메뉴 건너뛰기




Volumn 77, Issue 3, 2001, Pages 812-822

Amino acid determinants for NMDA receptor inhibition by conantokin-T

Author keywords

3H MK 801; Conantokin analogs; Conantokins; Helicity; NMDA receptor

Indexed keywords

4 CARBOXYGLUTAMIC ACID; AMINO ACID; CONANTOKIN T; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0034999419     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00281.x     Document Type: Article
Times cited : (25)

References (45)
  • 1
    • 0030977984 scopus 로고    scopus 로고
    • Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: Cyclic lactams of the receptor binding region
    • Barbier J. R., Neugebauer W., Morley P., Ross V., Soska M., Whitfield J. F. and Willick G. (1997) Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: cyclic lactams of the receptor binding region. J. Med. Chem 40, 1373-1380.
    • (1997) J. Med. Chem , vol.40 , pp. 1373-1380
    • Barbier, J.R.1    Neugebauer, W.2    Morley, P.3    Ross, V.4    Soska, M.5    Whitfield, J.F.6    Willick, G.7
  • 2
    • 0027166069 scopus 로고
    • N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons
    • Benke T. A., Jones O. T., Collingridge G. L. and Angelides K. J. (1993) N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons. Proc. Natl. Acad. Sci. USA. 90, 7819-7823.
    • (1993) Proc. Natl. Acad. Sci. USA. , vol.90 , pp. 7819-7823
    • Benke, T.A.1    Jones, O.T.2    Collingridge, G.L.3    Angelides, K.J.4
  • 3
    • 0032544749 scopus 로고    scopus 로고
    • NMDA-receptor antagonist requirements in conantokin-G
    • Blandl T., Prorok M. and Castellino F. J. (1998) NMDA-receptor antagonist requirements in conantokin-G. FEBS Lett. 435, 257-262.
    • (1998) FEBS Lett. , vol.435 , pp. 257-262
    • Blandl, T.1    Prorok, M.2    Castellino, F.J.3
  • 4
    • 0003867690 scopus 로고    scopus 로고
    • Binding of cations to individual γ-carboxyglutamate residues of conantokin-G and conantokin-T
    • Blandl T., Warder S. E., Prorok M. and Castellino F. J. (1999) Binding of cations to individual γ-carboxyglutamate residues of conantokin-G and conantokin-T. J. Peptide Res. 53, 453-464.
    • (1999) J. Peptide Res. , vol.53 , pp. 453-464
    • Blandl, T.1    Warder, S.E.2    Prorok, M.3    Castellino, F.J.4
  • 5
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss T. V. and Collingridge G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 6
    • 0027280028 scopus 로고
    • Polyamine-like actions of peptides derived from conantokin G, an N-methyl-D-aspartate (NMDA) antagonist
    • Chandler P., Pennington M., Maccecchini M. L., Nashed N. T. and Skolnick P. (1993) Polyamine-like actions of peptides derived from conantokin G, an N-methyl-D-aspartate (NMDA) antagonist. J. Biol. Chem. 268, 171738.
    • (1993) J. Biol. Chem. , vol.268 , pp. 171738
    • Chandler, P.1    Pennington, M.2    Maccecchini, M.L.3    Nashed, N.T.4    Skolnick, P.5
  • 7
    • 0030437252 scopus 로고    scopus 로고
    • The effect of N-methylation on helical peptides
    • Chang C.-F. and Zehfus M. H. (1996) The effect of N-methylation on helical peptides. Biopolymers 40, 609-616.
    • (1996) Biopolymers , vol.40 , pp. 609-616
    • Chang, C.-F.1    Zehfus, M.H.2
  • 8
    • 0032568831 scopus 로고    scopus 로고
    • Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis
    • Chen Z. G., Blandl T., Prorok M., Warder S. E., Li L. P., Zhu Y., Pedersen L. G., Ni F. and Castellino F. J. (1998) Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis. J. Biol. Chem. 273, 16248-16258.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16248-16258
    • Chen, Z.G.1    Blandl, T.2    Prorok, M.3    Warder, S.E.4    Li, L.P.5    Zhu, Y.6    Pedersen, L.G.7    Ni, F.8    Castellino, F.J.9
  • 9
    • 0015522150 scopus 로고
    • Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion
    • Chen Y.-H., Yang J. T. and Martinez H. M. (1972) Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion. Biochemistry 11, 4120-4131.
