The role of calcium in paracetamol (acetaminophen) cytotoxicity in PC12 cells transfected with CYP4502E1

Inflammopharmacology

Volumn 6, Issue 2, 1998, Pages 133-142

  Holownia, A ^a   Menez, J F ^a   Braszko, J J ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Acetaminophen; Cytochrome P4502E1; Intracellular Ca2+; Paracetamol; PC12 cells

Indexed keywords

CALCIUM; DIMETHYLNITROSAMINE DEMETHYLASE; DRUG METABOLITE; EGTAZIC ACID; N ACETYLIMIDOQUINONE; PARACETAMOL; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL CYCLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; GENETIC TRANSFECTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

EID: 0031876847     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-998-0030-4     Document Type: Article

References (22)

1. 1. PA Insel 1990 Analgesic-antipyretic and antiinflammatory agents: drugs employed in the treatment of rheumatoid arthritis and gout Gilman A Goodman TW Rall AS Nies P Taylor The Pharmacological Basis of Therapeutics Pergamon Press New York 638 81 Insel PA. Analgesic-antipyretic and antiinflammatory agents: drugs employed in the treatment of rheumatoid arthritis and gout. In: Goodman Gilman A, Rall TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. New York: Pergamon Press; 1990:638–81.
2. 2. CJ Patten PE Thomas RL Guy 1993 Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics Chem Res Toxicol. 6 511 18 8374050 10.1021/tx00034a019 1:CAS:528:DyaK3sXks1agt7c%3D Patten CJ, Thomas PE, Guy RL et al. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol. 1993;6:511–18.
3. 3. A Holownia J Mapoles JF Menez JJ Braszko 1997 Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1 J Mol Med. 75 522 7 9253715 10.1007/s001090050137 1:CAS:528:DyaK2sXlt1Wht7s%3D Holownia A, Mapoles J, Menez JF, Braszko JJ. Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1. J Mol Med. 1997;75:522–7.
4. 4. J Mapoles F Berthou A Alexander F Simon JF Menez 1993 Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression Eur J Biochem. 214 735 45 8391436 10.1111/j.1432-1033.1993.tb17975.x 1:CAS:528:DyaK3sXltFSjur8%3D Mapoles J, Berthou F, Alexander A, Simon F, Menez JF. Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression. Eur J Biochem. 1993;214:735–45.
5. 5. Y Day AI Cederbaum 1995 Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG32 cells J Pharmacol Exp Ther. 273 1 9 Day Y, Cederbaum AI. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG32 cells. J Pharmacol Exp Ther. 1995;273:1–9.
6. 6. JL Faber 1990 The role of calcium in lethal cell injury Chem Res Toxicol. 3 503 8 10.1021/tx00018a003 Faber JL. The role of calcium in lethal cell injury. Chem Res Toxicol. 1990;3:503–8.
7. 7. P Nicotera G Bellomo S Orrenius 1990 The role of Ca 2+ in cell killing Chem Res Toxicol. 3 484 94 2103319 10.1021/tx00018a001 1:CAS:528:DyaK3cXmtV2jtb8%3D Nicotera P, Bellomo G, Orrenius S. The role of Ca 2+ in cell killing. Chem Res Toxicol. 1990;3:484–94.
8. 8. P Nicotera G Bellomo S Orrenius 1992 Calcium-mediated mechanisms in chemically induced cell death Ann Rev Pharmacol Toxicol. 32 449 70 10.1146/annurev.pa.32.040192.002313 1:CAS:528:DyaK38XisV2qtrs%3D Nicotera P, Bellomo G, Orrenius S. Calcium-mediated mechanisms in chemically induced cell death. Ann Rev Pharmacol Toxicol. 1992;32:449–70.
9. 9. SD Ray CL Sorge A Tavacoli JL Raucy GB Corcoran 1991 Extensive alteration of genomic DNA and rise in nuclear Ca 2+ in vivo early after hepatotoxic acetaminophen overdose in mice Adv Exp Med Biol. 283 699 705 2069042 1:CAS:528:DyaK3MXlslCntL4%3D Ray SD, Sorge CL, Tavacoli A, Raucy JL, Corcoran GB. Extensive alteration of genomic DNA and rise in nuclear Ca 2+ in vivo early after hepatotoxic acetaminophen overdose in mice. Adv Exp Med Biol. 1991;283:699–705.
10. 10. W Shen MN Kamendulis SD Ray GB Corcoran 1991 Acetaminophen induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca 2+ accumulation and early DNA fragmentation with cell death Toxicol Appl Pharmacol. 111 245 54 10.1016/0041-008X(91)90028-D Shen W, Kamendulis MN, Ray SD, Corcoran GB. Acetaminophen induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca 2+ accumulation and early DNA fragmentation with cell death. Toxicol Appl Pharmacol. 1991;111:245–54.
