메뉴 건너뛰기




Volumn 106, Issue 3, 2005, Pages 963-970

Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 18; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STAT4 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

EID: 23044498580     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-01-0201     Document Type: Article
Times cited : (21)

References (60)
  • 1
    • 0029112299 scopus 로고
    • Coherent view of non-Hodgkin's lymphoma
    • Aisenberg AC. Coherent view of non-Hodgkin's lymphoma. J Clin Oncol. 1995;13;2656-2675.
    • (1995) J Clin Oncol , vol.13 , pp. 2656-2675
    • Aisenberg, A.C.1
  • 3
    • 0028790440 scopus 로고
    • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma
    • Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med. 1995;333:1540-1545.
    • (1995) N Engl J Med , vol.333 , pp. 1540-1545
    • Philip, T.1    Guglielmi, C.2    Hagenbeek, A.3
  • 4
    • 0742323747 scopus 로고    scopus 로고
    • Autologous transplantation for diffuse aggressive non-Hodgkin lymphoma in first relapse or second remission
    • Vose JM, Rizzo DJ, Tao-Wu J, et al. Autologous transplantation for diffuse aggressive non-Hodgkin lymphoma in first relapse or second remission. Biol Blood Marrow Transplant. 2004;10: 116-127.
    • (2004) Biol Blood Marrow Transplant , vol.10 , pp. 116-127
    • Vose, J.M.1    Rizzo, D.J.2    Tao-Wu, J.3
  • 5
    • 0030942265 scopus 로고    scopus 로고
    • Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin's disease
    • Yuen AR, Rosenberg SA, Hoppe RT, Halpern JD, Horning SJ. Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin's disease. Blood. 1997;89:814-822.
    • (1997) Blood , vol.89 , pp. 814-822
    • Yuen, A.R.1    Rosenberg, S.A.2    Hoppe, R.T.3    Halpern, J.D.4    Horning, S.J.5
  • 6
    • 0037080278 scopus 로고    scopus 로고
    • Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin's disease in relapse or failure after initial chemotherapy: Results of the Groupe d'Etudes des Lymphomes de l'Adulte H89 trial
    • Ferme C, Mounier N, Divine M, et al. Intensive salvage therapy with high-dose chemotherapy for patients with advanced Hodgkin's disease in relapse or failure after initial chemotherapy: results of the Groupe d'Etudes des Lymphomes de l'Adulte H89 trial. J Clin Oncol. 2002;20:467-475.
    • (2002) J Clin Oncol , vol.20 , pp. 467-475
    • Ferme, C.1    Mounier, N.2    Divine, M.3
  • 8
    • 0029099188 scopus 로고
    • Immunotherapy with interleukin 2 with or without lymphokine-activated killer cells after autologous bone marrow transplantation for malignant lymphoma: A feasibility trial
    • Benyunes MC, Higuchi CM, York A, et al. Immunotherapy with interleukin 2 with or without lymphokine-activated killer cells after autologous bone marrow transplantation for malignant lymphoma: a feasibility trial. Bone Marrow Transplant. 1995;16:283-288.
    • (1995) Bone Marrow Transplant , vol.16 , pp. 283-288
    • Benyunes, M.C.1    Higuchi, C.M.2    York, A.3
  • 9
    • 0034774902 scopus 로고    scopus 로고
    • Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma
    • Davis TA, Hsu FJ, Caspar CB, et al. Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. Biol Blood Marrow Transplant. 20017:517-522.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 517-522
    • Davis, T.A.1    Hsu, F.J.2    Caspar, C.B.3
  • 10
    • 9144266912 scopus 로고    scopus 로고
    • Rituximab as adjuvant to high-dose therapy and autologous hematopoietic stem cell transplantation for aggressive non-Hodgkin lymphoma
    • Horwitz SM, Negrin RS, Blume KG, et al. Rituximab as adjuvant to high-dose therapy and autologous hematopoietic stem cell transplantation for aggressive non-Hodgkin lymphoma. Blood. 2004;103:777-783.