    • (1972) Biochemistry , vol.11 , pp. 4120-4131
    • Chen, Y.-H.1    Yang, J.T.2    Martinez, H.M.3
  • 10
    • 0027174502 scopus 로고
    • Binding of calcium to synthetic peptides containing gamma-carboxyglutamic acid
    • Colpitts T. L. and Castellino F. J. (1993) Binding of calcium to synthetic peptides containing gamma-carboxyglutamic acid. Int. J. Peptide Protein Res. 41, 567-575.
    • (1993) Int. J. Peptide Protein Res. , vol.41 , pp. 567-575
    • Colpitts, T.L.1    Castellino, F.J.2
  • 11
    • 0026596320 scopus 로고
    • Anticonvulsant activity of competitive antagonists of NMDA receptor in genetically epilepsy-prone rats
    • De Sarro G. and De Sarro A. (1992) Anticonvulsant activity of competitive antagonists of NMDA receptor in genetically epilepsy-prone rats. Eur. J. Pharmacol. 215, 221-229.
    • (1992) Eur. J. Pharmacol. , vol.215 , pp. 221-229
    • De Sarro, G.1    De Sarro, A.2
  • 12
    • 0029085982 scopus 로고
    • Excitatory amino acid receptors and neurodegeneration
    • Doble A., (1995) Excitatory amino acid receptors and neurodegeneration. Therapie 50, 319-337.
    • (1995) Therapie , vol.50 , pp. 319-337
    • Doble, A.1
  • 13
    • 0033851790 scopus 로고    scopus 로고
    • Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors
    • Donevan S. D. and McCabe R. T. (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol. Pharmacol. 58, 614-623.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 614-623
    • Donevan, S.D.1    McCabe, R.T.2
  • 14
    • 0027340019 scopus 로고
    • Cultured hippocampal neurons from trisomy 16 mouse, a model for down's syndrome, have an abnormal action potential due to a reduced inward sodium current
    • Galdzicki Z., Coan E. and Rapoport S. I. (1993) Cultured hippocampal neurons from trisomy 16 mouse, a model for Down's syndrome, have an abnormal action potential due to a reduced inward sodium current. Brain Res. 604, 69-78.
    • (1993) Brain Res. , vol.604 , pp. 69-78
    • Galdzicki, Z.1    Coan, E.2    Rapoport, S.I.3
  • 15
    • 0025241893 scopus 로고
    • Conantokin-T. A γ-carboxyglutamate-containing peptide with N-methyl-D-aspartate antagonist activity
    • Haack J. A., Rivier J., Parks T. N., Mena E. E., Cruz L. J. and Olivera B. M. (1990) Conantokin-T. A γ-carboxyglutamate-containing peptide with N-methyl-D-aspartate antagonist activity. J. Biol. Chem. 265, 6025-6029.
    • (1990) J. Biol. Chem. , vol.265 , pp. 6025-6029
    • Haack, J.A.1    Rivier, J.2    Parks, T.N.3    Mena, E.E.4    Cruz, L.J.5    Olivera, B.M.6
  • 16
    • 0027372113 scopus 로고
    • Conantokin-G antagonism of the NMDA receptor subtype expressed in cultured cerebellar granule cells
    • Haack J. A., Parks T. N. and Olivera B. M. (1993) Conantokin-G antagonism of the NMDA receptor subtype expressed in cultured cerebellar granule cells. Neurosci. Lett. 163, 63-66.
    • (1993) Neurosci. Lett. , vol.163 , pp. 63-66
    • Haack, J.A.1    Parks, T.N.2    Olivera, B.M.3
  • 17
    • 0026735813 scopus 로고
    • Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA
    • Hammerland L. G., Olivera B. M. and Yoshikami D. (1992) Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA. Eur. J. Pharmacol. 226, 239-244.
    • (1992) Eur. J. Pharmacol. , vol.226 , pp. 239-244
    • Hammerland, L.G.1    Olivera, B.M.2    Yoshikami, D.3
  • 18
    • 0033578892 scopus 로고    scopus 로고
    • Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
    • Hawkins L. M., Chazot P. L. and Stephenson F. A. (1999) Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. J. Biol. Chem. 274, 27211-27218.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27211-27218
    • Hawkins, L.M.1    Chazot, P.L.2    Stephenson, F.A.3
  • 19
    • 0031588558 scopus 로고    scopus 로고
    • Developmental expression, subcellular localization, and tyrosine phosphorylation of NR2A and NR2B in the rat brain
