41
-
-
0024469531
-
Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope
-
Makowske M., and Rosen O.M. Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope. J Biol Chem 264 27 (1989) 16155-16159
-
(1989)
J Biol Chem
, vol.264
, Issue.27
, pp. 16155-16159
-
-
Makowske, M.1
Rosen, O.M.2
-
42
-
-
1842762897
-
Differential inhibition by alpha and epsilon PKC pseudosubstrate sequences: a putative mechanism for preferential PKC activation in neonatal cardiac myocytes
-
Johnson J.A. Differential inhibition by alpha and epsilon PKC pseudosubstrate sequences: a putative mechanism for preferential PKC activation in neonatal cardiac myocytes. Life Sci 74 25 (2004) 3153-3172
-
(2004)
Life Sci
, vol.74
, Issue.25
, pp. 3153-3172
-
-
Johnson, J.A.1
-
43
-
-
0042854721
-
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain
-
Craig A., Scott M., Burch L., Smith G., Ball K., and Hupp T. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep 4 8 (2003) 787-792
-
(2003)
EMBO Rep
, vol.4
, Issue.8
, pp. 787-792
-
-
Craig, A.1
Scott, M.2
Burch, L.3
Smith, G.4
Ball, K.5
Hupp, T.6
-
44
-
-
0033607522
-
The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo
-
Xu B., Wilsbacher J.L., Collisson T., and Cobb M.H. The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem 274 48 (1999) 34029-34035
-
(1999)
J Biol Chem
, vol.274
, Issue.48
, pp. 34029-34035
-
-
Xu, B.1
Wilsbacher, J.L.2
Collisson, T.3
Cobb, M.H.4
-
45
-
-
0035971144
-
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission
-
Bardwell A.J., Flatauer L.J., Matsukuma K., Thorner J., and Bardwell L. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem 276 13 (2001) 10374-10386
-
(2001)
J Biol Chem
, vol.276
, Issue.13
, pp. 10374-10386
-
-
Bardwell, A.J.1
Flatauer, L.J.2
Matsukuma, K.3
Thorner, J.4
Bardwell, L.5
-
46
-
-
0034653850
-
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
-
Enslen H., Brancho D.M., and Davis R.J. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. Embo J 19 6 (2000) 1301-1311
-
(2000)
Embo J
, vol.19
, Issue.6
, pp. 1301-1311
-
-
Enslen, H.1
Brancho, D.M.2
Davis, R.J.3
-
47
-
-
0042858567
-
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates
-
Ho D.T., Bardwell A.J., Abdollahi M., and Bardwell L. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem 278 35 (2003) 32662-32672
-
(2003)
J Biol Chem
, vol.278
, Issue.35
, pp. 32662-32672
-
-
Ho, D.T.1
Bardwell, A.J.2
Abdollahi, M.3
Bardwell, L.4
-
48
-
-
0033594480
-
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
-
Balendran A., Casamayor A., Deak M., Paterson A., Gaffney P., Currie R., Downes C.P., and Alessi D.R. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol 9 8 (1999) 393-404
-
(1999)
Curr Biol
, vol.9
, Issue.8
, pp. 393-404
-
-
Balendran, A.1
Casamayor, A.2
Deak, M.3
Paterson, A.4
Gaffney, P.5
Currie, R.6
Downes, C.P.7
Alessi, D.R.8
-
49
-
-
0033601217
-
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252
-
Balendran A., Currie R., Armstrong C.G., Avruch J., and Alessi D.R. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252. J Biol Chem 274 52 (1999) 37400-37406
-
(1999)
J Biol Chem
, vol.274
, Issue.52
, pp. 37400-37406
-
-
Balendran, A.1
Currie, R.2
Armstrong, C.G.3
Avruch, J.4
Alessi, D.R.5
-
50
-
-
2942673177
-
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death
-
Ferguson M., Luciani M.G., Finlan L., Rankin E.M., Ibbotson S., Fersht A., and Hupp T.R. The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death. Cell Cycle 3 1 (2004) 80-89
-
(2004)
Cell Cycle
, vol.3
, Issue.1
, pp. 80-89
-
-
Ferguson, M.1
Luciani, M.G.2
Finlan, L.3
Rankin, E.M.4
Ibbotson, S.5
Fersht, A.6
Hupp, T.R.7
-
51
-
-
9144221383
-
Sequence-based design of kinase inhibitors applicable for therapeutics and target identification
-
Niv M.Y., Rubin H., Cohen J., Tsirulnikov L., Licht T., Peretzman-Shemer A., Cna'an E., Tartakovsky A., Stein I., Albeck S., Weinstein I., Goldenberg-Furmanov M., Tobi D., Cohen E., Laster M., Ben-Sasson S.A., and Reuveni H. Sequence-based design of kinase inhibitors applicable for therapeutics and target identification. J Biol Chem 279 2 (2004) 1242-1255
