-
1
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
2
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-1103.
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
-
3
-
-
6344221594
-
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: Report of another case and evaluation of response to four years of leptin therapy
-
Gibson WT, Farooqi IS, Moreau M et al. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab 2004;89:4821-4826.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4821-4826
-
-
Gibson, W.T.1
Farooqi, I.S.2
Moreau, M.3
-
4
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-215.
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
5
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clément K, Vaisse C, Lahlou N et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clément, K.1
Vaisse, C.2
Lahlou, N.3
-
6
-
-
0031980203
-
Heterozygosity for Lep(ob) or Lepr(db) affects body composition and leptin homeostasis in adult mice
-
Chung WK, Belfi K, Chua M et al. Heterozygosity for Lep(ob) or Lepr(db) affects body composition and leptin homeostasis in adult mice. Am J Physiol 1998;274: R985-R990.
-
(1998)
Am J Physiol
, vol.274
-
-
Chung, W.K.1
Belfi, K.2
Chua, M.3
-
7
-
-
0035514934
-
Partial leptin deficiency and human adiposity
-
Farooqi IS, Keogh JM, Kamath S et al. Partial leptin deficiency and human adiposity. Nature 2001;414:34-35.
-
(2001)
Nature
, vol.414
, pp. 34-35
-
-
Farooqi, I.S.1
Keogh, J.M.2
Kamath, S.3
-
8
-
-
0036732501
-
Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil
-
Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord 2002;26:1179-1185.
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 1179-1185
-
-
Mattevi, V.S.1
Zembrzuski, V.M.2
Hutz, M.H.3
-
9
-
-
33749141489
-
Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults
-
van Rossum CT, Pijl H, Adan RA, Hoebee B, Seidell JC. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. Int J Obes (Lond) 2006;30:1522-1528.
-
(2006)
Int J Obes (Lond)
, vol.30
, pp. 1522-1528
-
-
van Rossum, C.T.1
Pijl, H.2
Adan, R.A.3
Hoebee, B.4
Seidell, J.C.5
-
10
-
-
1542300099
-
Molecular screening of the ghrelin gene in Italian obese children: The Leu72Met variant is associated with an earlier onset of obesity
-
Miraglia del Giudice E, Santoro N, Cirillo G et al. Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. Int J Obes Relat Metab Disord 2004;28:447-450.
-
(2004)
Int J Obes Relat Metab Disord
, vol.28
, pp. 447-450
-
-
Miraglia del Giudice, E.1
Santoro, N.2
Cirillo, G.3
-
11
-
-
34547831224
-
The V103I polymorphism of the MC4R gene and obesity: Population based studies and meta-analysis of 29 563 individuals
-
Young EH, Wareham NJ, Farooqi S et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int J Obes (Lond) 2007;31:1437-1441.
-
(2007)
Int J Obes (Lond)
, vol.31
, pp. 1437-1441
-
-
Young, E.H.1
Wareham, N.J.2
Farooqi, S.3
-
12
-
-
20544465383
-
Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population
-
Chen Y, Snieder H, Wang X et al. Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population. Eur J Hum Genet 2005;13:772-780.
-
(2005)
Eur J Hum Genet
, vol.13
, pp. 772-780
-
-
Chen, Y.1
Snieder, H.2
Wang, X.3
-
13
-
-
23644457655
-
Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: A family study
-
Baker M, Gaukrodger N, Mayosi BM et al. Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Diabetes 2005;54:2492-2496.
-
(2005)
Diabetes
, vol.54
, pp. 2492-2496
-
-
Baker, M.1
Gaukrodger, N.2
Mayosi, B.M.3
-
14
-
-
2342609965
-
A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels
-
Hager J, Clement K, Francke S et al. A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels. Int J Obes Relat Metab Disord 1998;22:200-205.
