-
1
-
-
33845883023
-
Paleontological evidence to date the tree of life
-
Benton MJ, Donoghue PC (2007) Paleontological evidence to date the tree of life. Mol Biol Evol 24:26-53
-
(2007)
Mol Biol Evol
, vol.24
, pp. 26-53
-
-
Benton, M.J.1
Donoghue, P.C.2
-
2
-
-
0344412889
-
Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization
-
Biebermann H, Krude H, Elsner A, Chubanov V, Gudermann T, Gruters A (2003) Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes 52:2984-2988
-
(2003)
Diabetes
, vol.52
, pp. 2984-2988
-
-
Biebermann, H.1
Krude, H.2
Elsner, A.3
Chubanov, V.4
Gudermann, T.5
Gruters, A.6
-
3
-
-
3042842589
-
A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution
-
Bielawski JP, Yang Z (2004) A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution. J Mol Evol 59:121-132
-
(2004)
J Mol Evol
, vol.59
, pp. 121-132
-
-
Bielawski, J.P.1
Yang, Z.2
-
4
-
-
34047108602
-
The delayed rise of present-day mammals
-
Bininda-Emonds OR, Cardillo M, Jones KE, MacPhee RD, Beck RM, Grenyer R, Price SA, Vos RA, Gittleman JL, Purvis A (2007) The delayed rise of present-day mammals. Nature 446:507-512
-
(2007)
Nature
, vol.446
, pp. 507-512
-
-
Bininda-Emonds, O.R.1
Cardillo, M.2
Jones, K.E.3
MacPhee, R.D.4
Beck, R.M.5
Grenyer, R.6
Price, S.A.7
Vos, R.A.8
Gittleman, J.L.9
Purvis, A.10
-
5
-
-
44949129000
-
Assessing the evolutionary impact of amino acid mutations in the human genome
-
Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD (2008) Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet 4:e1000083
-
(2008)
PLoS Genet
, vol.4
-
-
Boyko, A.R.1
Williamson, S.H.2
Indap, A.R.3
Degenhardt, J.D.4
Hernandez, R.D.5
Lohmueller, K.E.6
Adams, M.D.7
Schmidt, S.8
Sninsky, J.J.9
Sunyaev, S.R.10
White, T.J.11
Nielsen, R.12
Clark, A.G.13
Bustamante, C.D.14
-
6
-
-
0037456733
-
Binge eating as a major phenotype of melanocortin 4 receptor gene mutations
-
Branson R, Potoczna N, Kral JG, Lentes KU, Hoehe MR, Horber FF (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348:1096-1103
-
(2003)
N Engl J Med
, vol.348
, pp. 1096-1103
-
-
Branson, R.1
Potoczna, N.2
Kral, J.G.3
Lentes, K.U.4
Hoehe, M.R.5
Horber, F.F.6
-
7
-
-
27144539145
-
Natural selection on protein-coding genes in the human genome
-
Bustamante CD, Fledel-Alon A, Williamson S, Nielsen R, Todd Hubisz M, Glanowski S, Tanenbaum DM, White TJ, Sninsky JJ, Hernandez RD, Civello D, Adams MD, Cargill M, Clark AG (2005) Natural selection on protein-coding genes in the human genome. Nature 437:1153
-
(2005)
Nature
, vol.437
, pp. 1153
-
-
Bustamante, C.D.1
Fledel-Alon, A.2
Williamson, S.3
Nielsen, R.4
Todd Hubisz, M.5
Glanowski, S.6
Tanenbaum, D.M.7
White, T.J.8
Sninsky, J.J.9
Hernandez, R.D.10
Civello, D.11
Adams, M.D.12
Cargill, M.13
Clark, A.G.14
-
8
-
-
31544465224
-
The melanocortin system and energy balance
-
Butler AA (2006) The melanocortin system and energy balance. Peptides 27:281-290
-
(2006)
Peptides
, vol.27
, pp. 281-290
-
-
Butler, A.A.1
-
9
-
-
0038051071
-
Knockout studies defining different roles for melanocortin receptors in energy homeostasis
-
Butler AA, Cone RD (2003) Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Ann N Y Acad Sci 994:240-245
-
(2003)
Ann N Y Acad Sci
, vol.994
, pp. 240-245
-
-
Butler, A.A.1
Cone, R.D.2
-
10
-
-
0037066430
-
A human genome diversity cell line panel
-
