A novel mechanism for inhibition of HIV-1 reverse transcriptase

Bioorganic Chemistry

Volumn 30, Issue 6, 2002, Pages 443-458

  Skillman, A Geoffrey ^a,f   Maurer, Karl W ^a,g   Roe, Diana C ^a,h   Stauber, Margaret J ^a,i   Eargle, Dolan ^a   Ewing, Todd J A ^a,j   Muscate, Angelika ^a   Davioud Charvet, Elisabeth ^b   Medaglia, Maxine V ^c   Fisher, Robert J ^c   Arnold, Edward ^d   Gao, Hong Qiang ^c   Buckheit, Robert ^e   Boyer, Paul L ^c   Hughes, Stephen H ^c   Kuntz, Irwin D ^a   Kenyon, George L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e SOUTHERN RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g University of California ^*  (United States)

^h SANDIA NATIONAL LABORATORIES   (United States)

ⁱ Gillette Research Institute   (United States)

^j Camitro Inc   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

2 NAPHTHALENESULFONIC ACID 4 HYDROXY 7 [[[[5 HYDROXY 6 [(4 CINNAMYLPHENYL)AZO] 7 SULFO 2 NAPHTHALENYL]AMINO]CARBONYL]AMINO] 3 [(4 CINNAMYLPHENYL)AZO]DISODIUM; DNA POLYMERASE; NUCLEOSIDE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CYTOTOXICITY; DNA BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME BINDING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; INHIBITION KINETICS; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ANALYSIS; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE; MURINE LEUKEMIA VIRUS;

EID: 0036910799     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-2068(02)00502-3     Document Type: Article

References (42)