-
(2004)
J Biol Chem
, vol.279
, Issue.2
, pp. 1242-1255
-
-
Niv, M.Y.1
Rubin, H.2
Cohen, J.3
Tsirulnikov, L.4
Licht, T.5
Peretzman-Shemer, A.6
Cna'an, E.7
Tartakovsky, A.8
Stein, I.9
Albeck, S.10
Weinstein, I.11
Goldenberg-Furmanov, M.12
Tobi, D.13
Cohen, E.14
Laster, M.15
Ben-Sasson, S.A.16
Reuveni, H.17
-
52
-
-
33845524054
-
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A
-
Saldanha S.A., Kaler G., Cottam H.B., Abagyan R., and Taylor S.S. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem 78 24 (2006) 8265-8272
-
(2006)
Anal Chem
, vol.78
, Issue.24
, pp. 8265-8272
-
-
Saldanha, S.A.1
Kaler, G.2
Cottam, H.B.3
Abagyan, R.4
Taylor, S.S.5
-
53
-
-
31944448448
-
Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents
-
Souza G.R., Christianson D.R., Staquicini F.I., Ozawa M.G., Snyder E.Y., Sidman R.L., Miller J.H., Arap W., and Pasqualini R. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci U S A 103 5 (2006) 1215-1220
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.5
, pp. 1215-1220
-
-
Souza, G.R.1
Christianson, D.R.2
Staquicini, F.I.3
Ozawa, M.G.4
Snyder, E.Y.5
Sidman, R.L.6
Miller, J.H.7
Arap, W.8
Pasqualini, R.9
-
54
-
-
0027495481
-
Recent advances in phage display
-
Barbas III C.F. Recent advances in phage display. Curr Opin Biotechnol 4 5 (1993) 526-530
-
(1993)
Curr Opin Biotechnol
, vol.4
, Issue.5
, pp. 526-530
-
-
Barbas III, C.F.1
-
55
-
-
0030752337
-
Phage display of combinatorial antibody libraries
-
Rader C., and Barbas III C.F. Phage display of combinatorial antibody libraries. Curr Opin Biotechnol 8 4 (1997) 503-508
-
(1997)
Curr Opin Biotechnol
, vol.8
, Issue.4
, pp. 503-508
-
-
Rader, C.1
Barbas III, C.F.2
-
56
-
-
0025917246
-
Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme
-
Mochly-Rosen D., Khaner H., Lopez J., and Smith B.L. Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme. J Biol Chem 266 23 (1991) 14866-14868
-
(1991)
J Biol Chem
, vol.266
, Issue.23
, pp. 14866-14868
-
-
Mochly-Rosen, D.1
Khaner, H.2
Lopez, J.3
Smith, B.L.4
-
57
-
-
0035839578
-
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C
-
Stebbins E.G., and Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. J Biol Chem 276 32 (2001) 29644-29650
-
(2001)
J Biol Chem
, vol.276
, Issue.32
, pp. 29644-29650
-
-
Stebbins, E.G.1
Mochly-Rosen, D.2
-
58
-
-
0030670399
-
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon
-
Csukai M., Chen C.H., De Matteis M.A., and Mochly-Rosen D. The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J Biol Chem 272 46 (1997) 29200-29206
-
(1997)
J Biol Chem
, vol.272
, Issue.46
, pp. 29200-29206
-
-
Csukai, M.1
Chen, C.H.2
De Matteis, M.A.3
Mochly-Rosen, D.4
-
59
-
-
0028938152
-
Localization of protein kinases by anchoring proteins: a theme in signal transduction
-
Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268 5208 (1995) 247-251
-
(1995)
Science
, vol.268
, Issue.5208
, pp. 247-251
-
-
Mochly-Rosen, D.1
-
60
-
-
0028801624
-
An autoregulatory region in protein kinase C: the pseudoanchoring site
-
Ron D., and Mochly-Rosen D. An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc Natl Acad Sci U S A 92 2 (1995) 492-496
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.2
, pp. 492-496
-
-
Ron, D.1
Mochly-Rosen, D.2
-
61
-
-
1942533628
-
A critical intramolecular interaction for protein kinase Cepsilon translocation
-
Schechtman D., Craske M.L., Kheifets V., Meyer T., Schechtman J., and Mochly-Rosen D. A critical intramolecular interaction for protein kinase Cepsilon translocation. J Biol Chem 279 16 (2004) 15831-15840
-
(2004)
J Biol Chem
, vol.279
, Issue.16
, pp. 15831-15840
-
-
Schechtman, D.1
Craske, M.L.2
Kheifets, V.3
Meyer, T.4
Schechtman, J.5
Mochly-Rosen, D.6
-
62
-
-
34047158112
-
Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide
-