Cann HM, de Toma C, Cazes L, Legrand MF, Morel V, Piouffre L, Bodmer J, Bodmer WF, Bonne-Tamir B, Cambon-Thomsen A, Chen Z, Chu J, Carcassi C, Contu L, Du R, Excoffier L, Ferrara GB, Friedlaender JS, Groot H, Gurwitz D, Jenkins T, Herrera RJ, Huang X, Kidd J, Kidd KK, Langaney A, Lin AA, Mehdi SQ, Parham P, Piazza A, Pistillo MP, Qian Y, Shu Q, Xu J, Zhu S, Weber JL, Greely HT, Feldman MW, Thomas G, Dausset J, Cavalli-Sforza LL (2002) A human genome diversity cell line panel. Science 296:261-262
-
(2002)
Science
, vol.296
, pp. 261-262
-
-
Cann, H.M.1
de Toma, C.2
Cazes, L.3
Legrand, M.F.4
Morel, V.5
Piouffre, L.6
Bodmer, J.7
Bodmer, W.F.8
Bonne-Tamir, B.9
Cambon-Thomsen, A.10
Chen, Z.11
Chu, J.12
Carcassi, C.13
Contu, L.14
Du, R.15
Excoffier, L.16
Ferrara, G.B.17
Friedlaender, J.S.18
Groot, H.19
Gurwitz, D.20
Jenkins, T.21
Herrera, R.J.22
Huang, X.23
Kidd, J.24
Kidd, K.K.25
Langaney, A.26
Lin, A.A.27
Mehdi, S.Q.28
Parham, P.29
Piazza, A.30
Pistillo, M.P.31
Qian, Y.32
Shu, Q.33
Xu, J.34
Zhu, S.35
Weber, J.L.36
Greely, H.T.37
Feldman, M.W.38
Thomas, G.39
Dausset, J.40
Cavalli-Sforza, L.L.41
more..
-
11
-
-
43249086697
-
Analysis of chimpanzee history based on genome sequence alignments
-
Caswell JL, Mallick S, Richter DJ, Neubauer J, Schirmer C, Gnerre S, Reich D (2008) Analysis of chimpanzee history based on genome sequence alignments. PLoS Genet 4:e1000057
-
(2008)
PLoS Genet
, vol.4
-
-
Caswell, J.L.1
Mallick, S.2
Richter, D.J.3
Neubauer, J.4
Schirmer, C.5
Gnerre, S.6
Reich, D.7
-
12
-
-
0028222304
-
The effect of background selection against deleterious mutations on weakly selected, linked variants
-
Charlesworth B (1994) The effect of background selection against deleterious mutations on weakly selected, linked variants. Genet Res 63:213-227
-
(1994)
Genet Res
, vol.63
, pp. 213-227
-
-
Charlesworth, B.1
-
13
-
-
6344260502
-
Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index
-
Dempfle A, Hinney A, Heinzel-Gutenbrunner M, Raab M, Geller F, Gudermann T, Schafer H, Hebebrand J (2004) Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index. J Med Genet 41:795-800
-
(2004)
J Med Genet
, vol.41
, pp. 795-800
-
-
Dempfle, A.1
Hinney, A.2
Heinzel-Gutenbrunner, M.3
Raab, M.4
Geller, F.5
Gudermann, T.6
Schafer, H.7
Hebebrand, J.8
-
14
-
-
0034905674
-
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children
-
Dubern B, Clement K, Pelloux V, Froguel P, Girardet JP, Guy-Grand B, Tounian P (2001) Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. J Pediatr 139:204-219
-
(2001)
J Pediatr
, vol.139
, pp. 204-219
-
-
Dubern, B.1
Clement, K.2
Pelloux, V.3
Froguel, P.4
Girardet, J.P.5
Guy-Grand, B.6
Tounian, P.7
-
15
-
-
13244255415
-
MUSCLE: A multiple sequence alignment method with reduced time and space complexity
-
Edgar RC (2004) MUSCLE: A multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 5:113
-
(2004)
BMC Bioinformatics
, vol.5
, pp. 113
-
-
Edgar, R.C.1
-
16
-
-
33748473348
-
The genomic rate of adaptive evolution
-
Eyre-Walker A (2006) The genomic rate of adaptive evolution. Trends Ecol Evol 21:569-575
-
(2006)
Trends Ecol Evol
, vol.21
, pp. 569-575
-
-
Eyre-Walker, A.1
-
17
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S (2000) Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.2
Keogh, J.M.3
Aminian, S.4
Jebb, S.A.5
Butler, G.6
Cheetham, T.7
O'Rahilly, S.8
-
18
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095
-
(2003)
N Engl J Med
