메뉴 건너뛰기




Volumn 459, Issue 1, 2003, Pages 49-58

Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats

Author keywords

Central; NMDA (N methyl D aspartate); Pain; Sensitization; Spinal cord

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; DIZOCILPINE; FREUND ADJUVANT;

EID: 0037427965     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02828-5     Document Type: Article
Times cited : (53)

References (52)
  • 1
    • 0025286174 scopus 로고
    • Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord
    • Aanonsen L.M., Lei S., Wilcox G.L. Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord. Pain. 41:1990;309-321.
    • (1990) Pain , vol.41 , pp. 309-321
    • Aanonsen, L.M.1    Lei, S.2    Wilcox, G.L.3
  • 2
    • 0031913847 scopus 로고    scopus 로고
    • Sensitization of pain pathways in the spinal cord: Cellular mechanisms
    • Baranauskas G., Nistri A. Sensitization of pain pathways in the spinal cord: cellular mechanisms. Prog. Neurobiol. 54:1998;349-365.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 349-365
    • Baranauskas, G.1    Nistri, A.2
  • 3
    • 0034678026 scopus 로고    scopus 로고
    • Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury
    • Bennett A.D., Everhart A.W., Hulsebosch C.E. Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury. Brain Res. 859:2000;72-82.
    • (2000) Brain Res. , vol.859 , pp. 72-82
    • Bennett, A.D.1    Everhart, A.W.2    Hulsebosch, C.E.3
  • 4
    • 0028867313 scopus 로고
    • Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats
    • Bian D., Nichols M.L., Ossipov M.H., Lai J., Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. NeuroReport. 6:1995;1981-1984.
    • (1995) NeuroReport , vol.6 , pp. 1981-1984
    • Bian, D.1    Nichols, M.L.2    Ossipov, M.H.3    Lai, J.4    Porreca, F.5
  • 5
    • 0028787329 scopus 로고
    • Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation
    • Carlton S.M., Hargett G.L. Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation. Neurosci. Lett. 198:1995;115-118.
    • (1995) Neurosci. Lett. , vol.198 , pp. 115-118
    • Carlton, S.M.1    Hargett, G.L.2
  • 6
    • 0030933616 scopus 로고    scopus 로고
    • Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat
    • Chaplan S.R., Malmberg A.B., Yaksh T.L. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J. Pharmacol. Exp. Ther. 280:1997;829-838.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 829-838
    • Chaplan, S.R.1    Malmberg, A.B.2    Yaksh, T.L.3
  • 7
    • 0028594101 scopus 로고
    • The utility of excitatory amino acid (EAA) antagonists as analgesic agents: I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests
    • Coderre T.J., Van Empel I. The utility of excitatory amino acid (EAA) antagonists as analgesic agents: I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests. Pain. 59:1994;345-352.
    • (1994) Pain , vol.59 , pp. 345-352
    • Coderre, T.J.1    Van Empel, I.2
  • 8
    • 0025769640 scopus 로고
    • MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy
    • Davar G., Hama A., Deykin A., Vos B., Maciewicz R. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res. 553:1991;327-330.
    • (1991) Brain Res. , vol.553 , pp. 327-330
    • Davar, G.1    Hama, A.2    Deykin, A.3    Vos, B.4    Maciewicz, R.5
  • 9
    • 0026500432 scopus 로고
    • Activity-dependent neuronal plasticity following tissue injury and inflammation
    • Dubner R., Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15:1992;96-103.
    • (1992) Trends Neurosci. , vol.15 , pp. 96-103
    • Dubner, R.1    Ruda, M.A.2
  • 10
    • 0028890414 scopus 로고
    • The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy
