Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

Toxicology and Applied Pharmacology

Volumn 234, Issue 3, 2009, Pages 326-338

  Larosche, Isabelle ^a,b   Choumar, Amal ^a,b   Fromenty, Bernard ^a,b   Lettéron, Philippe ^a,b   Abbey Toby, Adjé ^a,b   Van Remmen, Holly ^c   Epstein, Charles J ^d   Richardson, Arlan ^c   Feldmann, Gérard ^a,b   Pessayre, Dominique ^a,b   Mansouri, Abdellah ^a,b  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol; Liver; Manganese superoxide dismutase; Mitochondria; Oxidative stress

Indexed keywords

ALCOHOL; CARBONYL DERIVATIVE; CATALASE; CYTOCHROME C OXIDASE; CYTOCHROME P450 2E1; DRINKING WATER; GLUTATHIONE PEROXIDASE; IRON; IRON CHELATING AGENT; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESPIRATORY COMPLEX V; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANTIOXIDANT ACTIVITY; ARTICLE; CYTOSOL; GENE OVEREXPRESSION; LIPID PEROXIDATION; LITTERMATE; LONG TERM EXPOSURE; MITOCHONDRIAL DNA DEPLETION; PEROXISOME; POLYMERIZATION; RESPIRATORY CHAIN; TRANSGENIC MOUSE; WILD TYPE;

ALCOHOL DRINKING; ANIMALS; BODY WEIGHT; CASPASE 3; CATALASE; CYTOCHROME P-450 CYP2E1; DEFEROXAMINE; DNA DAMAGE; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DOWN-REGULATION; ELECTRON TRANSPORT COMPLEX I; ETHANOL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIGH MOBILITY GROUP PROTEINS; IRON; IRON CHELATING AGENTS; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, LIVER; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PROTEIN CARBONYLATION; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSCRIPTION FACTORS; UP-REGULATION;

MUS; MUS MUSCULUS;

EID: 58949094505     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.11.004     Document Type: Article

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