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
19
-
-
0034924997
-
Positive and negative selection on the human genome
-
Fay JC, Wyckoff GJ, Wu CI (2001) Positive and negative selection on the human genome. Genetics 158:1227-1234
-
(2001)
Genetics
, vol.158
, pp. 1227-1234
-
-
Fay, J.C.1
Wyckoff, G.J.2
Wu, C.I.3
-
20
-
-
0003437299
-
-
Distributed by the author. Department of Genome Sciences, University of Washington, Seattle
-
Felsenstein J (2004) PHYLIP (Phylogeny Inference Package) version 3.6. Distributed by the author. Department of Genome Sciences, University of Washington, Seattle
-
(2004)
PHYLIP (Phylogeny Inference Package) Version 3.6
-
-
Felsenstein, J.1
-
21
-
-
33744551169
-
Demographic history and genetic differentiation in apes
-
Fischer A, Pollack J, Thalmann O, Nickel B, Paabo S (2006) Demographic history and genetic differentiation in apes. Curr Biol 16:1133-1148
-
(2006)
Curr Biol
, vol.16
, pp. 1133-1148
-
-
Fischer, A.1
Pollack, J.2
Thalmann, O.3
Nickel, B.4
Paabo, S.5
-
23
-
-
0028168856
-
A codon-based model of nucleotide substitution for protein-coding DNA sequences
-
Goldman N, Yang Z (1994) A codon-based model of nucleotide substitution for protein-coding DNA sequences. Mol Biol Evol 11:725-736
-
(1994)
Mol Biol Evol
, vol.11
, pp. 725-736
-
-
Goldman, N.1
Yang, Z.2
-
24
-
-
0034351387
-
Likelihood-based tests of topologies in phylogenetics
-
Goldman N, Anderson JP, Rodrigo AG (2000) Likelihood-based tests of topologies in phylogenetics. Syst Biol 49:652-670
-
(2000)
Syst Biol
, vol.49
, pp. 652-670
-
-
Goldman, N.1
Anderson, J.P.2
Rodrigo, A.G.3
-
25
-
-
0033010326
-
Identification and functional analysis of novel human melanocortin-4 receptor variants
-
Gu W, Tu Z, Kleyn PW, Kissebah A, Duprat L, Lee J, Chin W, Maruti S, Deng N, Fisher SL, Franco LS, Burn P, Yagaloff KA, Nathan J, Heymsfield S, Albu J, Pi-Sunyer FX, Allison DB (1999) Identification and functional analysis of novel human melanocortin-4 receptor variants. Diabetes 48:635-639
-
(1999)
Diabetes
, vol.48
, pp. 635-639
-
-
Gu, W.1
Tu, Z.2
Kleyn, P.W.3
Kissebah, A.4
Duprat, L.5
Lee, J.6
Chin, W.7
Maruti, S.8
Deng, N.9
Fisher, S.L.10
Franco, L.S.11
Burn, P.12
Yagaloff, K.A.13
Nathan, J.14
Heymsfield, S.15
Albu, J.16
Pi-Sunyer, F.X.17
Allison, D.B.18
-
26
-
-
39449108661
-
Association of the MC4R V103I polymorphism with the metabolic syndrome: The KORA Study
-
Heid IM, Vollmert C, Kronenberg F, Huth C, Ankerst DP, Luchner A, Hinney A, Bronner G, Wichmann HE, Illig T, Doring A, Hebebrand J (2008) Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring) 16:369-376
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 369-376
-
-
Heid, I.M.1
Vollmert, C.2
Kronenberg, F.3
Huth, C.4
Ankerst, D.P.5
Luchner, A.6
Hinney, A.7
Bronner, G.8
Wichmann, H.E.9
Illig, T.10
Doring, A.11
Hebebrand, J.12
-
27
-
-
0033343736
-
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Nottebom K, Heibult O, Becker I, Ziegler A, Gerber G, Sina M, Gorg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J (1999) Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 84:1483-1486
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Nottebom, K.3
Heibult, O.4
Becker, I.5
Ziegler, A.6
Gerber, G.7
Sina, M.8
Gorg, T.9
Mayer, H.10
Siegfried, W.11
Fichter, M.12
Remschmidt, H.13
Hebebrand, J.14
-
28
-
-
0141564582
-
Melanocortin-4 receptor gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
