Further evaluation of the quantitative structure-activity relationship for skin-sensitizing alkyl transfer agents

Contact Dermatitis

Volumn 37, Issue 3, 1997, Pages 107-112

  Roberts, D W ^a   Basketter, D A ^a  

^a UNILEVER RESEARCH   (United Kingdom)

Author keywords

Alkyl alkane sulfonates; Alkyl transfer agents; Cross sensitivity; Guinea pig sensitization; Modified single adjuvant test; MSIAT; QSAR; Quantitative structure activity relationship

Indexed keywords

ALKANESULFONIC ACID; ALKYL GROUP;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; EPIDERMIS; ETIOLOGY; GUINEA PIG; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SKIN SENSITIZATION; STRATUM CORNEUM; STRUCTURE ACTIVITY RELATION;

ALKANESULFONATES; ANIMALS; BROMIDES; DERMATITIS, ALLERGIC CONTACT; DRUG EVALUATION; ESTERS; GUINEA PIGS; SKIN; SKIN TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030808938     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1997.tb00313.x     Document Type: Article

References (12)

1. Basketter D A, Dooms-Goossens A, Karlberg A-T and Lepoittevin J-P. The chemistry of contact allergy: Why is a molecule allergenic? Contact Dermatitis 1995: 32: 65-73.
2. Barratt M D, Basketter D A, Chamberlain M, Admans G and Langowski J. An expert system rulebase for identifying contact allergens. Toxicol in Vitro 1994: 8: 1053-1060.
3. Roberts D W, Williams D L. The derivation of quantitative correlations between skin sensitisation and physicochemical parameters for alkylating agents, and their application to experimental data for sultones. J Theor Biol 1982: 99: 807-825.
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5. Roberts D W. Structure activity relationships for skin sensitization potential of diacrylates and dimethylacrylates. Contact Dermatitis 1987: 17: 281-289.
6. Roberts D W, Goodwin B F J, Basketter D A. Methyl groups as antigenic determinants in skin sensitisation. Contact Dermatitis 1988: 18: 219-225.
7. Basketter D A, Roberts D W, Cronin M, Scholes E W. The value of the local lymph node assay in quantitative structure activity investigations. Contact Dermatitis 1992: 27: 137-142.
8. Leo A J, Hansch C. Substituent Constants for Correlation Analysis in Chemistry and Biology. New York: Wiley, 1979.
9. Roberts D W, Ward R S, Hughes P J. Relative reactivities in aminolysis reactions of alkyl alkanesulphonates. J Chem Res 1995: XX: 70-71.
10. Barratt M D. Quantitative structure activity relationships for skin permeability. Toxicology in Vitro 1995: 9: 27-37.
11. Franot C, Roberts D W, Basketter D A, Benezra C, Lepoittevin J-P. Structure activity relationships for contact allergenic potential of γ, γ-dimethyl-γ butyrolactone derivatives (2). Quantitative structure-skin sensitization relationships for α-substituted α-methyl-γ, γ-dimethyl-γ-butyrolactones. Chem Res Toxicol 1994: 7: 307-312.
12. P. Barton et al. J. Pharm. Sci., submitted.