NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins

Neuropeptides

Volumn 42, Issue 5-6, 2008, Pages 601-609

  Xiao, Cai ^a   Huang, Yuanyuan ^a   Dong, Mingxin ^a   Hu, Jie ^a   Hou, Shuangshuang ^a   Castellino, Francis J ^b   Prorok, Mary ^b   Dai, Qiuyun ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Antinociception; Conantokins; NMDA receptor; Nociception; NR2B subunit; Pain

Indexed keywords

ACETIC ACID; CONANTOKIN G; CONANTOKIN R; CONANTOKIN T; FORMALDEHYDE; FREUND ADJUVANT; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HOT PLATE TEST; INFLAMMATION; MALE; MOTOR PERFORMANCE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CONOTOXINS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; INFLAMMATION; MALE; MICE; MOLECULAR SEQUENCE DATA; MOLLUSK VENOMS; MOTOR ACTIVITY; PAIN MEASUREMENT; PEPTIDES; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; ROTAROD PERFORMANCE TEST;

MUS;

EID: 56349135882     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2008.09.003     Document Type: Article

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