    • Jin D. H., Jung Y. W., Ham S. H., Ko B. H. and Moon I. S. (1997a) Developmental expression, subcellular localization, and tyrosine phosphorylation of NR2A and NR2B in the rat brain. Mol. Cells 7, 64-71.
    • (1997) Mol. Cells , vol.7 , pp. 64-71
    • Jin, D.H.1    Jung, Y.W.2    Ham, S.H.3    Ko, B.H.4    Moon, I.S.5
  • 20
    • 0031592969 scopus 로고    scopus 로고
    • Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain
    • Jin D. H., Jung Y. W., Ko B. H. and Moon I. S. (1997b) Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Mol. Cells 7, 749-754.
    • (1997) Mol. Cells , vol.7 , pp. 749-754
    • Jin, D.H.1    Jung, Y.W.2    Ko, B.H.3    Moon, I.S.4
  • 21
    • 0032824039 scopus 로고    scopus 로고
    • Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T
    • Klein R. C. and Castellino F. J. (1999) Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T. Neurosci. Lett. 273, 171-174.
    • (1999) Neurosci. Lett. , vol.273 , pp. 171-174
    • Klein, R.C.1    Castellino, F.J.2
  • 22
    • 0032523002 scopus 로고    scopus 로고
    • Evidence for a tetrameric structure of recombinant NMDA receptors
    • Laube B., Kuhse J. and Betz H. (1998) Evidence for a tetrameric structure of recombinant NMDA receptors. J. Neurosci. 18, 2954-2961.
    • (1998) J. Neurosci. , vol.18 , pp. 2954-2961
    • Laube, B.1    Kuhse, J.2    Betz, H.3
  • 23
    • 0031032658 scopus 로고    scopus 로고
    • The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/ NR2A/NR2B)
    • Luo J., Wang Y., Yasuda R. P., Dunah A. W. and Wolfe B. B. (1997) The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/ NR2A/NR2B). Mol. Pharmacol. 51, 79-86.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 79-86
    • Luo, J.1    Wang, Y.2    Yasuda, R.P.3    Dunah, A.W.4    Wolfe, B.B.5
  • 24
    • 0021684624 scopus 로고
    • γ-Carboxyglutamate in a neuroactive toxin
    • McIntosh J., Olivera B. M., Cruz L. and Gray W. (1984) γ-Carboxyglutamate in a neuroactive toxin. J. Biol. Chem. 259, 14343-14346.
    • (1984) J. Biol. Chem. , vol.259 , pp. 14343-14346
    • McIntosh, J.1    Olivera, B.M.2    Cruz, L.3    Gray, W.4
  • 26
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer H., Burnashev N., Laurie D. J., Sakmann B. and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 30
    • 0030722469 scopus 로고    scopus 로고
    • Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns
    • Premkumar L. S. and Auerbach A. (1997) Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns. J. Gen. Physiol. 110, 485-502.
    • (1997) J. Gen. Physiol. , vol.110 , pp. 485-502
    • Premkumar, L.S.1    Auerbach, A.2
  • 31
    • 0032584589 scopus 로고    scopus 로고
    • Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T
    • Prorok M. and Castellino F. J. (1998) Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T. J. Biol. Chem. 273, 19573-19578.
    • (1998) J. Biol. Chem. , vol.273 , pp. 19573-19578
    • Prorok, M.1    Castellino, F.J.2
  • 32
    • 0030449042 scopus 로고    scopus 로고
    • Calcium binding properties of synthetic γ-carboxyglutamic acid containing marine cone snail 'sleeper' peptides, conantokin-G and conantokin-T
    • Prorok M., Warder S. E., Blandl T. and Castellino F. J. (1996) Calcium binding properties of synthetic γ-carboxyglutamic acid containing marine cone snail 'sleeper' peptides, conantokin-G and conantokin-T. Biochemistry 35, 16528-16534.
    • (1996) Biochemistry , vol.35 , pp. 16528-16534
    • Prorok, M.1    Warder, S.E.2    Blandl, T.3    Castellino, F.J.4
  • 33
  • 34
    • 0028178739 scopus 로고
    • Both non-NMDA and NMDA glutamate receptors are necessary for memory consolidation in the day-old chick
    • Rickard N. S., Poot A. C., Gibbs M. E. and Ng K. T. (1994) Both non-NMDA and NMDA glutamate receptors are necessary for memory consolidation in the day-old chick. Behav. Neural. Biol. 62, 33-40.
    • (1994) Behav. Neural. Biol. , vol.62 , pp. 33-40
