Mechanism of oxidative DNA damage in diabetes tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2′-deoxyguanosine- DNA glycosylase

Diabetes

Volumn 57, Issue 10, 2008, Pages 2626-2636

  Simone, Simona ^a,b   Gorin, Yves ^a   Velagapudi, Chakradhar ^a   Abboud, Hanna E ^a,c   Habib, Samy L ^a,c  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF BARI   (Italy)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; DNA GLYCOSYLTRANSFERASE; GLUCOSE; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TUBERIN; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE; OGG1 PROTEIN, RAT; ONCOPROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; EPITHELIUM CELL; GLUCOSE BLOOD LEVEL; INCUBATION TIME; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY CORTEX; KIDNEY PARENCHYMA; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; ANIMAL; CYTOLOGY; DIABETES MELLITUS; DRUG EFFECT; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION;

ACETYLCYSTEINE; ANIMALS; CELLS, CULTURED; DEOXYGUANOSINE; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; DNA DAMAGE; DNA GLYCOSYLASES; GLUCOSE; HYDROGEN PEROXIDE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; ONCOGENE PROTEIN V-AKT; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEINS;

EID: 58149340148     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1579     Document Type: Article

References (51)

1. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001
2. Lee HB, Yu MR, Yang Y, Jiang Z, Ha H: Reactive oxygen species-regulated signaling pathways in diabetic nephropathy. J Am, Soc Nephrol 14:S241- S245, 2003
3. Wolf G: New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology. Eur J Clin Invest 34:785-796, 2004
4. Brownlee M: The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54:1615-1625, 2005
5. Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622, 2002
6. Greenman IC, Gomez E, Moore CE, Herbert TP: Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic beta-cells. J Endocrinol 192:179-187, 2007
7. Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344, 2003
8. Evans MD, Dizdaroglu M, Cooke MS: Oxidative DNA damage and disease: induction, repair and significance. Mutat Res 567:1-61, 2004
9. Hutter E, Skovbro M, Lener B, Prats C, Rabol R, Dela F, Jansen-Durr P: Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6:245-256, 2007
10. Maiese K, Morhan SD, Chong ZZ: Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 4:63-71, 2007
11. Rachek LI, Musiyenko SI, LeDoux SP, Wilson GL: Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in L6 rat skeletal muscle cells. Endocrinology 148:293-299, 2007
12. Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y: Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis 11:345-347, 1990
13. Dandona P, Thusu K, Cook S: Oxidative damage to DNA in diabetes mellitus. Lancet 347:444-445, 1996
14. Leinonen J, Lehtimaki T, Toyokuni S: New biomarker evidence of oxida- tive DNA damage in patients with non-insulin-dependent diabetes mellitus. FEBS Lett 417:150-152, 1997
15. Hinokio Y, Suzuki S, Hirai M, Chiba M, Hirai A, Toyota T: Oxidative DNA damage in diabetes mellitus: its association with diabetic complications. Diabetologia 42:995-998, 1999
16. Nishikawa T, Sasahara T, Kiritoshi S: Evaluation of urinary 8-hy- droxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes. Diabetes Care 26:1507-1512, 2003
17. Smart DJ, Chipman JK, Hodges NJ: Activity of OGG1 variants in the repair of prooxidant-induced 8-oxo-2′-deoxyguanosine. DNA Repair (Amst) 5:1337-1345, 2006
18. Mitra S, Boldogh I, Izumi T, Hazra TK: Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ Mol Mutagen 38:180-190, 2001
19. de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA: Repair of 8-oxodeoxyguanosine lesions in mito- chondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1- defective mice. Cancer Res 14:5378-5381, 2001
20. Habib SL, Phan MN, Patel SK, Li D, Monks TJ, Lau SS: Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis 24:573-582, 2003
21. Habib SL, Riley DJ, Bhandari B, Mahimainathan L, Choudhury GG, Abboud HE: Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol 294:F281-F290, 2007
22. Plank TL, Yeung RS, Henske EP: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 58:4766 -4770, 1998
23. Van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 7:1053-1057, 1998