    • (2004) Blood , vol.103 , pp. 777-783
    • Horwitz, S.M.1    Negrin, R.S.2    Blume, K.G.3
  • 11
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 1995;13: 251-276.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 12
    • 0027239503 scopus 로고
    • Antitumor and antimetastatic activity of interleukin 12 against murine tumors
    • Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med. 1993;178: 1223-1230.
    • (1993) J Exp Med , vol.178 , pp. 1223-1230
    • Brunda, M.J.1    Luistro, L.2    Warrier, R.R.3
  • 13
    • 0027963161 scopus 로고
    • Recombinant IL-12 administration induces tumor regression in association with IFN-γ production
    • Nastala CL, Edington HD, McKinney TG, et al. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J Immunol. 1994;153:1697-1706.
    • (1994) J Immunol , vol.153 , pp. 1697-1706
    • Nastala, C.L.1    Edington, H.D.2    McKinney, T.G.3
  • 14
    • 0029039610 scopus 로고
    • Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
    • Zou J-P, Yamamoto N, Fujii T, et al. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells. Int Immunol. 1995;7:1135-1145.
    • (1995) Int Immunol , vol.7 , pp. 1135-1145
    • Zou, J.-P.1    Yamamoto, N.2    Fujii, T.3
  • 15
    • 0029090220 scopus 로고
    • Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes
    • Mu J, Zou J-P, Yamamoto N, et al. Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res. 1995;55: 4404-4408.
    • (1995) Cancer Res , vol.55 , pp. 4404-4408
    • Mu, J.1    Zou, J.-P.2    Yamamoto, N.3
  • 17
    • 0037220470 scopus 로고    scopus 로고
    • + T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-γ
    • + T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-γ. J Immunol. 2003;170:400-412.
    • (2003) J Immunol , vol.170 , pp. 400-412
    • Hess, S.D.1    Egilmez, N.K.2    Bailey, N.3
  • 18
    • 0031919849 scopus 로고    scopus 로고
    • JAKS and STATS: Biological implications
    • Leonard WJ, O'Shea JJ. JAKS and STATS: biological implications. Annu Rev Immunol. 1998;16: 293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 19
    • 0031943618 scopus 로고    scopus 로고
    • The interleukin-12/interleukin-12 receptor system: Role in normal and pathologic immune responses
    • Gately MK, Renzetti LM, Magram J, et al. The interleukin-12/interleukin- 12 receptor system: role in normal and pathologic immune responses. Annu Rev Immunol. 1998;16:495-521.
    • (1998) Annu Rev Immunol , vol.16 , pp. 495-521
    • Gately, M.K.1    Renzetti, L.M.2    Magram, J.3
  • 20
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun Y-L, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996;382:174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4
  • 21
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    • Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996;382:171-174.
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1    Van Deursen, J.M.2    Yamamoto, K.3
  • 22
    • 0036847429 scopus 로고    scopus 로고
    • Interleukin-12 immunotherapy after autologous stem cell transplantation for hematologic malignancies
    • Robertson MJ, Pelloso D, Abonour R, et al. Interleukin-12 immunotherapy after autologous stem cell transplantation for hematologic malignancies. Clin Cancer Res. 2002;8:3383-3393.
    • (2002) Clin Cancer Res , vol.8 , pp. 3383-3393
    • Robertson, M.J.1    Pelloso, D.2    Abonour, R.3
  • 23
    • 1642303259 scopus 로고    scopus 로고
    • Immunological consequences of interleukin 12 administration after autologous stem cell transplantation
    • Pelloso D, Cyran K, Timmons L, Williams BT, Robertson MJ. Immunological consequences of interleukin 12 administration after autologous stem cell transplantation. Clin Cancer Res. 2004; 10:1935-1942.
    • (2004) Clin Cancer Res , vol.10 , pp. 1935-1942
    • Pelloso, D.1    Cyran, K.2    Timmons, L.3    Williams, B.T.4    Robertson, M.J.5
  • 24
    • 4644250381 scopus 로고    scopus 로고
    • + cell doses in stem cell products is associated with inferior progression-free survival after autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma
    • + cell doses in stem cell products is associated with inferior progression-free survival after autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma [abstract]. Blood. 2003;102:987a.
