메뉴 건너뛰기




Volumn 5, Issue 16, 2006, Pages 1740-1743

The problem of cancer dormancy: Understanding the basic mechanisms and identifying therapeutic opportunities

Author keywords

Angiogenesis; Metastasis; Quiescence; Signal transduction; Stem cells

Indexed keywords

CYTOKERATIN 18; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; MYC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UROKINASE RECEPTOR; VASCULOTROPIN INHIBITOR;

EID: 33748931283     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.16.3165     Document Type: Review
Times cited : (55)

References (52)
  • 1
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4:448-56.
    • (2004) Nat Rev Cancer , vol.4 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 3
    • 0034865182 scopus 로고    scopus 로고
    • Early cancer cell dissemination and late metastatic relapse: Clinical reflections and biological approaches to the dormancy problem in patients
    • Riethmuller G, Klein CA. Early cancer cell dissemination and late metastatic relapse: Clinical reflections and biological approaches to the dormancy problem in patients. Semin Cancer Biol 2001; 11:307-11.
    • (2001) Semin Cancer Biol , vol.11 , pp. 307-311
    • Riethmuller, G.1    Klein, C.A.2
  • 4
    • 0034865262 scopus 로고    scopus 로고
    • Tumour dormancy: Findings and hypotheses from clinical research on breast cancer
    • Demicheli R. Tumour dormancy: Findings and hypotheses from clinical research on breast cancer. Semin Cancer Biol 2001; 11:297-306.
    • (2001) Semin Cancer Biol , vol.11 , pp. 297-306
    • Demicheli, R.1
  • 5
    • 24044520722 scopus 로고    scopus 로고
    • Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process
    • Demicheli R, Miceli R, Moliterni A, Zambetti M, Hrushesky WJ, Retsky MW, Valagussa P, Bonadonna G. Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. Ann Oncol 2005; 16:1449-57.
    • (2005) Ann Oncol , vol.16 , pp. 1449-1457
    • Demicheli, R.1    Miceli, R.2    Moliterni, A.3    Zambetti, M.4    Hrushesky, W.J.5    Retsky, M.W.6    Valagussa, P.7    Bonadonna, G.8
  • 7
    • 17744362473 scopus 로고    scopus 로고
    • Gene profiling in squamous cell carcinoma of the head and neck
    • Akervall J. Gene profiling in squamous cell carcinoma of the head and neck. Cancer Metastasis Rev 2005; 24:87-94.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 87-94
    • Akervall, J.1
  • 9
    • 5644222639 scopus 로고    scopus 로고
    • Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
    • Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 2004; 64:7336-45.
    • (2004) Cancer Res , vol.64 , pp. 7336-7345
    • Aguirre-Ghiso, J.A.1    Ossowski, L.2    Rosenbaum, S.K.3
  • 11
    • 0034860742 scopus 로고    scopus 로고
    • Dormancy in a model of murine B cell lymphoma
    • Uhr JW, Marches R. Dormancy in a model of murine B cell lymphoma. Semin Cancer Biol 2001; 11:277-83.
    • (2001) Semin Cancer Biol , vol.11 , pp. 277-283
    • Uhr, J.W.1    Marches, R.2
  • 12
    • 33748937854 scopus 로고    scopus 로고
    • Dormancy of solitary metastatic cells
    • In Press
    • Townson JL, Chambers AF. Dormancy of solitary metastatic cells. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Townson, J.L.1    Chambers, A.F.2
  • 14
    • 33748923637 scopus 로고    scopus 로고
    • Dormant tumors awaken by a short-term angiogenic burst: The spike hypothesis
    • In Press
    • Indraccolo S, Favaro E, Amadori A. Dormant tumors awaken by a short-term angiogenic burst: The spike hypothesis. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Indraccolo, S.1    Favaro, E.2    Amadori, A.3
  • 15
    • 33748941734 scopus 로고    scopus 로고
    • Addressing the role of cell adhesion in tumor cell dormancy
    • In Press
    • White DE, Rayment JH, Muller W. Addressing the role of cell adhesion in tumor cell dormancy. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • White, D.E.1    Rayment, J.H.2    Muller, W.3
  • 16
    • 33748932676 scopus 로고    scopus 로고
    • Urokinase-receptor (u-PAR)-an essential player in multiple games of cancer: A review on its role in tumor progression, invasion, metastasis, proliferation/dormancy, clinical outcome and minimal residual disease
