Recent advances in the research of HIV-1 RNase H inhibitors

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 12, 2008, Pages 1243-1251

  Yu, Fang ^a   Liu, Xinyong ^a   Zhan, Peng ^a   De Clercq, Erik ^b  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

AIDS; HIV 1; Mechanism; RNase H inhibitor; SAR

Indexed keywords

1,4 NAPHTHOQUINONE; 4 CHLOROPHENYLHYDRAZONE MESOXALIC ACID; ACETYLSHIKONIN; ARDISIA JAPONICA EXTRACT; DNA; DNA DIRECTED DNA POLYMERASE; DNA FRAGMENT; ESTERASE INHIBITOR; HETERODUPLEX; ILLIMAQUINONE; IMIDE; JUGLONE; MANICOL; MENADIONE; N (4 TERT BUTYLBENZOYL) 2 HYDROXY 1 NAPHTHALDEHYDE HYDRAZONE; NAPHTHALENESULFONIC ACID DERIVATIVE; NAPHTHAZARIN; PLANT EXTRACT; PLUMBAGIN; RIBONUCLEASE H; RIBONUCLEASE INHIBITOR; RNA; RNA DIRECTED DNA POLYMERASE; SHIKONIN; SHIKONIN DERIVATIVE; THUJAPLICIN; TROPOLONE; TROPOLONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE 5' PHOSPHATE;

ANTIVIRAL ACTIVITY; ARDISIA; ARDISIA JAPONICA; DNA DEGRADATION; DRUG DESIGN; DRUG MECHANISM; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MEDICAL LITERATURE; PROTEIN FUNCTION; REVERSE TRANSCRIPTION; REVIEW; RNA DEGRADATION; STRUCTURE ACTIVITY RELATION; VIROGENESIS;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HIV INFECTIONS; HIV-1; HUMANS; IONS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RIBONUCLEASE H; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57149142659     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708786141052     Document Type: Review

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