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Volumn 181, Issue 7, 2008, Pages 5062-5070

STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

CD45RB ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ISOPROTEIN; STAT4 ALPHA PROTEIN; STAT4 BETA PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; LYMPHOCYTE ANTIGEN RECEPTOR; STAT4 PROTEIN, MOUSE;

EID: 58149296553     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.7.5062     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 0034661356 scopus 로고    scopus 로고
    • Lineage commitment in the immune system: The T helper lymphocyte grows up
    • Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711.
    • (2000) Genes Dev. , vol.14 , pp. 1693-1711
    • Glimcher, L.H.1    Murphy, K.M.2
  • 2
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 3
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7    Yu, N.8    Wang, J.9    Singh, K.10
  • 4
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • DOI 10.1074/jbc.M207577200
    • Aggarwal, S., N. Ghilardi, M. H. Xie, F. J. de Sauvage, and A. L. Gurney. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278: 1910-1914. (Pubitemid 36801431)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.-H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 5
    • 8944226108 scopus 로고    scopus 로고
    • Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
    • Micallef, M. J., T. Ohtsuki, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, M. Fujii, M. Ikeda, et al. 1996. Interferon-γ- inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol. 26: 1647-1651.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1647-1651
    • Micallef, M.J.1    Ohtsuki, T.2    Kohno, K.3    Tanabe, F.4    Ushio, S.5    Namba, M.6    Tanimoto, T.7    Torigoe, K.8    Fujii, M.9    Ikeda, M.10
  • 6
    • 27144526101 scopus 로고    scopus 로고
    • Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression
    • Martins, G. A., A. S. Hutchins, and S. L. Reiner. 2005. Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. J. Immunol. 175: 5981-5985.
    • (2005) J. Immunol. , vol.175 , pp. 5981-5985
    • Martins, G.A.1    Hutchins, A.S.2    Reiner, S.L.3
  • 7
    • 0037108385 scopus 로고    scopus 로고
    • Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12Rβ2 chain expression and signaling
    • Nishikomori, R., T. Usui, C. Y. Wu, A. Morinobu, J. J. O'Shea, and W. Strober. 2002. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R β 2 chain expression and signaling. J. Immunol. 169: 4388-4398. (Pubitemid 35178213)
    • (2002) Journal of Immunology , vol.169 , Issue.8 , pp. 4388-4398
    • Nishikomori, R.1    Usui, T.2    Wu, C.-Y.3    Morinobu, A.4    O'Shea, J.J.5    Strober, W.6
  • 9
    • 0035070195 scopus 로고    scopus 로고
    • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
    • Grogan, J. L., M. Mohrs, B. Harmon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14: 205-215.
    • (2001) Immunity , vol.14 , pp. 205-215
    • Grogan, J.L.1    Mohrs, M.2    Harmon, B.3    Lacy, D.A.4    Sedat, J.W.5    Locksley, R.M.6
  • 11
    • 0033775779 scopus 로고    scopus 로고
    • Interleukin-12 differentially regulates expression of IFN-γ and interleukin-2 in human T lymphoblasts
    • DOI 10.1089/10799900050163271
    • Dickensheets, H. L., S. L. Freeman, and R. P. Donnelly. 2000. Interleukin-12 differentially regulates expression of IFN-γ and interleukin-2 in human T lymphoblasts. J. Interferon Cytokine Res. 20: 897-905. (Pubitemid 30776691)
    • (2000) Journal of Interferon and Cytokine Research , vol.20 , Issue.10 , pp. 897-905
    • Dickensheets, H.L.1    Freeman, S.L.2    Donnelly, R.P.3
  • 12
    • 33947257812 scopus 로고    scopus 로고
    • Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
    • Hildner, K. M., P. Schirmacher, I. Atreya, M. Dittmayer, B. Bartsch, P. R. Galle, S. Wirtz, and M. F. Neurath. 2007. Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis. J. Immunol. 178: 3427-3436.
    • (2007) J. Immunol. , vol.178 , pp. 3427-3436
    • Hildner, K.M.1    Schirmacher, P.2    Atreya, I.3    Dittmayer, M.4    Bartsch, B.5    Galle, P.R.6    Wirtz, S.7    Neurath, M.F.8
  • 13
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
    • Simpson, S. J., S. Shah, M. Comiskey, Y. P. de Jong, B. Wang, E. Mizoguchi, A. K. Bhan, and C. Terhorst. 1998. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J. Exp. Med. 187: 1225-1234.
