Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 379, Issue 1, 2009, Pages 27-35

  Holownia, Adam ^a   Jablonski, Jakub ^a   Skiepko, Anna ^a   Mroz, Robert ^a   Sitko, Edyta ^a   Braszko, Jan J ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Acetaminophen; HepG2 cells; Intracellular Ca2+; Oxidative nitrosative stress; Ruthenium red; Ryanodine channel

Indexed keywords

4 METHYLPYRAZOLE; CALCIUM; CALCIUM CHANNEL; CYTOCHROME P450 2E1; N(G) NITROARGININE METHYL ESTER; PARACETAMOL; RUTHENIUM RED; RYANODINE; RYANODINE RECEPTOR; SUPEROXIDE DISMUTASE;

ARTICLE; CALCIUM TRANSPORT; CELL PROTECTION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; LIVER TOXICITY; MICROSOME; NITROSATIVE STRESS; OXIDATIVE STRESS; PROTEIN EXPRESSION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTIOXIDANTS; CALCIUM; CELL SURVIVAL; COLORING AGENTS; CYTOCHROME P-450 CYP2E1; HUMANS; MICROSOMES, LIVER; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRAZOLES; PYRROLIDINES; RUTHENIUM RED; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SUPEROXIDE DISMUTASE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 59449089045     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0343-2     Document Type: Article

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