Formalin-induced changes of NMDA receptor subunit expression in the spinal cord of the rat

Amino Acids

Volumn 23, Issue 1-3, 2002, Pages 177-182

  Gaunitz, C ^a   Schuttler A ^b   Gillen, C ^b   Allgaier, C ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

Author keywords

Formalin; NMDA receptors; NR1 splice variants; NR2 subunits; Pain; Rat spinal cord

Indexed keywords

FORMALDEHYDE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 4; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR1 B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR2D; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; GENETIC CODE; HINDLIMB; INJECTION; LUMBAR SPINAL CORD; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; FIXATIVES; FORMALDEHYDE; MALE; PAIN MEASUREMENT; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

ANIMALIA;

EID: 0036389402     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-001-0125-3     Document Type: Conference Paper

References (34)

1. Allgaier C, Scheibler P, Müller D, Feuerstein TJ, Illes P (1999) NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones. Br J Pharmacol 126: 121-113
2. Allgaier C, Durmaz M, Müller D, Franke H, Poelchen W, WirknerK, Illes P (2001) Single-cell RT-PCR analysis of N-methyl-D-aspartate receptor subunit expression in rat locus coeruleus neurones. Naunyn-Schmiedeberg's Arch Pharmacol 363: 120-123
3. Behe P, Stern P, Wyllie DJA, Nassar M, Schoepfer R, Colquhoun D (1995) Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proc Royal Soc Lond B 262: 205-213
4. Boyce S, Wyatt A, Webb JK, O'Donnell R, Mason G, Rigby M, Sirinathsinghji D, Hill RG, Rupniak NMJ (1999) Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacol 38: 611-623
5. Chandler LJ, Harris RA, Crews FT (1998) Ethanol tolerance and synaptic plasticity. Trends Pharmacol Sci 19: 491-495
6. Chaplan SR, Malmberg AB, Yaksh TL (1997) Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther 280: 829-839
7. Coderre TJ, Vaccarino AL, Melzack R (1990) Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res 535: 155-158
8. Coderre TJ, Fundytus ME, McKenna JE, Dalal S, Melzack R (1993) The formalin test: a validation of the weighted-scores method of behavioural pain rating, Pain 54: 43-50
9. Dickenson AH (1997) NMDA receptor antagonists: interactions with opioids. Acta Anaesthesiol Scand 41: 112-115
10. Dickenson AH, Sullivan AF (1990) Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat. Brain Res 506: 31-39
11. Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain
12. Durand GM, Bennett MVL, Zukin RS (1993) Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci USA 90: 6731-6735
13. Elliott KJ, Brodsky M, Hynansky AD, Foley KM, Inturrisi CE (1995) Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA. Pain 61: 401-409
14. Flint AC, Maisch US, Weishaupt JH, Kriegstein AR, Monyer H (1997) NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex. J Neurosci 17: 2469-2476
15. Grossman SD, Wolfe BB, Yasuda RP, Wrathall JR (2000) Changes in NMDA receptor subunit expression in response to contusive spinal cord injury. J Neurochem 75: 174-184
16. Hollmann M, Boulter J, Maron C, Beasley L, Sullivan J, Pecht G, Heinemann S (1993) Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 10: 943-954
17. Laurie DJ, Seeburg PH (1994) Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J Neurosci 14: 3180-3194
18. Laurie DJ, Putzke J, Zieglgänsberger W, Seeburg PH, Tölle TR (1995) The distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain. Mol Brain Res 32: 94-108
19. Luque JM, Bleuel Z, Malherbe P, Richards JG (1994) Alternatively spliced isoforms of theN-methyl-D-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord. Neuroscience 63: 629-635
20. Monaghan DT, Andaloro VJ, Skifter DA (1998) Molecular determinants of NMDA receptor pharmacological diversity. Progr Brain Res 116: 171-190
21. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540
22. +-treatment. Naunyn-Schmiedeberg's Arch Pharmacol 361: R30
23. Parsons CG, Danysz W, Quack G (1998) Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect 11: 523-569
24. Tölle TR, Berthele A, Zieglgänsberger W, Seeburg P, Wisden W (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci 13: 5009-5028
25. Tölle TR, Berthele A, Laurie DJ, Seeburg PH, Zieglgänsberger W (1995) Cellular and subcellular distribution of NMDAR1 splice variant mRNA in the rat lumbar spinal cord. Eur J Neurosci 7: 1235-1244
26. Traynelis SF, Hartley M, Heinemann SF (1995) Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science 268: 873-876
27. Vaccarino AL, Marek P, Kest B, Weber E, Keana JF, Liebeskind JC (1993) NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin. Brain Res 615: 331-334
28. Vallano ML (1998) Developmental aspects of NMDA receptor function. Crit Rev Neurobiol 12: 177-204
29. Vallano ML, Lambolez B, Audinat E, Rossier J (1996) Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells. J Neurosci 16: 631-639
30. Wheeler-Aceto H, Porreca F, Cowan A (1990) The rat paw formalin test: comparison of noxious agents. Pain 40: 229-238
31. Woolf CJ, Thompson SW (1991) The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 44: 293-299
32. Yung KKL (1998) Localization of glutamate receptors in dorsal horn of rat spinal cord. NeuroReport 9: 1639-1644
33. Zhong J, Carrozza DP, Williams K, Pritchett DB, Molinoff PB (1995) Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 64: 531-539
34. Zukin RS, Bennett MVI (1995) Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends Neurosci 18: 306-313