An integrated decision-tree testing strategy for skin sensitisation with respect to the requirements of the EU REACH legislation

Alternatives to Laboratory Animals

Volumn 36, Issue SUPPL. 1, 2008, Pages 75-89

  Grindon, Christina ^a   Combes, Robert ^a   Cronin, Mark T D ^b   Roberts, David W ^b   Garrod, John F ^c  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c DEFRA   (United Kingdom)

Author keywords

Animal testing; Decision trees; Defra; In silico models; In vitro testing; Integrated testing strategies; REACH; Risk assessment; Skin sensitisation; Three Rs.

Indexed keywords

ALLERGEN;

ANIMAL TESTING ALTERNATIVE; IN VITRO STUDY; NONHUMAN; NOTE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SKIN SENSITIZATION; SKIN TOXICITY; T LYMPHOCYTE ACTIVATION; TOXICITY TESTING;

ANIMALIA; CAVIA;

EID: 57349111810     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290803601s07     Document Type: Note

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106. Patlewicz, G., Basketter, D.A., Smith, C.K., Hotchkiss, S.A.M. & Roberts, D.W. (2001). Skin-sensitization structure-activity relationships for aldehydes. Contact Dermatitis 44, 331-336.
107. Roberts, D.W., Aptula, A.O. & Patlewicz, G. (2006). Mechanistic applicability domains for non-animal based prediction of toxicological endpoints. QSAR analysis of the Schiff-base applicability domain for skin sensitization. Chemical Research in Toxicology 19, 1228-1233.
108. Roberts, D.W. & Patlewicz, G. (2002). Mechanism based structure-activity relationships for skin sensitisation - the carbonyl group domain. SAR & QSAR in Environmental Research 13, 145-152.
109. Roberts, D.W. & Benezra, C. (1993). Quantitiative structure-activity relationships for skin sensitization potential of urushiol analogues. Contact Dermatitis 29, 78-83.
110. Basketter, D.A., Roberts, D.W., Cronin, M. & Scholes, E.W. (1992). The value of the local lymph node assay in quantitative structure-activity investigations. Contact Dermatitis 27, 137-142.
111. Hatch, K.L. & Magee, P.S. (1998). A discriminant model for allergic contact dermatitis in anthraquinone disperse dyes. Quantitative Structure-Activity Relationships 17, 20-26.
112. Barratt, M.D., Basketter, D.A. & Roberts, D.W. (1994). Skin sensitization structure-activity relationships for phenyl benzoates. Toxicology in Vitro 8, 823-826.
113. Hostýnek, J.J. & Magee, P.S. (1997). Fragrance allergens: Classification and ranking by QSAR. Toxicology in Vitro 11, 377-384.
114. Franot, C., Roberts, D.W., Basketter, D.A., Benezra, C. & Lepoittevin, J.P. (1994). Structure-activity relationships for contact allergenic potential of α,α- dimethyl-γ-butyrolactone derivatives. 2. Quantitative structure skin sensitization relationships for α-substituted-α-methyl-α,α-dimethyl-γ- butyrolactone. Chemical Research in Toxicology 7, 307-312.