LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity

Endocrine Journal

Volumn 54, Issue 1, 2007, Pages 89-94

  Mergen, Hatice ^a   Karaaslan, Çaǧatay ^a   Mergen, Mehmet ^b   Deniz Özsoy, Ergi ^a   Özata, Metin ^c  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Ankara Mevkii Military Hospital   (Turkey)

^c GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

Author keywords

B3 adrenergic receptor; Insulin receptor substrate 1; Leptin receptor; Obesity; PCR; Polymorphism; RFLP; Serotonin transporter

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN RECEPTOR; SEROTONIN TRANSPORTER;

ARTICLE; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYMERASE CHAIN REACTION; PREVALENCE;

BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; OBESITY; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-3; RECEPTORS, CELL SURFACE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33947581477     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K06-023     Document Type: Article

References (29)

1. Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB (1999) Annual deaths attributable to obesity in the United States. JAMA 282: 1530-1538.
2. Rosmond R (2003) Association studies of genetic polymorphisms in central obesity: a critical review. Int J Obes Relat Metab Disord 27: 1141-1151.
3. 3- adrenergic receptor gene in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes 109: 386-388.
4. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N, Sorkin JD, Roth J, Shuldiner AR (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic receptor gene. N Engl J Med 333: 343-347.
5. Clement K, Vaisse C, Manning BS, et al. (1995) Genetic variation in the beta(3)-adrenergic-receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 333: 352-354.
6. Widen E, Lehto M, Kanninen T, Walston J, Schuldiner A, Groop LC (1995) Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 333: 348-351.
7. Kadowaki H, Yasuda K, Iwamoto K, Otabe S, Shimokawa K, Silver K, Watson J, Yoshinaga H, Kosaka K, Yamada N (1995) A mutation in the beta(3)-adrenergic- receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 215: 555-560.
8. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
9. Chagnon YC, Wilmore JH, Borecki IB, Gagnon J, Perusse L, Chagnon M, Collier GR, Leon AS, Skinner JS, Rao DC, Bouchard C (2000) Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 85: 29-34.
10. Quinton ND, Lee AJ, Ross RJ, Eastell R, Blakemore AI (2001) A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet 108: 233-236.
11. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS (2001) The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 86: 4434-4439.
12. Rudnick G, Clark J (1993) From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta 1144: 249-263.
13. Bellivier F, Szoke A, Henry C, Lacoste J, Bottos C, Nosten-Bertrand M, Hardy P, Rouillon F, Launay JM, Laplanche JL, Leboyer M (2000) Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry 48: 319-322.
14. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, Riederer P, Lesch KP (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 102: 247-254.
15. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624.
16. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Muller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP (1996) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1: 453-460.
17. Fumeron F, Betoulle D, Aubert R, Herbeth B, Siest G, Rigaud D (2001) Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake. Mol Psychiatry 6: 9-10.
18. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K, Pirke KM, Heils A, Rosenkranz K, Roth H, Coners H, Mayer H, Herzog W, Siegfried A, Lehmkuhl G, Poustka F, Schmidt MH, Schafer H, Grzeschik KH, Lesch KP, Lentes KU, Remschmidt H, Hebebrand J (1997) Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa. Life Sci 61: 295-303.
19. Di Bella DD, Catalano M, Cavallini MC, Riboldi C, Bellodi L (2000) Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. Mol Psychiatry 5: 233-234.
20. Sundaramurthy D, Pieri LF, Gape H, Markham AF, Campbell DA (2000) Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa. Am J Med Genet 96: 53-55.
21. White MF (1997) The insulin signalling system and the IRS proteins. Diabetologia 40: 2-17.
22. Clausen JO, Hansen T, Bjorbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Winther K, et al. (1995) Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 346 : 397-402.
23. Matsuoka N, Ogawa Y, Hosoda K, Matsuda J, Masuzaki H, Miyawaki T, Azuma N, Natsui K, Nishimura H, Yoshimasa Y, Nishi S, Thompson DB, Nakao K (1997) Human leptin receptor gene in obese Japanese subjects: evidence against either obesity causing mutations or association of sequence variants with obesity. Diabetologia 40: 1204-1210.
24. Baroni MG, D'Andrea MP, Montali A, Pannitteri G, Barilla F, Campagna F, Mazzei E, Lovari S, Seccareccia F, Campa PP, Ricci G, Pozzilli P, Urbinati G, Arca M (1999) A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol 19: 2975-2980.
25. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 29; 274: 1527-1531.
26. Sokal RR, Rohlf FJ (1995) Biometry: the principles and practice of statistics in biological research. 3rd. Edition. W.H. Freeman and Co., New York, p. 887.
27. Workman PL, Niswander JD (1970) Population studies on southwestern Indian tribes. II. Local genetic differentiation in the Papago. Am J Hum Genet 22: 24-49.
28. Gagnon J, Mauriege P, Roy S, Sjostrome D, Chagnon YC, Dionne FT, Oppert JM, Perrusse L, Sjostrom L, Bouchard C (1996) The Trp64Arg mutation of the beta 3 adrenergic receptor gene has no effect on obesity phenotypes in the Quebec family study and Swedish obese subjects cohorts. J Clin Invest 98: 2086-2093.
29. Silver K, Walston J, Chung WK, Yao F, Parikh VV, Andersen R, Cheskin LJ, Elahi D, Muller D, Leibel RL, Shuldiner AR (1997) The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity. Diabetes 46: 1898-1900.