24. Hengstschlager M, Rodman DM, Miloloza A, Hengstschlager-Ottnad E, Rosner M, Kubista M: Tuberous sclerosis gene products in proliferation control. Mutat Res 488:233-239, 2001
25. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162, 2002
26. Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ: Phosphatidylinositol 3-ki- nase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277:35364-35370, 2002
27. Inoki K, Li Y, Zhu T, Wu J, Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657, 2002
28. Potter CJ, Pedraza LG, Xu T: Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4:658-665, 2002
29. Gorin Y, Block K, Hernandez J, Bhandari B, Wagner B, Barnes JL, Abboud HE: Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 280:39616-39626, 2005
30. GorinY, Kim NH, Feliers D, Bhandari B, Choudhury GG, Abboud HE: Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox- dependent pathway and independent of phosphoinositide 3-kinase. FASEB J 15:1909-1920, 2001
31. Kim NH, Rincon-Choles H, Bhandari B, Choudhury GG, Abboud HE, Gorin Y: Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol 291:F254, 2006
32. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, FujioY, Walsh K, Griendling KK: Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 274:22699-22704, 1999
33. Glynne PA: Primary culture of human proximal renal tubular epithelial cells. In Methods in Molecular Medicine: Septic Shock. Vol. 36. Evans TJ, Ed. Totowa, NJ, Humana Press, 1999, p. 197-205
34. Haverty TP, Kelly CJ, Hines WH, Amenta PS, Watanabe M, Harper RA, Kefalides NA, Neilson EG: Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol 107:1359-1368, 1988
35. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
36. Barnes J, Mitchell R, Kanalas J, Barnes VL: Differential expression of thrombospondin and cellular fibronectin during remodeling in proliferative glomerulonephritis. J Histochem Cytochem 47:533-544, 1999
37. Mariappan MM, Feliers D, Mummidi S, Choudhury GG, Kasinath BS: High glucose, high insulin, and their combination rapidly induce laminin-p1 synthesis by regulation of mRNA translation in renal epithelial cells. Diabetes 56:476-485, 2007
38. Konishi H, Matsuzaki H, Tanaka M, Takemura Y, Kuroda S, Ono Y, Kikkawa U: Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 410:493-498,1997
39. Venkatesan B, Mahimainathan L, Das F, Ghosh-Choudhury N, Choudhury GG: Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells. J Cell Physiol 211:457-467, 2007
40. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem J 336:241-246, 1998
41. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939-1945, 2000
42. Fioretto P, Mauer M, Brocco E, Velussi M, Frigato F, Muollo B, Sambataro M, Abaterusso C, Baggio B, Crepaldi G, Nosadini R: Patterns of renal injury in NIDDM patients with microalbuminuria. Diabetologia 39:1569-1576, 1996
43. +-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol 25:575-589, 2005
44. Sheu ML, Ho FM, Chao KF, Kuo ML, Liu SH: Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-κB activation and cyclooxygenase-2 expression in mesangial cells. Mol Pharmacol 66:187-196, 2004
45. Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ: Phosphatidylinositol 3-ki- nase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277:35364-35370, 2000
46. Aicher LD, Campbell JS, Yeung RS: Tuberin phosphorylation regulates its interaction with hamartin: two proteins involved in tuberous sclerosis. J Biol Chem 276:21017-21021, 2001
47. Thomas G, Bhat J, Wittman V, Thekkumkara TJ: Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury. Am J Physiol Renal Physiol. 291:F162-F175, 2006
48. Tsuruya K, Furuichi M, Tominaga Y, Shinozaki M, Tokumoto M, Yoshim- itsu T, Fukuda K, Kanai H, Hirakata H, Iida M, Nakabeppu Y: Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney, DNA Repair 2:211-229, 2003
49. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85-96, 2002
50. Kakimoto M, Inoguchi T, Sonta HY, Yu M, Imamura T, Etoh T, Hashimoto T, Nawata H: Accumulation of 8-hydroxy-2′ -deoxyguanosine and mito- chondrial DNA deletion in kidney of diabetic rats. Diabetes 51:1588-1595, 2002
51. Samikkannu T, Thomas JJ, Bhat GJ, Wittman V, Thekkumkara TJ: Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury. Am J Physiol Renal Physiol 291:F162-F175, 2006