Proteolysis of prion protein by cathepsin S generates a soluble β-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms

European Biophysics Journal

Volumn 38, Issue 2, 2009, Pages 209-218

  Polyakova, Oxana ^a   Dear, Denise ^b   Stern, Igor ^b   Martin, Stephen ^a   Hirst, Elizabeth ^a   Bawumia, Suleman ^a   Nash, Angus ^a   Dodson, Guy ^a   Bronstein, Igor ^a,c   Bayley, Peter M ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Circular dichroism; Pathogenicity; Proteolysis; Thioflavin T; Truncation mutants

Indexed keywords

ANIMALS; CATHEPSINS; CIRCULAR DICHROISM; HYDROLYSIS; NEUROTOXINS; PEPTIDE FRAGMENTS; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; SEQUENCE DELETION; SHEEP; THIAZOLES;

MUS; OVIS;

EID: 58849147421     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-008-0371-3     Document Type: Article

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