Effects of heterodimerization and proteolytic processing on Derrière and Nodal activity: Implications for mesoderm induction in Xenopus

Development

Volumn 129, Issue 13, 2002, Pages 3089-3103

  Eimon, Peter M ^a   Harland, Richard M ^a  

^a University of California Berkeley   (United States)

Author keywords

Bmp; Bone morphogenetic protein; Cerberus; Derri re; Dominant negative; Heterodimer; Mesoderm induction; Nodal; Proteolytic processing; Xenopus laevis; Xnr

Indexed keywords

BONE MORPHOGENETIC PROTEIN; LIGAND; MUTANT PROTEIN; PROTEIN DERRIERE; PROTEIN NODAL; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

CONTROLLED STUDY; DIMERIZATION; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; FEEDBACK SYSTEM; MESODERM; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; DIMERIZATION; EMBRYO, NONMAMMALIAN; EMBRYONIC INDUCTION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; GROWTH SUBSTANCES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESODERM; MOLECULAR SEQUENCE DATA; PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; XENOPUS; XENOPUS PROTEINS;

CERBERUS; VERTEBRATA; XENOPUS LAEVIS;

EID: 0036337994     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (87)

1. Endodermal Nodal-related signals and mesoderm induction in Xenopus
2. Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer
3. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
4. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development
5. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
6. Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo
7. Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development
8. A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis
9. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus
10. Mode of action of VegT in mesoderm and endoderm formation
11. Posterior expression of a homeobox gene in early Xenopus embryos
12. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
13. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases
14. BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development
15. The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor
16. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
17. Processing of transforming growth factor beta 1 precursor by human furin convertase
18. Endogenous patterns of TGFbeta superfarmly signaling during early Xenopus development
19. Zebrafish organizer development and germ-layer formation require nodal-related signals
20. Requirement for activin A and transforming growth factor-β1 pro-regions in homodimer assembly
21. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
22. The TGF-beta family member derriere is involved in regulation of the establishment of left-right asymmetry
23. Neural induction
24. Formation and function of Spemann's organizer
25. Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction
26. Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system
27. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
28. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
29. A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation
30. The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities
31. Xsox17alpha and -beta mediate endoderm formation in Xenopus
32. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
33. Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer
34. Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos
35. Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo
36. Vertebrate mesendoderm induction and patterning
37. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors
38. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs
39. FGF signaling restricts the primary blood islands to ventral mesoderm
40. Use of dominant negative constructs to modulate gene expression
41. Neural induction by the secreted polypeptide noggin
42. Timing of endogenous activin-like signals and regional specification of the Xenopus embryo
43. Dominant negative mutants of transforming growth factor-β1 inhibit the secretion of different transforming growth factor-β isoforms
44. Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation
45. XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue
46. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
47. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
48. Early posterior/ventral fate specification in the vertebrate embryo
49. Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos
50. Multiple nodal-related genes act coordinately in Xenopus embryogenesis
51. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis
52. Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1
53. Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols
54. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
55. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP, and Wnt signals
56. Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs
57. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
58. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
59. Nodal signalling in vertebrate development
60. Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos
61. A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathway
62. Mesoderm induction in early Xenopus embryos by heparin-binding growth factors
63. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
64. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
65. A nodal-related gene defines a physical and functional domain within the Spemann organizer
66. The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation
67. Derriere: A TGF-beta family member required for posterior development in Xenopus
68. Mesoderm induction by BMP-4 and -7 heterodimers
69. Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
70. Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center
71. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction
72. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
73. Processed Vg1 protein is an axial mesoderm inducer in Xenopus
74. Lefty proteins exhibit unique processing and activate the MAPK pathway
75. Molecular mechanisms of Spemann's organizer formation: Conserved growth factor synergy between Xenopus and mouse
76. Induction of epidermis and inhibition of neural fate by Bmp-4
77. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication
78. Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: The role of maternal activin
79. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis
80. A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos
81. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
82. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos
83. Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning
84. The Spemann organizer signal noggin binds and inactivates bone morphogenefic protein 4
85. Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways