Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2′-deoxyguanosine

DNA Repair

Volumn 5, Issue 11, 2006, Pages 1337-1345

  Smart, D J ^a   Chipman, J K ^a   Hodges, N J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

8 Oxodeoxyguanosine (8 oxodG); 8 Oxoguanine DNA glycosylase 1 (OGG1); Cancer; Oxidative stress; Polymorphism; Reactive oxygen species (ROS)

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 OXOGUANINE DNA GLYCOSYLASE 1; CYSTEINE RICH 8 OXOGUANINE DNA GLYCOSYLASE 1; ENZYME; GLYCINE RICH 8 OXOGUANINE DNA GLYCOSYLASE 1; ISOPROTEIN; SERINE RICH 8 OXOGUANINE DNA GLYCOSYLASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA DAMAGE; DNA STRAND BREAKAGE; EMBRYO; EXCISION REPAIR; FIBROBLAST CULTURE; FUNCTIONAL PROTEOMICS; GENETIC VARIABILITY; MOUSE; NONHUMAN; NULL CELL; OXIDATION KINETICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN VARIANT; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BROMATES; CELL LINE; CHROMATES; COMET ASSAY; DEOXYADENOSINES; DNA BREAKS; DNA GLYCOSYLASES; DNA REPAIR; GLUTATHIONE; HUMANS; LIGHT; MICE; MUTAGENS; OXIDANTS; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; PYRROLIDINES; QUINOLIZINES; REACTIVE OXYGEN SPECIES;

EID: 33750010979     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2006.06.001     Document Type: Article

References (54)