-
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schafer H, Gudermann T, Hebebrand J (2003) Melanocortin-4 receptor gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 88:4258-4267
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4258-4267
-
-
Hinney, A.1
Hohmann, S.2
Geller, F.3
Vogel, C.4
Hess, C.5
Wermter, A.K.6
Brokamp, B.7
Goldschmidt, H.8
Siegfried, W.9
Remschmidt, H.10
Schafer, H.11
Gudermann, T.12
Hebebrand, J.13
-
29
-
-
33646423288
-
Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany
-
Hinney A, Bettecken T, Tarnow P, Brumm H, Reichwald K, Lichtner P, Scherag A, Nguyen TT, Schlumberger P, Rief W, Vollmert C, Illig T, Wichmann HE, Schafer H, Platzer M, Biebermann H, Meitinger T, Hebebrand J (2006) Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J Clin Endocrinol Metab 91:1761-1769
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 1761-1769
-
-
Hinney, A.1
Bettecken, T.2
Tarnow, P.3
Brumm, H.4
Reichwald, K.5
Lichtner, P.6
Scherag, A.7
Nguyen, T.T.8
Schlumberger, P.9
Rief, W.10
Vollmert, C.11
Illig, T.12
Wichmann, H.E.13
Schafer, H.14
Platzer, M.15
Biebermann, H.16
Meitinger, T.17
Hebebrand, J.18
-
30
-
-
0036184745
-
Generating samples under a Wright-Fisher neutral model of genetic variation
-
Hudson RR (2002) Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18:337-348
-
(2002)
Bioinformatics
, vol.18
, pp. 337-348
-
-
Hudson, R.R.1
-
31
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Lee, F.14
-
32
-
-
0038586483
-
A genome scan to detect candidate regions influenced by local natural selection in human populations
-
Kayser M, Brauer S, Stoneking M (2003) A genome scan to detect candidate regions influenced by local natural selection in human populations. Mol Biol Evol 20:893-900
-
(2003)
Mol Biol Evol
, vol.20
, pp. 893-900
-
-
Kayser, M.1
Brauer, S.2
Stoneking, M.3
-
33
-
-
0024307824
-
Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in hominoidea
-
Kishino H, Hasegawa M (1989) Evaluation of the maximum likelihood estimate of the evolutionary tree topologies from DNA sequence data, and the branching order in hominoidea. J Mol Evol 29:170-179
-
(1989)
J Mol Evol
, vol.29
, pp. 170-179
-
-
Kishino, H.1
Hasegawa, M.2
-
34
-
-
0036094522
-
A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity
-
Kobayashi H, Ogawa Y, Shintani M, Ebihara K, Shimodahira M, Iwakura T, Hino M, Ishihara T, Ikekubo K, Kurahachi H, Nakao K (2002) A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity. Diabetes 51:243-246
-
(2002)
Diabetes
, vol.51
, pp. 243-246
-
-
Kobayashi, H.1
Ogawa, Y.2
Shintani, M.3
Ebihara, K.4
Shimodahira, M.5
Iwakura, T.6
Hino, M.7
Ishihara, T.8
Ikekubo, K.9
Kurahachi, H.10
Nakao, K.11
-
35
-
-
37549004740
-
Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri
-
Kobayashi Y, Tsuchiya K, Yamanome T, Schioth HB, Kawauchi H, Takahashi A (2008) Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri. Gen Comp Endocrinol 155:280-287
-
(2008)
Gen Comp Endocrinol
, vol.155
, pp. 280-287
-
-
Kobayashi, Y.1
Tsuchiya, K.2
Yamanome, T.3
Schioth, H.B.4
Kawauchi, H.5
Takahashi, A.6
-
36
-
-
3242810318
-
MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment
-
Kumar S, Tamura K, Nei M (2004) MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5:150-163
-
(2004)
Brief Bioinform
, vol.5
, pp. 150-163
-
-
Kumar, S.1
Tamura, K.2
Nei, M.3
-
37
-
-
12244281827
-