1. Palella F., Delaney K., Moorman A., Loveless M., Fuhrer J., Satten G., Aschman D., Holmberg S. N. Engl. J. Med. 338:1998;853-860.
2. Piot P. Science. 280:1998;1844-1845.
3. Carpenter C., Fischl M., Hammer S., Hirsch M., Jacobsen D., Katzenstein D., Montaner J., Richman D., Saag M., Schooley R., Thompson M., Vella S., Yeni P., Volberding P. J. Am. Med. Assoc. 280:1998;78-86.
4. Wong J.K., Hezareh M., Gunthard H.F., Havlir D.V., Ignacio C.C., Spina C.A., Richman D.D. Science. 278:1997;1291-1295.
5. Telesnitsky A., Goff S. Coffin J., Hughes S., Varmus H. Retroviruses. 1997;141-146 Cold Spring Harbor Laboratory Press, Plainview, New York.
6. Hecht F., Grant R., Petropoulos C., Dillon B., Chesney M., Tian H., Hellmann N., Bandrapalli N., Digilio L., Branson B., Kahn J. N. Engl. J. Med. 339:1998;307-311.
7. Declercq E. Aids Res. Human Retroviruses. 8:1992;119-137.
8. Emini E., Fan H. Coffin J., Hughes S., Varmus H. Retroviruses. 1997;666-667 Cold Spring Harbor Laboratory Press, Plainview, New York.
9. Huang H., Chopra R., Verdine G., Harrison S. Science. 282:1998;1669-1675.
10. Tan G., Wickramasinghe A., Verma S., Singh R., Hughes S., Pezzuto J., Baba M., Mohan P. J. Med. Chem. 35:1992;4846-4853.
11. Mohan P., Loya S., Avidan O., Verma S., Dhindsa G., Wong M., Huang P., Yashiro M., Baba M., Hizi A. J. Med. Chem. 37:1994;2513-2519.
12. Moelling K., Schulze T., Diringer H. J. Virol. 63:1989;5489-5491.
13. Sun H., Qiu S., Lin L., Wang Z., Lin Z., Pengsuparp T., Pezzuto J., Fong H., Cordell G., Farnsworth N. J. Nat. Prod. 59:1996;525-527.
14. Loya S., Rudi A., Kashman Y., Hizi A. Biochem. J. 324:1997;721-727.
15. Loya S., Bakhanashvili M., Kashman Y., Hizi A. Biochemistry. 34:1995;2260-2266.
16. Ohta K., Mizushina Y., Hirata N., Takemura M., Sugawara F., Matsukage A., Yoshida S., Sakaguchi K. Chem. Pharm. Bull. Tokyo. 46:1998;684-686.
17. Loya S., Bakhanashvili M., Kashman Y., Hizi A. Arch. Biochem. Biophys. 316:1995;789-796.
18. Meng E., Shoichet B., Kuntz I. J. Comput. Chem. 13:1992;505-524.
19. Meng E., Gschwend D., Blaney J., Kuntz I. Protein-Struct. Funct. Genet. 17:1993;266-278.
20. Kuntz I., Blaney J., Oatley S., Langridge R., Ferrin T. J. Mol. Biol. 161:1982;269-288.
21. Ewing T., Kuntz I. J. Comput. Chem. 18:1997;1175-1189.
22. Connolly M.L. Science. 221:1983;709-713.
23. Jacobo-Molina A., Ding J., Nanni R., Clark A., Lu X., Tantillo C., Williams R., Kamer G., Ferris A., Clark P., Hizi A., Hughes S., Arnold E. Proc. Natl. Acad. Sci. USA. 90:1993;6320-6324.
24. Rusinko A., Sheridan R., Nilakatan R., Haraki K., Bauman N., Venkataghavan R. J. Chem. Inform. Comput. Sci. 29:1989;251-255.
25. Gasteiger J., Marsili M. Tetrahedron Lett. 36:1980;3219.
26. Weiner S., Kollman P., Case D., Singh U., Ghio C., Alagona G., Profeta S. Jr., Weiner P. J. Am. Chem. Soc. 106:1984;765-784.
27. Bemis G., Kuntz I. J. Comput. Aid. Molec. Design. 6:1992;607-628.
28. Maurer K., Tang A.H., Kenyon G.L., Leavitt A.D. Bioorganic Chemistry. 28:2000;140-155.
29. Thor, Merlin, and Daylight Toolkits, version 4.51, Daylight Chemical Information Systems, Inc., Santa Fe, NM.
30. Willett P. Similarity and Clustering in Chemical Information Systems. 1987;Wiley, New York, NY.
31. A. Skillman, Chapter 2: "UC Select, Development and Implementation of A Common Nomenclature Method to Search Chemical Databases", Ph.D. thesis, University of California, San Francisco, CA.
32. RT SPA Enzyme Assay Kit NK8972, Amershan Life Science, Inc., Arlington Heights, IL 60005.
33. Boyer P., Ferris A., Hughes S. J. Virol. 66:1992;7533-7537.
34. Boyer P., Ferris A., Hughes S. J. Virol. 66:1992;1031-1039.
35. Boyer P., Tantillo C., Jacobo-Molina A., Nanni R., Ding J., Arnold E., Hughes S. Proc. Natl. Acad. Sci. USA. 91:1994;4882-4886.
36. Fisher R., Fivash M., Casasfinet J., Erickson J., Kondoh A., Bladen S., Fisher C., Watson D., Papas T. Prot. Sci. 3:1994;257-266.
37. Christensen L. Anal. Biochem. 249:1997;153-164.
38. Loya S., Gao H., Avidan O., Boyer P., Hughes S., Hizi A. J. Virol. 71:1997;5668-5672.
39. Gao H., Boyer P., Arnold E., Hughes S. J. Mol. Biol. 277:1998;559-572.
40. Weislow O., Kiser R., Fine D., Bader J., Showmaker R., Boyd M. J. Natl. Cancer Inst. 81:1989;577-586.
41. Palaniappan C., Fay F., Bambara R. J. Biol. Chem. 270:1995;4861-4869.
42. Baba M., Schols D., Mohan P., DeClercq E., Shigeta S. Antivir. Chem. Chemother. 4:1993;229-234.