Liron T., Chen L.E., Khaner H., Vallentin A., and Mochly-Rosen D. Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. J Mol Cell Cardiol 42 4 (2007) 835-841
-
(2007)
J Mol Cell Cardiol
, vol.42
, Issue.4
, pp. 835-841
-
-
Liron, T.1
Chen, L.E.2
Khaner, H.3
Vallentin, A.4
Mochly-Rosen, D.5
-
63
-
-
33747372839
-
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function
-
Kheifets V., Bright R., Inagaki K., Schechtman D., and Mochly-Rosen D. Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. J Biol Chem 281 32 (2006) 23218-23226
-
(2006)
J Biol Chem
, vol.281
, Issue.32
, pp. 23218-23226
-
-
Kheifets, V.1
Bright, R.2
Inagaki, K.3
Schechtman, D.4
Mochly-Rosen, D.5
-
64
-
-
9144256765
-
Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria
-
Murriel C.L., Churchill E., Inagaki K., Szweda L.I., and Mochly-Rosen D. Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem 279 46 (2004) 47985-47991
-
(2004)
J Biol Chem
, vol.279
, Issue.46
, pp. 47985-47991
-
-
Murriel, C.L.1
Churchill, E.2
Inagaki, K.3
Szweda, L.I.4
Mochly-Rosen, D.5
-
65
-
-
3843146318
-
Protein kinase C delta mediates cerebral reperfusion injury in vivo
-
Bright R., Raval A.P., Dembner J.M., Perez-Pinzon M.A., Steinberg G.K., Yenari M.A., and Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. J Neurosci 24 31 (2004) 6880-6888
-
(2004)
J Neurosci
, vol.24
, Issue.31
, pp. 6880-6888
-
-
Bright, R.1
Raval, A.P.2
Dembner, J.M.3
Perez-Pinzon, M.A.4
Steinberg, G.K.5
Yenari, M.A.6
Mochly-Rosen, D.7
-
66
-
-
0035949580
-
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC
-
Chen L., Hahn H., Wu G., Chen C.H., Liron T., Schechtman D., Cavallaro G., Banci L., Guo Y., Bolli R., Dorn II G.W., and Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci U S A 98 20 (2001) 11114-11119
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.20
, pp. 11114-11119
-
-
Chen, L.1
Hahn, H.2
Wu, G.3
Chen, C.H.4
Liron, T.5
Schechtman, D.6
Cavallaro, G.7
Banci, L.8
Guo, Y.9
Bolli, R.10
Dorn II, G.W.11
Mochly-Rosen, D.12
-
67
-
-
0033607301
-
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C
-
Chen C.H., Gray M.O., and Mochly-Rosen D. Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C. Proc Natl Acad Sci U S A 96 22 (1999) 12784-12789
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.22
, pp. 12784-12789
-
-
Chen, C.H.1
Gray, M.O.2
Mochly-Rosen, D.3
-
68
-
-
34250757608
-
Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function
-
Kheifets V., and Mochly-Rosen D. Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res 55 6 (2007) 467-476
-
(2007)
Pharmacol Res
, vol.55
, Issue.6
, pp. 467-476
-
-
Kheifets, V.1
Mochly-Rosen, D.2
-
70
-
-
33746381639
-
AKAP signaling complexes: getting to the heart of the matter
-
McConnachie G., Langeberg L.K., and Scott J.D. AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med 12 7 (2006) 317-323
-
(2006)
Trends Mol Med
, vol.12
, Issue.7
, pp. 317-323
-
-
McConnachie, G.1
Langeberg, L.K.2
Scott, J.D.3
-
71
-
-
0035794551
-
A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes
-
Newlon M.G., Roy M., Morikis D., Carr D.W., Westphal R., Scott J.D., and Jennings P.A. A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. Embo J 20 7 (2001) 1651-1662
-
(2001)
Embo J
, vol.20
, Issue.7
, pp. 1651-1662
-
-
Newlon, M.G.1
Roy, M.2
Morikis, D.3
Carr, D.W.4
Westphal, R.5
Scott, J.D.6
Jennings, P.A.7
-
72
-
-
0026680801
-
Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain
-
Carr D.W., Hausken Z.E., Fraser I.D., Stofko-Hahn R.E., and Scott J.D. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem 267 19 (1992) 13376-13382
-
(1992)
J Biol Chem
, vol.267
, Issue.19
, pp. 13376-13382
-
-
Carr, D.W.1
Hausken, Z.E.2
Fraser, I.D.3
Stofko-Hahn, R.E.4
Scott, J.D.5
-
73
-
-
0029802817
-
Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs
-
Hausken Z.E., Dell'Acqua M.L., Coghlan V.M., and Scott J.D. Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs. J Biol Chem 271 46 (1996) 29016-29022
-
(1996)
J Biol Chem
, vol.271
, Issue.46
, pp. 29016-29022