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity
-
Larsen LH, Echwald SM, Sorensen TI, Andersen T, Wulff BS, Pedersen O (2005) Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab 90:219-224
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 219-224
-
-
Larsen, L.H.1
Echwald, S.M.2
Sorensen, T.I.3
Andersen, T.4
Wulff, B.S.5
Pedersen, O.6
-
38
-
-
39749181521
-
Worldwide human relationships inferred from genome-wide patterns of variation
-
Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM (2008) Worldwide human relationships inferred from genome-wide patterns of variation. Science 319:1100-1104
-
(2008)
Science
, vol.319
, pp. 1100-1104
-
-
Li, J.Z.1
Absher, D.M.2
Tang, H.3
Southwick, A.M.4
Casto, A.M.5
Ramachandran, S.6
Cann, H.M.7
Barsh, G.S.8
Feldman, M.9
Cavalli-Sforza, L.L.10
Myers, R.M.11
-
39
-
-
0344412890
-
The human MC4R promoter: Characterization and role in obesity
-
Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C (2003) The human MC4R promoter: characterization and role in obesity. Diabetes 52:2996-3000
-
(2003)
Diabetes
, vol.52
, pp. 2996-3000
-
-
Lubrano-Berthelier, C.1
Cavazos, M.2
Le Stunff, C.3
Haas, K.4
Shapiro, A.5
Zhang, S.6
Bougneres, P.7
Vaisse, C.8
-
40
-
-
0036257961
-
Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity
-
Miraglia Del Giudice E, Cirillo G, Nigro V, Santoro N, D'Urso L, Raimondo P, Cozzolino D, Scafato D, Perrone L (2002) Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. Int J Obes Relat Metab Disord 26:647-651
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 647-651
-
-
Miraglia Del Giudice, E.1
Cirillo, G.2
Nigro, V.3
Santoro, N.4
D'Urso, L.5
Raimondo, P.6
Cozzolino, D.7
Scafato, D.8
Perrone, L.9
-
41
-
-
0031972161
-
Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene
-
Nielsen R, Yang Z (1998) Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene. Genetics 148:929-936
-
(1998)
Genetics
, vol.148
, pp. 929-936
-
-
Nielsen, R.1
Yang, Z.2
-
42
-
-
0037927578
-
Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity
-
Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem 278:22939-22945
-
(2003)
J Biol Chem
, vol.278
, pp. 22939-22945
-
-
Nijenhuis, W.A.1
Garner, K.M.2
van Rozen, R.J.3
Adan, R.A.4
-
43
-
-
1942511512
-
Insights into recombination from patterns of linkage disequilibrium in humans
-
Ptak SE, Voelpel K, Przeworski M (2004) Insights into recombination from patterns of linkage disequilibrium in humans. Genetics 167:387-397
-
(2004)
Genetics
, vol.167
, pp. 387-397
-
-
Ptak, S.E.1
Voelpel, K.2
Przeworski, M.3
-
44
-
-
33847673071
-
G protein-coupled time travel: Evolutionary aspects of GPCR research
-
Rompler H, Staubert C, Thor D, Schulz A, Hofreiter M, Schoneberg T (2007) G protein-coupled time travel: Evolutionary aspects of GPCR research. Mol Interv 7:17-25
-
(2007)
Mol Interv
, vol.7
, pp. 17-25
-
-
Rompler, H.1
Staubert, C.2
Thor, D.3
Schulz, A.4
Hofreiter, M.5
Schoneberg, T.6
-
45
-
-
0037147189
-
Genetic structure of human populations
-
Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, Feldman MW (2002) Genetic structure of human populations. Science 298:2381-2385
-
(2002)
Science
, vol.298
, pp. 2381-2385
-
-
Rosenberg, N.A.1
Pritchard, J.K.2
Weber, J.L.3
Cann, H.M.4
Kidd, K.K.5
Zhivotovsky, L.A.6
Feldman, M.W.7
-
46
-
-
33750437374
-
Clines, clusters, and the effect of study design on the inference of human population structure