-
(1998)
Int J Obes Relat Metab Disord
, vol.22
, pp. 200-205
-
-
Hager, J.1
Clement, K.2
Francke, S.3
-
15
-
-
0033668792
-
A polymorphic marker in the leptin gene associated with Japanese morbid obesity
-
Ohshiro Y, Ueda K, Nishi M et al. A polymorphic marker in the leptin gene associated with Japanese morbid obesity. J Mol Med 2000;78:516-520.
-
(2000)
J Mol Med
, vol.78
, pp. 516-520
-
-
Ohshiro, Y.1
Ueda, K.2
Nishi, M.3
-
16
-
-
15144353456
-
Exonic and intronic sequence variation in the human leptin receptor gene (LEPR)
-
Chung WK, Power-Kehoe L, Chua M et al. Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 1997;46:1509-1511.
-
(1997)
Diabetes
, vol.46
, pp. 1509-1511
-
-
Chung, W.K.1
Power-Kehoe, L.2
Chua, M.3
-
18
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjørbæk C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59:305-331.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 305-331
-
-
Bjørbæk, C.1
Kahn, B.B.2
-
19
-
-
31044451078
-
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
-
de Luca C, Kowalski TJ, Zhang Y et al. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 2005;115:3484-3493.
-
(2005)
J Clin Invest
, vol.115
, pp. 3484-3493
-
-
de Luca, C.1
Kowalski, T.J.2
Zhang, Y.3
-
20
-
-
0035145908
-
Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
-
Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 2001;50:425-435.
-
(2001)
Diabetes
, vol.50
, pp. 425-435
-
-
Kowalski, T.J.1
Liu, S.M.2
Leibel, R.L.3
Chua Jr., S.C.4
-
21
-
-
1442349754
-
Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice
-
Chua SC Jr, Liu SM, Li Q et al. Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Am J Physiol Endocrinol Metab 2004;286: E384-E392.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Chua Jr, S.C.1
Liu, S.M.2
Li, Q.3
-
22
-
-
0037456304
-
STAT3 signaling is required for leptin regulation of energy balance but not reproduction
-
Bates SH, Stearns WH, Schubert M et al. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 2003;421:856-859.
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Schubert, M.3
-
23
-
-
35648968069
-
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
-
Gong Y, Ishida-Takahashi R, Villanueva EC et al. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem 2007;282:31019-31027.
-
(2007)
J Biol Chem
, vol.282
, pp. 31019-31027
-
-
Gong, Y.1
Ishida-Takahashi, R.2
Villanueva, E.C.3
-
24
-
-
0029776030
-
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
-
Baumann H, Morella KK, White DW et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996;93:8374-8378.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8374-8378
-
-
Baumann, H.1
Morella, K.K.2
White, D.W.3
-
25
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563-14572.
-
(2000)
J Biol Chem
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
26
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
Bjørbaek C, Buchholz RM, Davis SM et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 2001;276:4747-4755.
-
(2001)
J Biol Chem
, vol.276
, pp. 4747-4755
-
-
Bjørbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
-
27
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjørbaek C, Lavery HJ, Bates SH et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 2000;275:40649-40657.
-
(2000)
J Biol Chem
, vol.275
, pp. 40649-40657
-
-
Bjørbaek, C.1
Lavery, H.J.2
Bates, S.H.3
-
28
-
-
34248227278
-
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
-
Björnholm M, Münzberg H, Leshan RL et al. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 2007;117:1354-1360.
-
(2007)
J Clin Invest
, vol.117
, pp. 1354-1360
-
-
Björnholm, M.1
Münzberg, H.2
Leshan, R.L.3
-
29
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T, Furukawa N et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
-
30
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH et al. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001;413:794-795.
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
-
31
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, Proulx K, Smith KA et al. Hypothalamic mTOR signaling regulates food intake. Science 2006;312:927-930.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
-
32
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
Xu AW, Kaelin CB, Takeda K et al. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 2005;115:951-958.
-
(2005)
J Clin Invest
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
-
33
-
-
33745819212
-
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
-
Plum L, Ma X, Hampel B et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest 2006;116:1886-1901.