    • (2003) Blood , vol.102
    • Robertson, M.1    Abonour, R.2    Hromas, R.3    Nelson, R.4    Fineberg, N.5    Cornetta, K.6
  • 25
    • 0025196196 scopus 로고
    • Human natural killer cell adhesion molecules: Differential expression after activation and participation in cytoiysis
    • Robertson MJ, Caligiuri MA, Manley TJ, Levine H, Ritz J. Human natural killer cell adhesion molecules: differential expression after activation and participation in cytoiysis. J Immunol. 1990;145: 3194-3201.
    • (1990) J Immunol , vol.145 , pp. 3194-3201
    • Robertson, M.J.1    Caligiuri, M.A.2    Manley, T.J.3    Levine, H.4    Ritz, J.5
  • 27
    • 0027364345 scopus 로고
    • Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation, and allogeneic bone marrow transplantation
    • Roberts MM, To LB, Gillis D, et al. Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation, and allogeneic bone marrow transplantation. Bone Marrow Transplant. 1993;12: 469-475.
    • (1993) Bone Marrow Transplant , vol.12 , pp. 469-475
    • Roberts, M.M.1    To, L.B.2    Gillis, D.3
  • 28
    • 0031035896 scopus 로고    scopus 로고
    • Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation
    • Koehne G, Zeller W, Stockschlaeder M, Zander AR. Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1997;19:149-156.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 149-156
    • Koehne, G.1    Zeller, W.2    Stockschlaeder, M.3    Zander, A.R.4
  • 29
    • 0032170052 scopus 로고    scopus 로고
    • Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation
    • Guillaume T, Rubinstein DB, Symann M. Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation. Blood. 1998;92:1471-1490.
    • (1998) Blood , vol.92 , pp. 1471-1490
    • Guillaume, T.1    Rubinstein, D.B.2    Symann, M.3
  • 30
    • 1642321982 scopus 로고    scopus 로고
    • IL-2, regulatory T cells, and tolerance
    • Nelson BH. IL-2, regulatory T cells, and tolerance. J Immunol. 2004;172:3983-3988.
    • (2004) J Immunol , vol.172 , pp. 3983-3988
    • Nelson, B.H.1
  • 31
    • 0035525739 scopus 로고    scopus 로고
    • + cells: A naturally occurring population of regulatory T cells
    • + cells: a naturally occurring population of regulatory T cells. Blood. 2001;98:2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 33
    • 0344153890 scopus 로고    scopus 로고
    • + T cells with IFN-γ-dependent anti-angiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination
    • + T cells with IFN-γ-dependent anti-angiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. J Immunol. 2003;171:5931-5939.
    • (2003) J Immunol , vol.171 , pp. 5931-5939
    • Casares, N.1    Arribillaga, L.2    Sarobe, P.3
  • 34
    • 0031777526 scopus 로고    scopus 로고
    • Regulation of T helper cell differentiation by STAT molecules
    • Kaplan MH, Grusby MJ. Regulation of T helper cell differentiation by STAT molecules. J Leukoc Biol. 1998;64:2-5.
    • (1998) J Leukoc Biol , vol.64 , pp. 2-5
    • Kaplan, M.H.1    Grusby, M.J.2
  • 35
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383: 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 36
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 1995;2:665-675.
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 37
    • 0031963014 scopus 로고    scopus 로고
    • Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    • Bonecchi R, Bianchi G, Bordignon PP, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998;187:129-134.
    • (1998) J Exp Med , vol.187 , pp. 129-134
    • Bonecchi, R.1    Bianchi, G.2    Bordignon, P.P.3
  • 38
    • 0032536869 scopus 로고    scopus 로고
    • Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
    • Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 1998;187:875-883.
    • (1998) J Exp Med , vol.187 , pp. 875-883
    • Sallusto, F.1    Lenig, D.2    Mackay, C.R.3    Lanzavecchia, A.4
  • 39
    • 0030769920 scopus 로고    scopus 로고
    • Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
    • Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 1997;277:2005-2007.