-
Rosenberg NA, Mahajan S, Ramachandran S, Zhao C, Pritchard JK, Feldman MW (2005) Clines, clusters, and the effect of study design on the inference of human population structure. PLoS Genet 1:e70
-
(2005)
PLoS Genet
, vol.1
-
-
Rosenberg, N.A.1
Mahajan, S.2
Ramachandran, S.3
Zhao, C.4
Pritchard, J.K.5
Feldman, M.W.6
-
47
-
-
0347513220
-
DnaSP, DNA polymorphism analyses by the coalescent and other methods
-
Rozas J, Sanchez-DelBarrio JC, Messeguer X, Rozas R (2003) DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19:2496-2507
-
(2003)
Bioinformatics
, vol.19
, pp. 2496-2507
-
-
Rozas, J.1
Sanchez-DelBarrio, J.C.2
Messeguer, X.3
Rozas, R.4
-
48
-
-
0016374975
-
A highly sensitive adenylate cyclase assay
-
Salomon Y, Londos C, Rodbell M (1974) A highly sensitive adenylate cyclase assay. Anal Biochem 58:541-548
-
(1974)
Anal Biochem
, vol.58
, pp. 541-548
-
-
Salomon, Y.1
Londos, C.2
Rodbell, M.3
-
49
-
-
10744227887
-
Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: Description and functional characterization of a novel mutation
-
Santini F, Maffei M, Ceccarini G, Pelosini C, Scartabelli G, Rosellini V, Chiellini C, Marsili A, Lisi S, Tonacchera M, Agretti P, Chiovato L, Mammoli C, Vitti P, Pinchera A (2004) Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation. J Clin Endocrinol Metab 89:904-908
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 904-908
-
-
Santini, F.1
Maffei, M.2
Ceccarini, G.3
Pelosini, C.4
Scartabelli, G.5
Rosellini, V.6
Chiellini, C.7
Marsili, A.8
Lisi, S.9
Tonacchera, M.10
Agretti, P.11
Chiovato, L.12
Mammoli, C.13
Vitti, P.14
Pinchera, A.15
-
50
-
-
27544497650
-
Calibrating a coalescent simulation of human genome sequence variation
-
Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ, Altshuler D (2005) Calibrating a coalescent simulation of human genome sequence variation. Genome Res 15:1576-1583
-
(2005)
Genome Res
, vol.15
, pp. 1576-1583
-
-
Schaffner, S.F.1
Foo, C.2
Gabriel, S.3
Reich, D.4
Daly, M.J.5
Altshuler, D.6
-
53
-
-
0032766857
-
Multiple comparisons of log-likelihoods with applications to phylogenetic inference
-
Shimodaira H, Hasegawa M (1999) Multiple comparisons of log-likelihoods with applications to phylogenetic inference. Mol Biol Evol 16:1114-1116
-
(1999)
Mol Biol Evol
, vol.16
, pp. 1114-1116
-
-
Shimodaira, H.1
Hasegawa, M.2
-
54
-
-
9644279627
-
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
-
Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C (2004) Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest 114:1158-1164
-
(2004)
J Clin Invest
, vol.114
, pp. 1158-1164
-
-
Srinivasan, S.1
Lubrano-Berthelier, C.2
Govaerts, C.3
Picard, F.4
Santiago, P.5
Conklin, B.R.6
Vaisse, C.7
-
55
-
-
34547839796
-
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: The two facets of a Janus obesity gene
-
Stutzmann F, Vatin V, Cauchi S, Morandi A, Jouret B, Landt O, Tounian P, Levy-Marchal C, Buzzetti R, Pinelli L, Balkau B, Horber F, Bougneres P, Froguel P, Meyre D (2007) Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: The two facets of a Janus obesity gene. Hum Mol Genet 16:1837-1844
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1837-1844
-
-
Stutzmann, F.1
Vatin, V.2
Cauchi, S.3
Morandi, A.4
Jouret, B.5
Landt, O.6
Tounian, P.7
Levy-Marchal, C.8
Buzzetti, R.9
Pinelli, L.10
Balkau, B.11
Horber, F.12
Bougneres, P.13
Froguel, P.14
Meyre, D.15
-
56