-
-
Hausken, Z.E.1
Dell'Acqua, M.L.2
Coghlan, V.M.3
Scott, J.D.4
-
74
-
-
38149061122
-
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design
-
Taylor S.S., Kim C., Cheng C.Y., Brown S.H., Wu J., and Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta 1784 1 (2008) 16-26
-
(2008)
Biochim Biophys Acta
, vol.1784
, Issue.1
, pp. 16-26
-
-
Taylor, S.S.1
Kim, C.2
Cheng, C.Y.3
Brown, S.H.4
Wu, J.5
Kannan, N.6
-
75
-
-
0037447227
-
Bioinformatics design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring
-
Alto N.M., Soderling S.H., Hoshi N., Langeberg L.K., Fayos R., Jennings P.A., and Scott J.D. Bioinformatics design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A 100 8 (2003) 4445-4450
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.8
, pp. 4445-4450
-
-
Alto, N.M.1
Soderling, S.H.2
Hoshi, N.3
Langeberg, L.K.4
Fayos, R.5
Jennings, P.A.6
Scott, J.D.7
-
76
-
-
0037389642
-
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism
-
Kammerer S., Burns-Hamuro L.L., Ma Y., Hamon S.C., Canaves J.M., Shi M.M., Nelson M.R., Sing C.F., Cantor C.R., Taylor S.S., and Braun A. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A 100 7 (2003) 4066-4071
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.7
, pp. 4066-4071
-
-
Kammerer, S.1
Burns-Hamuro, L.L.2
Ma, Y.3
Hamon, S.C.4
Canaves, J.M.5
Shi, M.M.6
Nelson, M.R.7
Sing, C.F.8
Cantor, C.R.9
Taylor, S.S.10
Braun, A.11
-
77
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
-
Bonny C., Oberson A., Negri S., Sauser C., and Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50 1 (2001) 77-82
-
(2001)
Diabetes
, vol.50
, Issue.1
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
78
-
-
0035313635
-
Industrial choices for protein production by large-scale cell culture
-
Chu L., and Robinson D.K. Industrial choices for protein production by large-scale cell culture. Curr Opin Biotechnol 12 2 (2001) 180-187
-
(2001)
Curr Opin Biotechnol
, vol.12
, Issue.2
, pp. 180-187
-
-
Chu, L.1
Robinson, D.K.2
-
79
-
-
0037102427
-
High-throughput method for the production and analysis of large natural product libraries for drug discovery
-
Eldridge G.R., Vervoort H.C., Lee C.M., Cremin P.A., Williams C.T., Hart S.M., Goering M.G., O'Neil-Johnson M., and Zeng L. High-throughput method for the production and analysis of large natural product libraries for drug discovery. Anal Chem 74 16 (2002) 3963-3971
-
(2002)
Anal Chem
, vol.74
, Issue.16
, pp. 3963-3971
-
-
Eldridge, G.R.1
Vervoort, H.C.2
Lee, C.M.3
Cremin, P.A.4
Williams, C.T.5
Hart, S.M.6
Goering, M.G.7
O'Neil-Johnson, M.8
Zeng, L.9
-
80
-
-
36549040859
-
The selectivity of protein kinase inhibitors: a further update
-
Bain J., Plater L., Elliott M., Shapiro N., Hastie C.J., McLauchlan H., Klevernic I., Arthur J.S., Alessi D.R., and Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J 408 3 (2007) 297-315
-
(2007)
Biochem J
, vol.408
, Issue.3
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shapiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
81
-
-
0034777139
-
Modeling parasite drug resistance: lessons for management and control strategies
-
Hastings I.M. Modeling parasite drug resistance: lessons for management and control strategies. Trop Med Int Health 6 11 (2001) 883-890
-
(2001)
Trop Med Int Health
, vol.6
, Issue.11
, pp. 883-890
-
-
Hastings, I.M.1
-
82
-
-
39449092458
-
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
-
Bates E., Bode C., Costa M., Gibson C.M., Granger C., Green C., Grimes K., Harrington R., Huber K., Kleiman N., Mochly-Rosen D., Roe M., Sadowski Z., Solomon S., and Widimsky P. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117 7 (2008) 886-896
-
(2008)
Circulation
, vol.117
, Issue.7
, pp. 886-896
-
-
Bates, E.1
Bode, C.2
Costa, M.3
Gibson, C.M.4
Granger, C.5
Green, C.6
Grimes, K.7
Harrington, R.8
Huber, K.9
Kleiman, N.10
Mochly-Rosen, D.11
Roe, M.12
Sadowski, Z.13
Solomon, S.14
Widimsky, P.15
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