11. 11. P Arslan F Virgilio Di M Beltrame RY Tsien T Pozzan 1985 Cytosolic Ca ++ homeostasis in Ehrlich and Yoshida carcinomas J Biol Chem. 260 2719 27 3919006 1:CAS:528:DyaL2MXhsVKqs78%3D Arslan P, Di Virgilio F, Beltrame M, Tsien RY, Pozzan T. Cytosolic Ca ++ homeostasis in Ehrlich and Yoshida carcinomas. J Biol Chem. 1985;260:2719–27.
12. 12. MM Bradford 1976 A rapid and sensitive method for the quantitation of the microgram quantities of protein utilizing the principle of protein dye-binding Anal Biochem. 72 248 54 942051 10.1016/0003-2697(76)90527-3 1:CAS:528:DyaE28XksVehtrY%3D Bradford MM. A rapid and sensitive method for the quantitation of the microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem. 1976;72:248–54.
13. 13. L Santella 1996 The cell nucleus: an eldorado to future calcium research Memb Biol. 153 83 92 10.1007/s002329900112 1:CAS:528:DyaK28Xlslent7g%3D Santella L. The cell nucleus: an eldorado to future calcium research. Memb Biol. 1996;153:83–92.
14. 14. N Masaki ME Kyle JL Farber 1989 Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids Archiv Biochem Biophys. 270 390 9 10.1016/0003-9861(89)90122-7 Masaki N, Kyle ME, Farber JL. Tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Archiv Biochem Biophys. 1989;270:390–9.
15. 15. HA Pollard F Dessi J Moreau F Lasbennes Y BenAri C Charriaut-Marlangue 1993 Regional variability in DNA fragmentation after global cerebral ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain J Neurochem. 61 1973 6 8229006 10.1111/j.1471-4159.1993.tb09843.x Pollard HA, Dessi F, Moreau J, Lasbennes F, BenAri Y, Charriaut-Marlangue C. Regional variability in DNA fragmentation after global cerebral ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain. J Neurochem. 1993;61:1973–6.
16. 16. SD Ray LM Kamendulis MW Gurule RD Yorkin GB Corcoran 1993 Ca ++ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen FASEB J. 7 453 63 8462787 1:CAS:528:DyaK3sXitVGit7s%3D Ray SD, Kamendulis LM, Gurule MW, Yorkin RD, Corcoran GB. Ca ++ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J. 1993;7:453–63.
17. 17. MA Barry JE Reynolds A Eastman 1993 Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification Cancer Res. 53 Suppl. 10 2349 57 8387392 1:CAS:528:DyaK3sXkvFaitLo%3D Barry MA, Reynolds JE, Eastman A. Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res. 1993;53(Suppl. 10):2349–57.
18. 18. DM Ojcius A Zychlinski LM Zheng JD Young 1991 Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes Exp Cell Res. 197 43 9 1915662 10.1016/0014-4827(91)90477-C 1:CAS:528:DyaK3MXmsFaqtrY%3D Ojcius DM, Zychlinski A, Zheng LM, Young JD. Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp Cell Res. 1991;197:43–9.
19. 19. DL McConkey P Hartzell SK Duddy 1988 2,3,7,8-Tetrachloro-dibenzo-p-dioxin kills immature thymocytes by Ca 2+-mediated endonuclease activation Science. 242 256 9 3262923 10.1126/science.3262923 1:CAS:528:DyaL1cXmtVKntrY%3D McConkey DL, Hartzell P, Duddy SK. 2,3,7,8-Tetrachloro-dibenzo-p-dioxin kills immature thymocytes by Ca 2+-mediated endonuclease activation. Science. 1988;242:256–9.
20. 20. RS Freeman S Estus EM Johnson 1994 Analysis of cell-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death Neuron. 12 343 55 8110463 10.1016/0896-6273(94)90276-3 1:CAS:528:DyaK2cXis1Kltbs%3D Freeman RS, Estus S, Johnson EM. Analysis of cell-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron. 1994;12:343–55.
21. 21. JE Schellmeyer 1988 Calpain II involvement in mitosis Science. 240 911 13 10.1126/science.2834825 Schellmeyer JE. Calpain II involvement in mitosis. Science. 1988;240:911–13.
22. 22. MKT Squier ACK Miller AM Malkinson JJ Cohen 1994 Calpain activation in apoptosis J Physiol. 159 229 37 1:CAS:528:DyaK2cXjtF2qu7o%3D Squier MKT, Miller ACK, Malkinson AM, Cohen JJ. Calpain activation in apoptosis. J Physiol. 1994;159:229–37.