1. Klaunig J.E., and Kamendulis L.M. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 239-267
2. Kohen R., and Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 30 (2002) 620-650
3. Wiseman H., and Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 313 Pt. 1 (1996) 17-29
4. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362 (1993) 709-715
5. Wang D., Kreutzer D.A., and Essigmann J.M. Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat. Res. 400 (1998) 99-115
6. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat. Res. 387 (1997) 147-163
7. Helbock H.J., Beckman K.B., and Ames B.N. 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol. 300 (1999) 156-166
8. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., and Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J. Biol. Chem. 267 (1992) 166-172
9. Grollman A.P., and Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9 (1993) 246-249
10. Marnett L.J. Oxyradicals and DNA damage. Carcinogenesis 21 (2000) 361-370
11. Michaels M.L., and Miller J.H. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J. Bacteriol. 174 (1992) 6321-6325
12. Slupphaug G., Kavli B., and Krokan H.E. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat. Res. 531 (2003) 231-251
13. Boiteux S., and Radicella J.P. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch. Biochem. Biophys. 377 (2000) 1-8
14. Christmann M., Tomicic M.T., Roos W.P., and Kaina B. Mechanisms of human DNA repair: an update. Toxicology 193 (2003) 3-34
15. Wilson S.H., and Kunkel T.A. Passing the baton in base excision repair. Nat. Struct. Biol. 7 (2000) 176-178
16. Klungland A., Rosewell I., Hollenbach S., Larsen E., Daly G., Epe B., Seeberg E., Lindahl T., and Barnes D.E. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 13300-13305
17. Cabrera M., Nghiem Y., and Miller J.H. mutM, a second mutator locus in Escherichia coli that generates G.C → T.A transversions. J. Bacteriol. 170 (1988) 5405-5407
18. Thomas D., Scot A.D., Barbey R., Padula M., and Boiteux S. Inactivation of OGG1 increases the incidence of G.C → T.A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells. Mol. Gen. Genet. 254 (1997) 171-178
19. Sakumi K., Tominaga Y., Furuichi M., Xu P., Tsuzuki T., Sekiguchi M., and Nakabeppu Y. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 63 (2003) 902-905
20. Kunisada M., Sakumi K., Tominaga Y., Budiyanto A., Ueda M., Ichihashi M., Nakabeppu Y., and Nishigori C. 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res. 65 (2005) 6006-6010
21. Lu R., Nash H.M., and Verdine G.L. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr. Biol. (1997) 397-407
22. Hardie L.J., Briggs J.A., Davidson L.A., Allan J.M., King R.F., Williams G.I., and Wild C.P. The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer. Carcinogenesis 21 (2000) 167-172
23. Weiss J.M., Goode E.L., Ladiges W.C., and Ulrich C.M. Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature. Mol. Carcinogen. 42 (2005) 127-141
24. Ostling O., and Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 123 (1984) 291-298
25. Eastman A., and Barry M.A. The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis?. Cancer Invest. 10 (1992) 229-240
26. Speit G., and Hartmann A. The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). Mutagenesis 10 (1995) 555-559
27. Duthie S.J., Ma A., Ross M.A., and Collins A.R. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 56 (1996) 1291-1295
28. Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 26 (2004) 249-261
29. Will O., Gocke E., Eckert I., Schulz I., Pflaum M., Mahler H.C., and Epe B. Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022. Mutat. Res. 435 (1999) 89-101
30. Lee A., Hodges N.J., and Chipman J.K. Modified comet assay as a biomarker of sodium dichromate-induced oxidative DNA damage: optimization and reproducibility. Biomarkers 9 (2004) 103-115
31. Ballmaier D., and Epe B. Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells. Carcinogenesis 16 (1995) 335-342
32. Kasai H., Nishimura S., Kurokawa Y., and Hayashi Y. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 8 (1987) 1959-1961
33. Duez P., Dehon G., Kumps A., and Dubois J. Statistics of the Comet assay: a key to discriminate between genotoxic effects. Mutagenesis 18 (2003) 159-166
34. Osterod M., Hollenbach S., Hengstler J.G., Barnes D.E., Lindahl T., and Epe B. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis 22 (2001) 1459-1463
35. Le Page F., Klungland A., Barnes D.E., Sarasin A., and Boiteux S. Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in non-transcribed sequences but not in transcribed sequences. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 8397-8402
36. Arai T., Kelly V.P., Minowa O., Noda T., and Nishimura S. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis 23 (2002) 2005-2010
37. Lee A.J., Hodges N.J., and Chipman J.K. Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2′-deoxyguanosine DNA glycosylase 1. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 497-505
38. Dantzer F., Luna L., Bjoras M., and Seeberg E. Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo. Nucleic Acids Res. 30 (2002) 2349-2357
39. Hu J., Imam S.Z., Hashiguchi K., de Souza-Pinto N.C., and Bohr V.A. Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function. Nucleic Acids Res. 33 (2005) 3271-3282
40. Luna L., Rolseth V., Hildrestrand G.A., Otterlei M., Dantzer F., Bjoras M., and Seeberg E. Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant. Nucleic Acids Res. 33 (2005) 1813-1824
41. Giustarini D., Rossi R., Milzani A., Colombo R., and Dalle-Donne I. S-glutathionylation: from redox regulation of protein functions to human diseases. J. Cell Mol. Med. 8 (2004) 201-212
42. Davies M.J. Singlet oxygen-mediated damage to proteins and its consequences. Biochem. Biophys. Res. Commun. 305 (2003) 761-770
43. Hill J.W., and Evans M.K. Dimerisation and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucl Acid Res. 34 (2006) 1620-1634
44. Finkel T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15 (2003) 247-254
45. Jaiswal M., LaRusso N.F., Nishioka N., Nakabeppu Y., and Gores G.J. Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. Cancer Res. 61 (2001) 6388-6393
46. Kohno T., Shinmura K., Tosaka M., Tani M., Kim S.R., Sugimura H., Nohmi T., Kasai H., and Yokota J. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 16 (1998) 3219-3225
47. Yamane A., Kohno T., Ito K., Sunaga N., Aoki K., Yoshimura K., Murakami H., Nojima Y., and Yokota J. Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cells in vivo. Carcinogenesis 25 (2004) 1689-1694
48. Chen L., Elahi A., Pow-Sang J., Lazarus P., and Park J. Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer. J. Urol. 170 (2003) 2471-2474
49. Paz-Elizur T., Krupsky M., Blumenstein S., Elinger D., Schechtman E., and Livneh Z. DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95 (2003) 1312-1319
50. Kim S.R., Matsui K., Yamada M., Kohno T., Kasai H., Yokota J., and Nohmi T. Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase. Mutat. Res. 554 (2004) 365-374
51. Janssen K., Schlink K., Gotte W., Hippler B., Kaina B., and Oesch F. DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326. Mutat. Res. 486 (2001) 207-216
52. Dherin C., Radicella J.P., Dizdaroglu M., and Boiteux S. Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations. Nucleic Acids Res. 27 (1999) 4001-4007
53. Fortini P., Pascucci B., Parlanti E., D'Errico M., Simonelli V., and Dogliotti E. The base excision repair: mechanisms and its relevance for cancer susceptibility. Biochimie 85 (2003) 1053-1071
54. Nohmi T., Kim S.R., and Yamada M. Modulation of oxidative mutagenesis and carcinogenesis by polymorphic forms of human DNA repair enzymes. Mutat. Res. 591 (2005) 60-73