Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis

Journal of Immunology

Volumn 178, Issue 6, 2007, Pages 3427-3436

  Hildner, Kai M ^a   Schirmacher, Peter ^b   Atreya, Imke ^a   Dittmayer, Maria ^a   Bartsch, Brigitte ^a   Galle, Peter R ^a   Wirtz, Stefan ^a   Neurath, Markus F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CD11B ANTIGEN; COLLAGEN; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; STAT4 PROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CHRONIC ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; IMMUNOPATHOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; TH1 CELL; WILD TYPE;

EID: 33947257812     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.6.3427     Document Type: Article

References (45)

1. Jenkins, J. K., K. J. Hardy, and R. W. McMurray. 2002. The pathogenesis of rheumatoid arthritis: a guide to therapy. Am. J. Med. Sci. 323: 171-180.
2. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14: 397-440.
3. Arend, W. P., and J. M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor a in rheumatoid arthritis. Arthritis Rheum. 38: 151-160.
4. O'Dell, J. R. 2004. Therapeutic strategies for rheumatoid arthritis. N. Engl. J. Med. 350: 2591-2602.
5. Pollard, L., and E. Choy. 2005. Rheumatoid arthritis: non-tumor necrosis factor targets. Curr. Opin. Rheumatol. 17: 242-246.
6. Furst, D. E., F. C. Breedveld, J. R. Kalden, J. S. Smolen, G. R. Burmester, J. W. Bijlsma, M. Dougados, P. Emery, E. C. Keystone, L. Klareskog, and P. J. Mease. 2004. Updated consensus statement on biological agents, specifically tumour necrosis factor α (TNFα) blocking agents and interleukin-1 receptor antagonist (IL-1ra), for the treatment of rheumatic diseases, 2004. Ann. Rheum. Dis. 63(Suppl. 2): ii2-ii12.
7. Van Boxel, J. A., and S. A. Paget. 1975. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N. Engl. J. Med. 293: 517-520.
8. + T-lymphocyte subsets in inflammatory rheumatic diseases. Am. J. Med. 84: 817-825.
9. Kohem, C. L., R. I. Brezinschek, H. Wisbey, C. Tortorella, P. E. Lipsky, and N. Oppenheimer-Marks. 1996. Enrichment of differentiated CD45RBdim. Arthritis Rheum. 39: 844-854.
10. Simon, A. K., E. Seipelt, and J. Sieper. 1994. Divergent T-cell cytokine patterns in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 91: 8562-8566.
11. Dolhain, R. J., A. N. van der Heiden, N. T. ter Haar, F. C. Breedveld, and A. M. Miltenburg. 1996. Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum. 39: 1961-1969.
12. Ziolkowska, M., A. Koc, G. Luszczykiewicz, K. Ksiezopolska-Pietrzak, E. Klimczak, H. Chwalinska-Sadowska, and W. Maslinski. 2000. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol. 164: 2832-2838.
13. Aarvak, T., M. Chabaud, P. Miossec, and J. B. Natvig. 1999. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162: 1246-1251.
14. Luross, I. A., and N. A. Williams. 2001. The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 103: 407-416.
15. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933-944.
16. Trinchieri, G., S. Pflanz, and R. A. Kastelein. 2003. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19: 641-644.
17. Murphy, C. A., C. L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R. A. Kastelein, J. D. Sedgwick, and D. J. Cua. 2003. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198: 1951-1957.
18. Becher, B., B. G. Durell, and R. J. Noelle. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110: 493-497.
19. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
20. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6: 1123-1132.
21. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian, and C. Dong. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6: 1133-1141.
22. Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168: 5699-5708.
23. Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
24. Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177.
25. Neurath, M. F., K. Hildner, C. Becker, J. F. Schlaak, K. Barbulescu, T. Germann, E. Schmitt, P. Schirmacher, S. Haralambous, M. Pasparakis, et al. 1999. Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression. Clin. Exp. Immunol. 115: 42-55.
26. + T lymphocytes. J. Immunol. 160: 3642-3647.
27. + T cells that respond to bacterial antigens. J. Immunol. 162: 1884-1888.
28. Frucht, D. M., M. Aringer, J. Galon, C. Danning, M. Brown, S. Fan, M. Centola, C. Y. Wu, N. Yamada, H. El Gabalawy, and J. J. O'Shea. 2000. Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J. Immunol. 164: 4659-4664.
29. + T cells through Stat1-dependent and independent mechanisms. Proc. Natl. Acad. Sci. USA 100: 15047-15052.
30. Wang, K. S., J. Ritz, and D. A. Frank. 1999. IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells. J. Immunol. 162: 299-304.
31. Strengell, M., S. Matikainen, J. Siren, A. Lehtonen, D. Foster, I. Julkunen, and T. Sareneva. 2003. IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells. J. Immunol. 170: 5464-5469.
32. Malfait, A. M., D. M. Butler, D. H. Presky, R. N. Maini, F. M. Brennan, and M. Feldmann. 1998. Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin. Exp. Immunol. 111: 377-383.
33. Joosten, L. A., E. Lubberts, M. M. Helsen, and W. B. van den Berg. 1997. Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J. Immunol. 159: 4094-4102.
34. Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156: 5-7.
35. Willenborg, D. O., S. Fordham, C. C. Bernard, W. B. Cowden, and I. A. Ramshaw. 1996. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157: 3223-3227.
36. Zhang, G. X., B. Gran, S. Yu, J. Li, I. Siglienti, X. Chen, M. Kamoun, and A. Rostami. 2003. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-β 2-deficieat mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 170: 2153-2160.
37. de Hooge, A. S., F. A. van de Loo, M. I. Koenders, M. B. Bennink, O. J. Arntz, T. Kolbe, and W. B. van den Berg. 2004. Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum. 50: 2014-2023.
38. McIntyre, K. W., D. J. Shuster, K. M. Gillooly, R. R. Warrier, S. E. Connaughton, L. B. Hall, L. H. Arp, M. K. Gately, and J. Magram. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur. J. Immunol. 26: 2933-2938.
39. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240.
40. Chitnis, T., N. Najafian, C. Benou, A. D. Salama, M. J. Grusby, M. H. Sayegh, and S. J. Khoury. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108: 739-747.
41. Afanasyeva, M., Y. Wang, Z. Kaya, E. A. Stafford, K. M. Dohmen, A. A. Sadighi Akha, and N. R. Rose. 2001. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway. Circulation 104: 3145-3151.
42. Finnegan, A., M. J. Grusby, C. D. Kaplan, S. K. O'Neill, H. Eibel, T. Koreny, M. Czipri, K. Mikecz, and J. Zhang. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J. Immunol. 169: 3345-3352.
43. McInnes, I. B., J. al Mughales, M. Field, B. P. Leung, F. P. Huang, R. Dixon, R. D. Sturrock, P. C. Wilkinson, and F. Y. Liew. 1996. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat. Med. 2: 175-182.
44. Marinova-Mutafchieva, L., R. O. Williams, L. J. Mason, C. Mauri, M. Feldmann, and R. N. Maini. 1997. Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin. Exp. Immunol. 107: 507-512.
45. Aggarwal, S., N. Ghilardi, M. H. Xie, F. J. de Sauvage, and A. L. Gurney. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278: 1910-1914.