Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity

Toxicology

Volumn 191, Issue 2-3, 2003, Pages 179-187

  Lewerenz, Virginia ^a   Hanelt, Sabine ^a   Nastevska, Cathrin ^a   El Bahay, Claudia ^a   Röhrdanz, Elke ^a   Kahl, Regine ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Acetaminophen; Catalase; Comet assay; DNA strand breaks; Hepatocytes; Malondialdehyde; MnSOD; N acetylcysteine; Silibin; Tocopherol

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; CATALASE; CHEMICAL COMPOUND; GLUTATHIONE; MALONALDEHYDE; MESSENGER RNA; PARACETAMOL; POLYPHENOL; RETINOL; SILIBININ; ANALGESIC AGENT; FORMAZAN; LIPID PEROXIDE; MTT FORMAZAN; NEUTRAL RED; RNA; SILYMARIN; TETRAZOLIUM;

ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DOSE RESPONSE; EXPERIMENT; LIVER CELL; MALE; MEASUREMENT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RAT STRAIN; ANIMAL; CELL DEATH; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; GENETICS; LIVER DISEASE; METABOLISM; NORTHERN BLOTTING; WISTAR RAT;

ACETAMINOPHEN; ACETYLCYSTEINE; ALPHA-TOCOPHEROL; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; BLOTTING, NORTHERN; CELL DEATH; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMAZANS; HEPATOCYTES; LIPID PEROXIDES; LIVER DISEASES; MALE; NEUTRAL RED; RATS; RATS, WISTAR; RNA; SILYMARIN; TETRAZOLIUM SALTS;

EID: 0142025010     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(03)00256-7     Document Type: Article

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