    • Eisenberg E., LaCross S., Strassman A.M. The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy. Neurosci. Lett. 187:1995;17-20.
    • (1995) Neurosci. Lett. , vol.187 , pp. 17-20
    • Eisenberg, E.1    LaCross, S.2    Strassman, A.M.3
  • 11
    • 0032910582 scopus 로고    scopus 로고
    • Acute amitriptyline in a rat model of neuropathic pain: Differential symptom and route effects
    • Esser M.J., Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain. 80:1999;643-653.
    • (1999) Pain , vol.80 , pp. 643-653
    • Esser, M.J.1    Sawynok, J.2
  • 13
    • 0034677145 scopus 로고    scopus 로고
    • Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat
    • Garry M.G., Malik S., Yu J., Davis M.A., Yang J. Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. NeuroReport. 11:2000;49-55.
    • (2000) NeuroReport , vol.11 , pp. 49-55
    • Garry, M.G.1    Malik, S.2    Yu, J.3    Davis, M.A.4    Yang, J.5
  • 14
    • 0036147446 scopus 로고    scopus 로고
    • Selective antihyperalgesic effect of [Ser(1)] histogranin on complete Freund's adjuvant-induced hyperalgesia in rats
    • Hama A., Sagen J. Selective antihyperalgesic effect of [Ser(1)] histogranin on complete Freund's adjuvant-induced hyperalgesia in rats. Pain. 95:2002;15-21.
    • (2002) Pain , vol.95 , pp. 15-21
    • Hama, A.1    Sagen, J.2
  • 15
    • 0032929612 scopus 로고    scopus 로고
    • NMDA-induced spinal hypersensitivity is reduced by naturally derived peptide analog [Ser1]histogranin
    • Hama A., Siegan J., Herzberg U., Sagen J. NMDA-induced spinal hypersensitivity is reduced by naturally derived peptide analog [Ser1]histogranin. Pharmacol. Biochem. Behav. 62:1999;67-74.
    • (1999) Pharmacol. Biochem. Behav. , vol.62 , pp. 67-74
    • Hama, A.1    Siegan, J.2    Herzberg, U.3    Sagen, J.4
  • 16
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
    • (1988) Pain , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3    Flores, C.4    Joris, J.5
  • 17
    • 0023907904 scopus 로고
    • Analgesic effects of intrathecally applied noradrenergic compounds in the developing rat: Differences due to thermal vs. mechanical nociception
    • Hughes H.E., Barr G.A. Analgesic effects of intrathecally applied noradrenergic compounds in the developing rat: differences due to thermal vs. mechanical nociception. Brain Res. 469:1988;109-120.
    • (1988) Brain Res. , vol.469 , pp. 109-120
    • Hughes, H.E.1    Barr, G.A.2
  • 18
    • 0034936663 scopus 로고    scopus 로고
    • Mechanisms of inflammatory pain
    • Kidd B.L., Urban L.A. Mechanisms of inflammatory pain. Br. J. Anaesth. 87:2001;3-11.
    • (2001) Br. J. Anaesth. , vol.87 , pp. 3-11
    • Kidd, B.L.1    Urban, L.A.2
  • 19
    • 0030757190 scopus 로고    scopus 로고
    • NMDA receptor are important for both mechanical and thermal allodynia from peripheral nerve injury in rats
    • Kim Y.I., Na H.S., Yoon Y.W., Han H.C., Ko K.H., Hong S.K. NMDA receptor are important for both mechanical and thermal allodynia from peripheral nerve injury in rats. NeuroReport. 8:1997;2149-2153.
    • (1997) NeuroReport , vol.8 , pp. 2149-2153
    • Kim, Y.I.1    Na, H.S.2    Yoon, Y.W.3    Han, H.C.4    Ko, K.H.5    Hong, S.K.6
  • 21
    • 0025981539 scopus 로고
    • Intrathecal injections of galanin and its antiserum affect nociceptive response of rat to mechanical, but not thermal, stimuli
    • Kuraishi Y., Kawamura M., Yamaguchi T., Houtani T., Kawabata S., Futaki S., Fujii N., Satoh M. Intrathecal injections of galanin and its antiserum affect nociceptive response of rat to mechanical, but not thermal, stimuli. Pain. 44:1991;321-324.
    • (1991) Pain , vol.44 , pp. 321-324
    • Kuraishi, Y.1    Kawamura, M.2    Yamaguchi, T.3    Houtani, T.4    Kawabata, S.5    Futaki, S.6    Fujii, N.7    Satoh, M.8