    • (1997) Science , vol.277 , pp. 2005-2007
    • Sallusto, F.1    Mackay, C.R.2    Lanzavecchia, A.3
  • 40
    • 0034530075 scopus 로고    scopus 로고
    • Lack of correlation between chemokine receptor and Th1/TH2 cytokine expression by individual memory T cells
    • Nanki T, Lipsky PE. Lack of correlation between chemokine receptor and Th1/TH2 cytokine expression by individual memory T cells. Int Immunol. 2000;12:1659-1667.
    • (2000) Int Immunol , vol.12 , pp. 1659-1667
    • Nanki, T.1    Lipsky, P.E.2
  • 41
    • 0034657259 scopus 로고    scopus 로고
    • Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4
    • Wang KS, Frank DA1 Ritz J. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood. 2000;95:3183-3190.
    • (2000) Blood , vol.95 , pp. 3183-3190
    • Wang, K.S.1    Frank, D.A.2    Ritz, J.3
  • 42
    • 0035877980 scopus 로고    scopus 로고
    • Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation
    • Wang KS, Zorn E, Ritz J. Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation. Blood. 2001;97:3860-3866.
    • (2001) Blood , vol.97 , pp. 3860-3866
    • Wang, K.S.1    Zorn, E.2    Ritz, J.3
  • 43
    • 0034284088 scopus 로고    scopus 로고
    • Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
    • Visconti R, Gadina M, Chiariello M, et al. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood. 2000;96:1844-1852.
    • (2000) Blood , vol.96 , pp. 1844-1852
    • Visconti, R.1    Gadina, M.2    Chiariello, M.3
  • 44
    • 0034254177 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
    • Zhang S, Kaplan MH. The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression. J Immunol. 2000;165:1375-1380.
    • (2000) J Immunol , vol.165 , pp. 1375-1380
    • Zhang, S.1    Kaplan, M.H.2
  • 45
    • 0035261399 scopus 로고    scopus 로고
    • IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
    • Yang J, Zhu H, Murphy TL, Ouyang W, Murphy KM. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat Immunol. 2001;2:157-164.
    • (2001) Nat Immunol , vol.2 , pp. 157-164
    • Yang, J.1    Zhu, H.2    Murphy, T.L.3    Ouyang, W.4    Murphy, K.M.5
  • 46
    • 0029990630 scopus 로고    scopus 로고
    • Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12
    • Yu W-G, Yamamoto N, Takenaka H, et al. Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12. Int Immunol. 1996;8: 855-865,
    • (1996) Int Immunol , vol.8 , pp. 855-865
    • Yu, W.-G.1    Yamamoto, N.2    Takenaka, H.3
  • 47
    • 0030709464 scopus 로고    scopus 로고
    • Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice
    • Yang Y-G, Sergio JJ, Pearson DA, Szot GL, Shimizu A, Sykes M. Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice. Blood. 1997;90:4651-4660.
    • (1997) Blood , vol.90 , pp. 4651-4660
    • Yang, Y.-G.1    Sergio, J.J.2    Pearson, D.A.3    Szot, G.L.4    Shimizu, A.5    Sykes, M.6
  • 48
    • 0035339389 scopus 로고    scopus 로고
    • Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection
    • Soares MM, Mehta V, Finn OJ. Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J Immunol. 2001;166:6555-6563.
    • (2001) J Immunol , vol.166 , pp. 6555-6563
    • Soares, M.M.1    Mehta, V.2    Finn, O.J.3
  • 49
    • 0035877073 scopus 로고    scopus 로고
    • Immunotherapy of melanoma: A dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy
    • Winter H, Hu H-M, McClain K, Urba WJ, Fox BA. Immunotherapy of melanoma: a dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy. J Immunol. 2001;166:7370-7380.
    • (2001) J Immunol , vol.166 , pp. 7370-7380
    • Winter, H.1    Hu, H.-M.2    McClain, K.3    Urba, W.J.4    Fox, B.A.5
  • 50
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000;6:443-446.