    • (1998) J. Exp. Med. , vol.187 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3    De Jong, Y.P.4    Wang, B.5    Mizoguchi, E.6    Bhan, A.K.7    Terhorst, C.8
  • 14
    • 18244392419 scopus 로고    scopus 로고
    • STAT4: A critical regulator of inflammation in vivo
    • Kaplan, M. H. 2005. STAT4: a critical regulator of inflammation in vivo. Immunol. Res. 31: 231-242.
    • (2005) Immunol. Res. , vol.31 , pp. 231-242
    • Kaplan, M.H.1
  • 17
    • 37349050665 scopus 로고    scopus 로고
    • Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients
    • Pang, Y. H., C. Q. Zheng, X. Z. Yang, and W. J. Zhang. 2007. Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients. Cell. Immunol. 248: 115-120.
    • (2007) Cell. Immunol. , vol.248 , pp. 115-120
    • Pang, Y.H.1    Zheng, C.Q.2    Yang, X.Z.3    Zhang, W.J.4
  • 19
    • 3142588819 scopus 로고    scopus 로고
    • Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease - A possible target for infliximab treatment
    • DOI 10.1097/01.meg.0000108344.41221.8b
    • Agnholt, J., J. Kelsen, B. Brandsborg, N. O. Jakobsen, and J. F. Dahlerup. 2004. Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease-a possible target for infliximab treatment. Eur. J. Gastroenterol. Hepatol. 16: 649-655. (Pubitemid 38901632)
    • (2004) European Journal of Gastroenterology and Hepatology , vol.16 , Issue.7 , pp. 649-655
    • Agnholt, J.1    Kelsen, J.2    Brandsborg, B.3    Jakobsen, N.O.4    Dahlerup, J.F.5
  • 26
    • 0042466572 scopus 로고    scopus 로고
    • Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL-12 responses
    • DOI 10.1093/emboj/cdg393
    • Hoey, T., S. Zhang, N. Schmidt, Q. Yu, S. Ramchandani, X. Xu, L. K. Naeger, Y. L. Sun, and M. H. Kaplan. 2003. Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL-12 responses. EMBO J. 22: 4237-4248. (Pubitemid 37021751)
    • (2003) EMBO Journal , vol.22 , Issue.16 , pp. 4237-4248
    • Hoey, T.1    Zhang, S.2    Schmidt, N.3    Yu, Q.4    Ramchandani, S.5    Xu, X.6    Naeger, L.K.7    Sun, Y.-L.8    Kaplan, M.H.9
  • 27
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 28
    • 42449098038 scopus 로고    scopus 로고
    • Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease
    • DOI 10.1002/ibd.20344
    • Eri, R., K. N. Kodumudi, D. J. Summerlin, and M. Srinivasan. 2008. Suppression of colon inflammation by CD80 blockade: evaluation in two murine models of inflammatory bowel disease. Inflamm. Bowel Dis. 14: 458-470. (Pubitemid 351571825)
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.4 , pp. 458-470
    • Eri, R.1    Kodumudi, K.N.2    Summerlin, D.J.3    Srinivasan, M.4
  • 30
    • 49149126701 scopus 로고    scopus 로고
    • IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6
    • Sehra, S., H. A. Bruns, A. N. Ahyi, E. T. Nguyen, N. W. Schmidt, E. G. Michels, G. U. von Bulow, and M. H. Kaplan. 2008. IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J. Immunol. 180: 3551-3559.
    • (2008) J. Immunol. , vol.180 , pp. 3551-3559
    • Sehra, S.1    Bruns, H.A.2    Ahyi, A.N.3    Nguyen, E.T.4    Schmidt, N.W.5    Michels, E.G.6    Von Bulow, G.U.7    Kaplan, M.H.8
  • 32
    • 0030909889 scopus 로고    scopus 로고
    • The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B
    • Souza, M. H., A. A. Melo-Filho, M. F. Rocha, D. M. Lyerly, F. Q. Cunha, A. A. Lima, and R. A. Ribeiro. 1997. The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B. Immunology 91: 281-288.
    • (1997) Immunology , vol.91 , pp. 281-288
    • Souza, M.H.1    Melo-Filho, A.A.2    Rocha, M.F.3    Lyerly, D.M.4    Cunha, F.Q.5    Lima, A.A.6    Ribeiro, R.A.7
  • 33
    • 0030209985 scopus 로고    scopus 로고
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157: 1261-1270.
