Differential inhibition by α and εPKC pseudosubstrate sequences: A putative mechanism for preferential εPKC activation in neonatal cardiac myocytes

Life Sciences

Volumn 74, Issue 25, 2004, Pages 3153-3172

  Johnson, John A ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

and PKC; Arg C; Cardiac myocyte; Pseudosubstrates

Indexed keywords

ARGININE DERIVATIVE; ISOENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; RECOMBINANT ENZYME;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CELL LYSATE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MUSCLE FIBER CONTRACTION; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; ISOENZYMES; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-EPSILON; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

EID: 1842762897     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.11.016     Document Type: Article

References (32)

1. Bergman P.J., Gravitt K.R., O'Brien C.A. An N-myristoylated protein kinase C-alpha pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate. Cancer Chemotherapy Pharmacology. 40:1997;453-456.
2. Clark R.B., Friedman J., Johnson J.A., Kunkel M.W. β-adrenergic receptor desensitization of wild-type but not cyc- lymphoma cells unmasked by submillimolar Mg2+. FASEB Journal. 1:1987;289-297.
3. De B.P., Gupta S., Gupta S., Banergee A.K. Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication. Proceedings of the National Academy of Science USA. 92:1995;5204-5208.
4. Dutil E.M., Newton A.C. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. Journal of Biological Chemistry. 275:2000;10697-10701.
5. Edwards A.S., Newton A.C. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 36:1997;15615-15623.
6. Gailly P., Gong M.C., Somlyo A.V., Somlyo A.P. Possible role of atypical protein kinase C activated by arachidonic acid in Ca+2 sensitization of rabbit smooth muscle. Journal of Physiology. 500:1997;95-109.
7. Gray M.O., Karliner J.S., Mochly-Rosen D. A selective ε-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. Journal of Biological Chemistry. 272:1997;30945-30951.
8. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB Journal. 11:1997;649-669.
9. House C., Kemp B.E. Protein kinase C contains a pseudosubstrate prototype in its regulatory domain. Science. 238:1978;1726-1728.
10. James G., Olsen E.N. Deletion of the regulatory domain of protein kinase C α exposes regions in the hinge and catalytic domains that mediate nuclear targeting. Journal of Cell Biology. 116:1992;863-874.
11. Johnson J.A., Mochly-Rosen D. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the ε isozyme. Circulation Research. 76:1995;654-663.
12. Johnson J.A., Gray M.O., Chen C., Karliner J., Mochly-Rosen D. An improved method for the introduction of peptides into neonatal cardiac myocytes. Circulation Research. 79:1996;1086-1099.
13. Johnson J.A., Gray M.O., Chen C., Mochly-Rosen D. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. Journal of Biological Chemistry. 271:1996;24962-24966.
14. Klauck T.M., Faux M.C., Labudda K., Langeberg L.K., Jaken S., Scott J.D. Coordination of three signaling enzymes by AKAP 79, a mammalian scaffold protein. Science. 271:1996;1589-1592.
15. Laudanna C., Mochly-Rosen D., Liron T., Constantin G., Butcher E.C. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin dependent adhesion and chemotaxis. Journal of Biological Chemistry. 273:1998;30306-30315.
16. Lehel C., Olah Z., Jakab G., Anderson W.B. Protein kinase Cε is localized to the Golgi via its zinc finger domain and modulates golgi function. Proceedings of the National Academy of Science USA. 92:1995;1406-1410.
17. Majumdar S., Kane L.H., Rossi M.W., Volpp B.D., Nauseef W.M., Korchak H.M. Protein kinase C isotypes and signaling-transduction in human neutrophils:selective substrate specificity of calcium-dependent beta-PKC and novel calcium-independent nPKC. Biochimica Biophysica Acta. 1176:1993;276-286.
18. Mochly-Rosen D., Koshland D.E. Domain structure and phosphorylation of protein kinase C. Journal of Biological Chemistry. 262:1987;2291-2297.
19. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science. 268:1995;247-251.
20. Mochly-Rosen D., Gordon A. Anchoring proteins for protein kinase C:a means for isozyme-selectivity. FASEB Journal. 12:1998;35-42.
21. Nakanishi H., Brewer K.A., Exton J.H. Activation of the ζPKC isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate. Journal of Biological Chemistry. 268:1993;13-16.
22. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (London). 334:1988;661-665.
23. Noland T.A., Raynor R.L., Jideama N.M., Guo X., Kazanietz M.G., Blumberg P.M., Solaro R.J., Kuo J.F. Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry. 35:1996;14923-14931.
24. Orr J.W., Keranen L.M., Newton A.C. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. Journal of Biological Chemistry. 267:1992;15263-15266.
25. Ron D., Luo J., Mochly-Rosen D. C2 region-derived peptides inhibit translocation and function of (PKC in vivo. Journal of Biological Chemistry. 270:1995;1-8.
26. Sekiguchi K., Tsukuda M., Ojita K., Kikkawa U., Nishizuka Y. Three distinct forms of rat brain protein kinase C: differential response to unsaturated fatty acids. Biochemical Biophysical Research Communications. 145:1987;797-802.
27. Simpson P., Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Circulation Research. 50:1982;101-116.
28. Tang S.H., Sharp G.W.G. Atypical protein kinase C isozyme ζ mediates carbachol-stimulated insulin secretion in RINm5F cells. Diabetes. 47:1998;905-912.
29. Thiam K., Loing E., Zoukhri D., Rommens C., Hodges R., Dartt D., Verwaerde C., Auriault C., Gras-Masse H., Sergheraert C. Direct evidence of cyotplasmic delivery of PKC-α, -ε, and -ζ pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis. FEBS Letters. 459:1999;285-290.
30. Walker J.M., Homan E.C., Sando J.J. Differential activation of protein kinase C isozymes by short chain phosphatidylserines and phosphatidylcholines. Journal of Biological Chemistry. 265:1990;8016-8021.
31. Wooten M.W., Zhou G., Seibenhener M.L., Coleman E.S. A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells. Cell Growth and Differentiation. 5:1994;395-403.
32. Zoukhri D., Hodges R.R., Sergheraert C., Toker A., Darrt D. Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. American Journal of Physiology. 272(Cell Physiol. 41):1997;C263-C269.