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 52
    • 11144244014 scopus 로고    scopus 로고
    • Stabilization of IFN-γ mRNA by MARK p38 in IL-12-and IL-18-stimulated human NK cells
    • Mavropoulos A, Sully G, Cope AP, Clark A. Stabilization of IFN-γ mRNA by MARK p38 in IL-12-and IL-18-stimulated human NK cells. Blood. 2004;105:282-288.
    • (2004) Blood , vol.105 , pp. 282-288
    • Mavropoulos, A.1    Sully, G.2    Cope, A.P.3    Clark, A.4
  • 53
    • 0032519453 scopus 로고    scopus 로고
    • Participation of the CD94 receptor complex in costimulation of human natural killer cells
    • Voss SD, Daley J, Ritz J, Robertson MJ. Participation of the CD94 receptor complex in costimulation of human natural killer cells. J Immunol. 1998;160:1618-1626.
    • (1998) J Immunol , vol.160 , pp. 1618-1626
    • Voss, S.D.1    Daley, J.2    Ritz, J.3    Robertson, M.J.4
  • 55
    • 0034671942 scopus 로고    scopus 로고
    • Stat4 regulates multiple components of IFN-γ-inducing signaling pathways
    • Lawless VA, Zhang S, Ozes ON, et al. Stat4 regulates multiple components of IFN-γ-inducing signaling pathways. J Immunol. 2000;165:6803-6808.
    • (2000) J Immunol , vol.165 , pp. 6803-6808
    • Lawless, V.A.1    Zhang, S.2    Ozes, O.N.3
  • 56
    • 0026512503 scopus 로고
    • Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation
    • Soiffer RJ, Murray C, Cochran K, et al. Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation. Blood. 1992;79:517-526.
    • (1992) Blood , vol.79 , pp. 517-526
    • Soiffer, R.J.1    Murray, C.2    Cochran, K.3
  • 57
    • 0031113474 scopus 로고    scopus 로고
    • Low dose subcutaneous interleukin-2 after autologous transplantation generates sustained in vivo natural killer cell activity
    • Miller JS, Tessmer-Tuck J, Pierson BA, et al. Low dose subcutaneous interleukin-2 after autologous transplantation generates sustained in vivo natural killer cell activity. Biol Blood Marrow Transplant. 1997;3:34-44.
    • (1997) Biol Blood Marrow Transplant , vol.3 , pp. 34-44
    • Miller, J.S.1    Tessmer-Tuck, J.2    Pierson, B.A.3
  • 58
    • 0038690512 scopus 로고    scopus 로고
    • Phase I trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell cancer
    • Gollob JA, Veenstra KG, Parker RA. et al. Phase I trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell cancer. J Clin Oncol. 2003;21:2564-2573.
    • (2003) J Clin Oncol , vol.21 , pp. 2564-2573
    • Gollob, J.A.1    Veenstra, K.G.2    Parker, R.A.3
  • 59
    • 1642360260 scopus 로고    scopus 로고
    • A phase I dose escalation study to assess safety and pharmacokinetics of recombinant human IL-18 (rhIL-18) administered as five daily intravenous infusions in adult patients with solid tumors
    • Robertson MJ, Mier J, Weisenbach J, et al. A phase I dose escalation study to assess safety and pharmacokinetics of recombinant human IL-18 (rhIL-18) administered as five daily intravenous infusions in adult patients with solid tumors [abstract 713]. Proc Am Soc Clin Oncol. 2003;22: 178.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 178
    • Robertson, M.J.1    Mier, J.2    Weisenbach, J.3
  • 60
    • 33544473741 scopus 로고    scopus 로고
    • Tolerability and anti-tumor activity of recombinant human IL-18 administered as five daily intravenous infusions in patients with solid tumors
    • Robertson MJ, Mier J, Logan T, et al. Tolerability and anti-tumor activity of recombinant human IL-18 administered as five daily intravenous infusions in patients with solid tumors [abstract 2553]. J Clin Oncol. 2004;22:176s.
    • (2004) J Clin Oncol , vol.22
    • Robertson, M.J.1    Mier, J.2    Logan, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.