    • (1996) J. Immunol. , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    De La Motte, C.5    Strong, S.A.6    Fiocchi, C.7    Strober, W.8
  • 34
    • 34548354856 scopus 로고    scopus 로고
    • Inflammatory bowel disease in children: An overview for pediatric healthcare providers
    • quiz 283-1274
    • Merchant, A. 2007. Inflammatory bowel disease in children: an overview for pediatric healthcare providers. Gastroenterol. Nurs. 30: 278-282; quiz 283-1274
    • (2007) Gastroenterol. Nurs. , vol.30 , pp. 278-282
    • Merchant, A.1
  • 36
    • 0028910777 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor-α promoter region
    • Rhoades, K. L., S. Cai, S. H. Golub, and J. S. Economou. 1995. Granulocyte-macrophage colony-stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor-α promoter region. Cell. Immunol. 161: 125-131.
    • (1995) Cell. Immunol. , vol.161 , pp. 125-131
    • Rhoades, K.L.1    Cai, S.2    Golub, S.H.3    Economou, J.S.4
  • 37
  • 38
    • 0028972504 scopus 로고
    • Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper cell subsets
    • Bach, E. A., S. J. Szabo, A. S. Dighe, A. Ashkenazi, M. Aguet, K. M. Murphy, and R. D. Schreiber. 1995. Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper cell subsets. Science 270: 1215-1218.
    • (1995) Science , vol.270 , pp. 1215-1218
    • Bach, E.A.1    Szabo, S.J.2    Dighe, A.S.3    Ashkenazi, A.4    Aguet, M.5    Murphy, K.M.6    Schreiber, R.D.7
  • 40
    • 0029796380 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells
    • Chakraborty, A., S. M. White, T. S. Schaefer, E. D. Ball, K. F. Dyer, and D. J. Tweardy. 1996. Granulocyte colony-stimulating factor activation of Stat3 α and Stat3 β in immature normal and leukemic human myeloid cells. Blood 88: 2442-2449. (Pubitemid 26327492)
    • (1996) Blood , vol.88 , Issue.7 , pp. 2442-2449
    • Chakraborty, A.1    White, S.M.2    Schaefer, T.S.3    Ball, E.D.4    Dyer, K.F.5    Tweardy, D.J.6
  • 41
    • 0031825333 scopus 로고    scopus 로고
    • Stat3 and G-CSF-induced myeloid differentiation
    • Chakraborty, A., and D. J. Tweardy. 1998. Stat3 and G-CSF-induced myeloid differentiation. Leuk. Lymphoma 30: 433-442.
    • (1998) Leuk. Lymphoma , vol.30 , pp. 433-442
    • Chakraborty, A.1    Tweardy, D.J.2
  • 42
    • 23044498580 scopus 로고    scopus 로고
    • Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma
    • Robertson, M. J., H. C. Chang, D. Pelloso, and M. H. Kaplan. 2005. Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood 106: 963-970.
    • (2005) Blood , vol.106 , pp. 963-970
    • Robertson, M.J.1    Chang, H.C.2    Pelloso, D.3    Kaplan, M.H.4
  • 44
    • 34547458187 scopus 로고    scopus 로고
    • Polymorphisms of STAT-6, STAT-4 and IFN-γ genes and the risk of asthma in Chinese population
    • DOI 10.1016/j.rmed.2007.04.006, PII S0954611107001473
    • Li, Y., B. Wu, H. Xiong, C. Zhu, and L. Zhang. 2007. Polymorphisms of STAT-6, STAT-4 and IFN-γ genes and the risk of asthma in Chinese population. Respir. Med. 101: 1977-1981. (Pubitemid 47163531)
    • (2007) Respiratory Medicine , vol.101 , Issue.9 , pp. 1977-1981
    • Li, Y.1    Wu, B.2    Xiong, H.3    Zhu, C.4    Zhang, L.5
  • 46
    • 35348917269 scopus 로고    scopus 로고
    • Association of STAT4 with rheumatoid arthritis in the Korean population
    • DOI 10.2119/2007-00072.Lee
    • Lee, H. S., E. F. Remmers, J. M. Le, D. L. Kastner, S. C. Bae, and P. K. Gregersen. 2007. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol. Med. 13: 455-460. (Pubitemid 47585739)
    • (2007) Molecular Medicine , vol.13 , Issue.9-10 , pp. 455-460
    • Lee, H.-S.1    Remmers, E.F.2    Le, J.M.3    Kastner, D.L.4    Bae, S.-C.5    Gregersen, P.K.6


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