-
(2006)
J Clin Invest
, vol.116
, pp. 1886-1901
-
-
Plum, L.1
Ma, X.2
Hampel, B.3
-
34
-
-
0031886385
-
Localization of leptin binding domain in the leptin receptor
-
Fong TM, Huang RR, Tota MR et al. Localization of leptin binding domain in the leptin receptor. Mol Pharmacol 1998;53:234-240.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 234-240
-
-
Fong, T.M.1
Huang, R.R.2
Tota, M.R.3
-
35
-
-
21044451449
-
Mapping of the interface between leptin and the leptin receptor CRH2 domain
-
Iserentant H, Peelman F, Defeau D et al. Mapping of the interface between leptin and the leptin receptor CRH2 domain. J Cell Sci 2005;118:2519-2527.
-
(2005)
J Cell Sci
, vol.118
, pp. 2519-2527
-
-
Iserentant, H.1
Peelman, F.2
Defeau, D.3
-
36
-
-
33744959239
-
Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex
-
Peelman F, Iserentant H, De Smet AS et al. Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex. J Biol Chem 2006;281:15496-15504.
-
(2006)
J Biol Chem
, vol.281
, pp. 15496-15504
-
-
Peelman, F.1
Iserentant, H.2
De Smet, A.S.3
-
37
-
-
0030611940
-
The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity
-
Silver K, Walston J, Chung WK et al. The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity. Diabetes 1997;46:1898-1900.
-
(1997)
Diabetes
, vol.46
, pp. 1898-1900
-
-
Silver, K.1
Walston, J.2
Chung, W.K.3
-
38
-
-
0035015030
-
LEPR gene polymorphisms: Associations with overweight, fat mass and response to diet in women
-
Mammès O, Aubert R, Betoulle D et al. LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. Eur J Clin Invest 2001;31:398-404.
-
(2001)
Eur J Clin Invest
, vol.31
, pp. 398-404
-
-
Mammès, O.1
Aubert, R.2
Betoulle, D.3
-
39
-
-
17344387584
-
Amino acid variants in the human leptin receptor: Lack of association to juvenile onset obesity
-
Echwald SM, Sørensen TD, Sørensen TI et al. Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity. Biochem Biophys Res Commun 1997;233:248-252.
-
(1997)
Biochem Biophys Res Commun
, vol.233
, pp. 248-252
-
-
Echwald, S.M.1
Sørensen, T.D.2
Sørensen, T.I.3
-
40
-
-
0034847530
-
The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability
-
Yiannakouris N, Yannakoulia M, Melistas L et al. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001;86:4434-4439.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4434-4439
-
-
Yiannakouris, N.1
Yannakoulia, M.2
Melistas, L.3
-
41
-
-
9844266242
-
Human leptin receptor gene in obese Japanese subjects: Evidence against either obesity-causing mutations or association of sequence variants with obesity
-
Matsuoka N, Ogawa Y, Hosoda K et al. Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 1997;40:1204-1210.
-
(1997)
Diabetologia
, vol.40
, pp. 1204-1210
-
-
Matsuoka, N.1
Ogawa, Y.2
Hosoda, K.3
-
42
-
-
0030915473
-
Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
-
Thompson DB, Ravussin E, Bennett PH, Bogardus C. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. Hum Mol Genet 1997;6:675-679.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 675-679
-
-
Thompson, D.B.1
Ravussin, E.2
Bennett, P.H.3
Bogardus, C.4
-
43
-
-
0030927064
-
Leptin receptor gene variation and obesity: Lack of association in a white British male population
-
Gotoda T, Manning BS, Goldstone AP et al. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 1997;6:869-876.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 869-876
-
-
Gotoda, T.1
Manning, B.S.2
Goldstone, A.P.3
-
44
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563-14572.
-
(2000)
J Biol Chem
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
45
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
Bjørbæk C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-32695.