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P (2000) Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
57
-
-
1442327719
-
Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese Finnish children and adults
-
Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjorbaek C, Schalin-Jantti C (2004) Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese Finnish children and adults. J Clin Endocrinol Metab 89:940-945
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 940-945
-
-
Valli-Jaakola, K.1
Lipsanen-Nyman, M.2
Oksanen, L.3
Hollenberg, A.N.4
Kontula, K.5
Bjorbaek, C.6
Schalin-Jantti, C.7
-
58
-
-
8544225780
-
Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites
-
Wong WS, Yang Z, Goldman N, Nielsen R (2004) Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites. Genetics 168:1041-1051
-
(2004)
Genetics
, vol.168
, pp. 1041-1051
-
-
Wong, W.S.1
Yang, Z.2
Goldman, N.3
Nielsen, R.4
-
59
-
-
33745036725
-
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist
-
Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C (2006) Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry 45:7277-7288
-
(2006)
Biochemistry
, vol.45
, pp. 7277-7288
-
-
Xiang, Z.1
Litherland, S.A.2
Sorensen, N.B.3
Proneth, B.4
Wood, M.S.5
Shaw, A.M.6
Millard, W.J.7
Haskell-Luevano, C.8
-
60
-
-
0031897964
-
Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
-
Yang Z (1998) Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol Biol Evol 15:568-573
-
(1998)
Mol Biol Evol
, vol.15
, pp. 568-573
-
-
Yang, Z.1
-
61
-
-
34547803197
-
PAML 4: Phylogenetic analysis by maximum likelihood
-
Yang Z (2007) PAML 4: Phylogenetic analysis by maximum likelihood. Mol Biol Evol 24:1586-1591
-
(2007)
Mol Biol Evol
, vol.24
, pp. 1586-1591
-
-
Yang, Z.1
-
62
-
-
0031960185
-
Synonymous and nonsynonymous rate variation in nuclear genes of mammals
-
Yang Z, Nielsen R (1998) Synonymous and nonsynonymous rate variation in nuclear genes of mammals. J Mol Evol 46:409-418
-
(1998)
J Mol Evol
, vol.46
, pp. 409-418
-
-
Yang, Z.1
Nielsen, R.2
-
63
-
-
39749161509
-
Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage
-
Yang Z, Nielsen R (2008) Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage. Mol Biol Evol 25(3):568-579
-
(2008)
Mol Biol Evol
, vol.25
, Issue.3
, pp. 568-579
-
-
Yang, Z.1
Nielsen, R.2
-
64
-
-
16344378246
-
Bayes empirical bayes inference of amino acid sites under positive selection
-
Yang Z, Wong WS, Nielsen R (2005) Bayes empirical bayes inference of amino acid sites under positive selection. Mol Biol Evol 22:1107-1118
-
(2005)
Mol Biol Evol
, vol.22
, pp. 1107-1118
-
-
Yang, Z.1
Wong, W.S.2
Nielsen, R.3
-
65
-
-
0037341511
-
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
-
Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S (2003) Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Hum Mol Genet 12:561-574
-
(2003)
Hum Mol Genet
, vol.12
, pp. 561-574
-
-
Yeo, G.S.1
Lank, E.J.2
Farooqi, I.S.3
Keogh, J.4
Challis, B.G.5
O'Rahilly, S.6
-
66
-
-
43849102865
-
DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC)
-
Unit7 10
-
Yu B, Sawyer NA, Chiu C, Oefner PJ, Underhill PA (2006) DNA mutation detection using denaturing high-performance liquid chromatography (DHPLC). Curr Protoc Hum Genet Chapter 7: Unit7 10
-
(2006)
Curr Protoc Hum Genet Chapter
, vol.7
-
-
Yu, B.1
Sawyer, N.A.2
Chiu, C.3
Oefner, P.J.4
Underhill, P.A.5
|