    • In Press
    • Laufs S, Schumacher J, Allgayer H. Urokinase-receptor (u-PAR)-an essential player in multiple games of cancer: A review on its role in tumor progression, invasion, metastasis, proliferation/dormancy, clinical outcome and minimal residual disease. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Laufs, S.1    Schumacher, J.2    Allgayer, H.3
  • 17
    • 33748940402 scopus 로고    scopus 로고
    • Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch
    • In Press
    • Naumov GN, Akslen LA, Folkman J. Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Naumov, G.N.1    Akslen, L.A.2    Folkman, J.3
  • 18
    • 33748924308 scopus 로고    scopus 로고
    • Systemic cancer progression and tumor dormancy: Mathematical models meet single cell genomics
    • In Press
    • Klein CA, Hölzel D. Systemic cancer progression and tumor dormancy: Mathematical models meet single cell genomics. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Klein, C.A.1    Hölzel, D.2
  • 19
    • 33748923798 scopus 로고    scopus 로고
    • Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy
    • In Press
    • Ranganathan AC, Adam AP, Aguirre-Ghiso JA. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Ranganathan, A.C.1    Adam, A.P.2    Aguirre-Ghiso, J.A.3
  • 20
    • 33748934199 scopus 로고    scopus 로고
    • Tumor dormancy: Death and resurrection of cancer as seen through transgenic mouse models
    • In Press
    • Felsher DW. Tumor dormancy: Death and resurrection of cancer as seen through transgenic mouse models. Cell Cycle 2006; In Press.
    • (2006) Cell Cycle
    • Felsher, D.W.1
  • 21
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre-Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999; 147:89-104.
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre-Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 25
    • 32944478891 scopus 로고    scopus 로고
    • Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    • Ranganathan AC, Zhang L, Adam AP, Aguirre-Ghiso JA. Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res 2006; 66:1702-11.
    • (2006) Cancer Res , vol.66 , pp. 1702-1711
    • Ranganathan, A.C.1    Zhang, L.2    Adam, A.P.3    Aguirre-Ghiso, J.A.4
  • 26
    • 19644376774 scopus 로고    scopus 로고
    • Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy
    • Shachaf CM, Felsher DW. Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy. Cancer Res 2005; 65:4471-4.
    • (2005) Cancer Res , vol.65 , pp. 4471-4474
    • Shachaf, C.M.1    Felsher, D.W.2
  • 28
    • 0030984295 scopus 로고    scopus 로고
    • Urokinase plasminogen activator receptor (uPA-R): One potential characteristic of metastatic phenotypes in minimal residual tumor disease
    • Allgayer H, Heiss MM, Riesenberg R, Grutzner KU, Tarabichi A, Babic R, Schildberg FW. Urokinase plasminogen activator receptor (uPA-R): One potential characteristic of metastatic phenotypes in minimal residual tumor disease. Cancer Res 1997; 57:1394-9.
    • (1997) Cancer Res , vol.57 , pp. 1394-1399
    • Allgayer, H.1    Heiss, M.M.2    Riesenberg, R.3    Grutzner, K.U.4    Tarabichi, A.5    Babic, R.6    Schildberg, F.W.7
  • 29
    • 0028885643 scopus 로고
    • Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer
    • Heiss MM, Allgayer H, Gruetzner KU, Funke I, Babic R, Jauch KW, Schildberg FW. Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer. Nat Med 1995; 1:1035-9.
    • (1995) Nat Med , vol.1 , pp. 1035-1039
    • Heiss, M.M.1    Allgayer, H.2    Gruetzner, K.U.3    Funke, I.4    Babic, R.5    Jauch, K.W.6    Schildberg, F.W.7
  • 30
    • 0030956119 scopus 로고    scopus 로고
    • Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy
    • Yu W, Kim J, Ossowski L. Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J Cell Biol 1997; 137:767-77.
    • (1997) J Cell Biol , vol.137 , pp. 767-777
    • Yu, W.1    Kim, J.2    Ossowski, L.3
  • 31
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 2003; 63:1684-95.
    • (2003) Cancer Res , vol.63 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 33
    • 22244456107 scopus 로고    scopus 로고
    • TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts
    • Salm SN, Burger PE, Coetzee S, Goto K, Moscatelli D, Wilson EL. TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts. J Cell Biol 2005; 170:81-90.
    • (2005) J Cell Biol , vol.170 , pp. 81-90
    • Salm, S.N.1    Burger, P.E.2    Coetzee, S.3    Goto, K.4    Moscatelli, D.5    Wilson, E.L.6
  • 34
    • 0028018343 scopus 로고
    • Persistence of dormant leukemic progenitors during interferon-induced remission in chronic myelogenous leukemia. Analysis by polymerase chain reaction of individual colonies
    • Talpaz M, Estrov Z, Kantarjian H, Ku S, Foteh A, Kurzrock R. Persistence of dormant leukemic progenitors during interferon-induced remission in chronic myelogenous leukemia. Analysis by polymerase chain reaction of individual colonies. J Clin Invest 1994; 94:1383-9.
    • (1994) J Clin Invest , vol.94 , pp. 1383-1389
    • Talpaz, M.1    Estrov, Z.2    Kantarjian, H.3    Ku, S.4    Foteh, A.5    Kurzrock, R.6
  • 35
    • 0034747733 scopus 로고    scopus 로고
    • Occult micrometastasis: Enrichment, identification and characterization of single disseminated tumour cells
    • Pantel K, Otte M. Occult micrometastasis: Enrichment, identification and characterization of single disseminated tumour cells. Semin Cancer Biol 2001; 11:327-37.
    • (2001) Semin Cancer Biol , vol.11 , pp. 327-337
    • Pantel, K.1    Otte, M.2
  • 37
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 39
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004; 6:159-70.
    • (2004) Cancer Cell , vol.6 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3    Hassell, J.A.4    Blaess, S.5    Mueller, U.6    Muller, W.J.7
  • 40
    • 0038386618 scopus 로고    scopus 로고
    • Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence
    • Tilli MT, Furth PA. Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence. Breast Cancer Res 2003; 5:202-5.
    • (2003) Breast Cancer Res , vol.5 , pp. 202-205
    • Tilli, M.T.1    Furth, P.A.2
  • 42
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002; 29:15-8.
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 43
    • 0026362940 scopus 로고
    • Switch to the angiogenic phenotype during tumorigenesis
    • Folkman J, Hanahan D. Switch to the angiogenic phenotype during tumorigenesis. Princess Takamatsu Symp 1991; 22:339-47.
    • (1991) Princess Takamatsu Symp , vol.22 , pp. 339-347
    • Folkman, J.1    Hanahan, D.2
  • 44
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
    • Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 1997; 137:231-45.
    • (1997) J Cell Biol , vol.137 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 45
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu D, Aguirre-Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002; 1:445-57.
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre-Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 46
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 2001; 12:863-79.
    • (2001) Mol Biol Cell , vol.12 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 47
    • 0042972556 scopus 로고    scopus 로고
    • Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
    • Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell 2003; 3:219-31.
    • (2003) Cancer Cell , vol.3 , pp. 219-231
    • Watnick, R.S.1    Cheng, Y.N.2    Rangarajan, A.3    Ince, T.A.4    Weinberg, R.A.5
  • 48
    • 0033587731 scopus 로고    scopus 로고
    • Cancer dormancy and cell signaling: Induction of p21(waf1) initiated by membrane IgM engagement increases survival of B lymphoma cells
    • Marches R, Hsueh R, Uhr JW. Cancer dormancy and cell signaling: Induction of p21(waf1) initiated by membrane IgM engagement increases survival of B lymphoma cells. Proc Natl Acad Sci USA 1999; 96:8711-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8711-8715
    • Marches, R.1    Hsueh, R.2    Uhr, J.W.3
  • 49
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. Faseb J 2004; 18:338-40.
    • (2004) Faseb J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 52
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 2002; 20:1S-13S.
    • (2002) J Clin Oncol , vol.20
    • Mendelsohn, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.