-
(1997)
J Biol Chem
, vol.272
, pp. 32686-32695
-
-
Bjørbæk, C.1
Uotani, S.2
da Silva, B.3
Flier, J.S.4
-
46
-
-
0036828842
-
Regulation of Jak kinases by intracellular leptin receptor sequences
-
Kloek C, Haq AK, Dunn SL et al. Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 2002;277:41547- 41555.
-
(2002)
J Biol Chem
, vol.277
, pp. 41547-41555
-
-
Kloek, C.1
Haq, A.K.2
Dunn, S.L.3
-
47
-
-
18344396039
-
A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference
-
Heo M, Leibel RL, Fontaine KR et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int J Obes Relat Metab Disord 2002;26:640-646.
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 640-646
-
-
Heo, M.1
Leibel, R.L.2
Fontaine, K.R.3
-
48
-
-
0036219070
-
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
-
Bahrenberg G, Behrmann I, Barthel A et al. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol Endocrinol 2002;16:859-872.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 859-872
-
-
Bahrenberg, G.1
Behrmann, I.2
Barthel, A.3
-
49
-
-
0033556386
-
Characterization and binding specificity of the monomeric STAT3-SH2 domain
-
Haan S, Hemmann U, Hassiepen U et al. Characterization and binding specificity of the monomeric STAT3-SH2 domain. J Biol Chem 1999;274:1342-1348.
-
(1999)
J Biol Chem
, vol.274
, pp. 1342-1348
-
-
Haan, S.1
Hemmann, U.2
Hassiepen, U.3
-
50
-
-
11444250092
-
Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
-
Hekerman P, Zeidler J, Bamberg-Lemper S et al. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 2005;272:109-119.
-
(2005)
FEBS J
, vol.272
, pp. 109-119
-
-
Hekerman, P.1
Zeidler, J.2
Bamberg-Lemper, S.3
-
51
-
-
34248227278
-
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
-
Björnholm M, Münzberg H, Leshan RL et al. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 2007;117:1354-1360.
-
(2007)
J Clin Invest
, vol.117
, pp. 1354-1360
-
-
Björnholm, M.1
Münzberg, H.2
Leshan, R.L.3
-
52
-
-
4644358139
-
Mapping of the leptin binding sites and design of a leptin antagonist
-
Peelman F, Van Beneden K, Zabeau L et al. Mapping of the leptin binding sites and design of a leptin antagonist. J Biol Chem 2004;279:41038-41046.
-
(2004)
J Biol Chem
, vol.279
, pp. 41038-41046
-
-
Peelman, F.1
Van Beneden, K.2
Zabeau, L.3
-
53
-
-
20744460050
-
Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
-
Zabeau L, Defeau D, Iserentant H et al. Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains. J Biol Chem 2005;280:22632-22640.
-
(2005)
J Biol Chem
, vol.280
, pp. 22632-22640
-
-
Zabeau, L.1
Defeau, D.2
Iserentant, H.3
-
54
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
Chua SC Jr, Chung WK, Wu-Peng XS et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-996.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua Jr, S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
-
55
-
-
0030928574
-
Constitutive and impaired signaling of leptin receptors containing the Gln -> Pro extracellular domain fatty mutation
-
White DW, Wang DW, Chua SC Jr et al. Constitutive and impaired signaling of leptin receptors containing the Gln -> Pro extracellular domain fatty mutation. Proc Natl Acad Sci USA 1997;94:10657-10662.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10657-10662
-
-
White, D.W.1
Wang, D.W.2
Chua Jr, S.C.3
-
56
-
-
0026783555
-
The influence of genetic background on the expression of mutations at the diabetes (db) locus in the mouse. VI: Hepatic malic enzyme activity is associated with diabetes severity
-
Coleman DL. The influence of genetic background on the expression of mutations at the diabetes (db) locus in the mouse. VI: Hepatic malic enzyme activity is associated with diabetes severity. Metabolism 1992;41:1134-1136.