    • Rickard, N.S.1    Poot, A.C.2    Gibbs, M.E.3    Ng, K.T.4
  • 35
    • 0031035377 scopus 로고    scopus 로고
    • Determination of the solution structure of conantokin-G and conantokin-T by CD and NMR spectroscopy
    • Skjærbæk N., Nielsen K. J., Lewis R. J., Alewood P. and Craik D. J. (1997) Determination of the solution structure of conantokin-G and conantokin-T by CD and NMR spectroscopy. J. Biol. Chem. 272, 2291-2299.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2291-2299
    • Skjærbæk, N.1    Nielsen, K.J.2    Lewis, R.J.3    Alewood, P.4    Craik, D.J.5
  • 36
    • 0026698118 scopus 로고
    • Non-competitive inhibition of N-methyl-D-aspartate by conantokin-G: Evidence for an allosteric interaction at polyamine sites
    • Skolnick P., Boje K., Miller R., Pennington M. and Maccecchini M.-L. (1992) Non-competitive inhibition of N-methyl-D-aspartate by conantokin-G: evidence for an allosteric interaction at polyamine sites. J. Neurochem. 59, 1516-1521.
    • (1992) J. Neurochem. , vol.59 , pp. 1516-1521
    • Skolnick, P.1    Boje, K.2    Miller, R.3    Pennington, M.4    Maccecchini, M.-L.5
  • 37
    • 0030839762 scopus 로고    scopus 로고
    • The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions
    • Warder S. E., Chen Z., Zhu Y., Prorok M., Castellino F. J. and Ni F. (1997) The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions. FEBS Lett. 411, 19-26.
    • (1997) FEBS Lett. , vol.411 , pp. 19-26
    • Warder, S.E.1    Chen, Z.2    Zhu, Y.3    Prorok, M.4    Castellino, F.J.5    Ni, F.6
  • 38
    • 0032571376 scopus 로고    scopus 로고
    • The roles of individual γ-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T
    • Warder S. E., Prorok M., Chen Z., Li L., Zhu Y., Pedersen L. G., Ni F. and Castellino F. J. (1998) The roles of individual γ-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T. J. Biol. Chem. 273, 7512-7522.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7512-7522
    • Warder, S.E.1    Prorok, M.2    Chen, Z.3    Li, L.4    Zhu, Y.5    Pedersen, L.G.6    Ni, F.7    Castellino, F.J.8
  • 39
    • 0027092373 scopus 로고
    • Developmental changes in distribution of NMDA receptor channel subunit mRNAs
    • Watanabe M., Jnoue Y., Sakimura K. and Mishina M. (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3, 1138-1140.
    • (1992) Neuroreport , vol.3 , pp. 1138-1140
    • Watanabe, M.1    Jnoue, Y.2    Sakimura, K.3    Mishina, M.4
  • 41
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams K. (1993) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44, 851-859.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 851-859
    • Williams, K.1
  • 42
    • 0030899291 scopus 로고    scopus 로고
    • Modulation and block of ion channels: A new biology of polyamines
    • Williams K. (1997) Modulation and block of ion channels: a new biology of polyamines. Cell Signal 9, 1-13.
    • (1997) Cell Signal , vol.9 , pp. 1-13
    • Williams, K.1
  • 43
    • 0033933764 scopus 로고    scopus 로고
    • Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: In vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies
    • Williams A. J., Dave J. R., Phillips J. B., Lin Y., McCabe R. T. and Tortella F. C. (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J. Pharmacol. Exp. Ther. 294, 378-386.
    • (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 378-386
    • Williams, A.J.1    Dave, J.R.2    Phillips, J.B.3    Lin, Y.4    McCabe, R.T.5    Tortella, F.C.6
  • 44
    • 0032790229 scopus 로고    scopus 로고
    • Subunit-and site-specific pharmacology of the NMDA receptor channel
    • Yamakura T. and Shimoji K. (1999) Subunit-and site-specific pharmacology of the NMDA receptor channel. Prog. Neurobiol. 59, 279-298.
    • (1999) Prog. Neurobiol. , vol.59 , pp. 279-298
    • Yamakura, T.1    Shimoji, K.2
  • 45


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.