-
(1992)
Metabolism
, vol.41
, pp. 1134-1136
-
-
Coleman, D.L.1
-
57
-
-
36849038409
-
TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: Analysis of 3,501 individuals
-
Guo T, Hanson RL, Traurig M et al. TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals. Diabetes 2007;56:3082-3088.
-
(2007)
Diabetes
, vol.56
, pp. 3082-3088
-
-
Guo, T.1
Hanson, R.L.2
Traurig, M.3
-
58
-
-
17744381149
-
Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
-
Chagnon YC, Wilmore JH, Borecki IB et al. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 2000;85:29-34.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 29-34
-
-
Chagnon, Y.C.1
Wilmore, J.H.2
Borecki, I.B.3
-
59
-
-
0035073893
-
A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
-
Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 2001;108:233-236.
-
(2001)
Hum Genet
, vol.108
, pp. 233-236
-
-
Quinton, N.D.1
Lee, A.J.2
Ross, R.J.3
Eastell, R.4
Blakemore, A.I.5
-
60
-
-
18644375929
-
Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents
-
Guizar-Mendoza JM, Amador-Licona N, Flores-Martinez SE et al. Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. J Hum Hypertens 2005;19:341-346.
-
(2005)
J Hum Hypertens
, vol.19
, pp. 341-346
-
-
Guizar-Mendoza, J.M.1
Amador-Licona, N.2
Flores-Martinez, S.E.3
-
61
-
-
34249666244
-
Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
-
Fairbrother UL, Tanko LB, Walley AJ et al. Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. J Bone Miner Res 2007;22:544-550.
-
(2007)
J Bone Miner Res
, vol.22
, pp. 544-550
-
-
Fairbrother, U.L.1
Tanko, L.B.2
Walley, A.J.3
-
62
-
-
0033021670
-
Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study
-
Chagnon YC, Chung WK, Perusse L et al. Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study. Int J Obes Relat Metab Disord 1999;23:278-286.
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
, pp. 278-286
-
-
Chagnon, Y.C.1
Chung, W.K.2
Perusse, L.3
-
63
-
-
0032788234
-
Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males
-
de Silva AM, Walder KR, Aitman TJ et al. Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males. Int J Obes Relat Metab Disord 1999;23:816-822.
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
, pp. 816-822
-
-
de Silva, A.M.1
Walder, K.R.2
Aitman, T.J.3
-
64
-
-
0036954311
-
The Gln223Arg polymorphism of the leptin receptor in Pima Indians: Influence on energy expenditure, physical activity and lipid metabolism
-
Stefan N, Vozarova B, Del Parigi A et al. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int J Obes Relat Metab Disord 2002;26:1629-1632.
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 1629-1632
-
-
Stefan, N.1
Vozarova, B.2
Del Parigi, A.3
-
65
-
-
3042579670
-
Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
-
Ogawa T, Hirose H, Yamamoto Y et al. Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism 2004;53:879-885.
-
(2004)
Metabolism
, vol.53
, pp. 879-885
-
-
Ogawa, T.1
Hirose, H.2
Yamamoto, Y.3
-
66
-
-
33744470566
-
The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia
-
van der Vleuten GM, Kluijtmans LA, Hijmans A et al. The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia. Int J Obes (Lond) 2006;30:892-898.
-
(2006)
Int J Obes (Lond)
, vol.30
, pp. 892-898
-
-
van der Vleuten, G.M.1
Kluijtmans, L.A.2
Hijmans, A.3
-
67
-
-
33748194234
-
G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines
-
Wang TN, Huang MC, Chang WT et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring) 2006;14:183-187.
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 183-187
-
-
Wang, T.N.1
Huang, M.C.2
Chang, W.T.3
-
68
-
-
33947581477
-
-
Mergen H, Karaaslan C, Mergen M, Deniz Ozsoy E, Ozata M. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Endocr J 2007;54:89-94.
-
Mergen H, Karaaslan C, Mergen M, Deniz Ozsoy E, Ozata M. LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity. Endocr J 2007;54:89-94.
-
-
-
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