  • 22
    • 0037052784 scopus 로고    scopus 로고
    • The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain
    • Lee T.H., Wang C.J., Wu P.C., Buerkle H., Lin S.H., Yang L.C. The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. Life Sci. 70:2002;3039-3047.
    • (2002) Life Sci. , vol.70 , pp. 3039-3047
    • Lee, T.H.1    Wang, C.J.2    Wu, P.C.3    Buerkle, H.4    Lin, S.H.5    Yang, L.C.6
  • 23
    • 0026795636 scopus 로고
    • Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition
    • Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 257:1992;1276-1279.
    • (1992) Science , vol.257 , pp. 1276-1279
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 24
    • 0027057580 scopus 로고
    • Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy
    • Mao J., Price D.D., Hayes R.L., Lu J., Mayer D.J. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res. 598:1992;271-278.
    • (1992) Brain Res. , vol.598 , pp. 271-278
    • Mao, J.1    Price, D.D.2    Hayes, R.L.3    Lu, J.4    Mayer, D.J.5
  • 25
    • 0027466924 scopus 로고
    • Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy
    • Mao J., Price D.D., Hayes R.L., Lu J., Mayer D.J., Frenk H. Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy. Brain Res. 605:1993;164-168.
    • (1993) Brain Res. , vol.605 , pp. 164-168
    • Mao, J.1    Price, D.D.2    Hayes, R.L.3    Lu, J.4    Mayer, D.J.5    Frenk, H.6
  • 27
    • 0033867251 scopus 로고    scopus 로고
    • Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision
    • Pogatzki E.M., Zahn P.K., Brennan T.J. Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision. Anesthesiology. 93:2000;489-496.
    • (2000) Anesthesiology , vol.93 , pp. 489-496
    • Pogatzki, E.M.1    Zahn, P.K.2    Brennan, T.J.3
  • 28
    • 0029937786 scopus 로고    scopus 로고
    • Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy
    • Qian J., Brown S.D., Carlton S.M. Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy. Brain Res. 715:1996;51-62.
    • (1996) Brain Res. , vol.715 , pp. 51-62
    • Qian, J.1    Brown, S.D.2    Carlton, S.M.3
  • 29
    • 84960959252 scopus 로고
    • A method for measurement of analgesic activity on inflamed tissue
    • Randall L.O., Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther. 111:1957;409-419.
    • (1957) Arch. Int. Pharmacodyn. Ther. , vol.111 , pp. 409-419
    • Randall, L.O.1    Selitto, J.J.2
  • 30
    • 0027501057 scopus 로고
    • NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw
    • Ren K., Dubner R. NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw. Neurosci. Lett. 163:1993;22-26.
    • (1993) Neurosci. Lett. , vol.163 , pp. 22-26
    • Ren, K.1    Dubner, R.2
  • 31
    • 0026709480 scopus 로고
    • The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation
    • Ren K., Hylden J.L., Williams G.M., Ruda M.A., Dubner R. The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain. 50:1992;331-344.
    • (1992) Pain , vol.50 , pp. 331-344
    • Ren, K.1    Hylden, J.L.2    Williams, G.M.3    Ruda, M.A.4    Dubner, R.5
  • 32
    • 0026669928 scopus 로고
    • The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats
    • Ren K., Williams G.M., Hylden J.L., Ruda M.A., Dubner R. The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats. Eur. J. Pharmacol. 219:1992;235-243.
    • (1992) Eur. J. Pharmacol. , vol.219 , pp. 235-243
    • Ren, K.1    Williams, G.M.2    Hylden, J.L.3    Ruda, M.A.4    Dubner, R.5
  • 33
    • 0028076022 scopus 로고
    • Inflammation and hyperalgesia in rats neonatally treated with capsaicin: Effects on two classes of nociceptive neurons in the superficial dorsal horn
    • Ren K., Williams G.M., Ruda M.A., Dubner R. Inflammation and hyperalgesia in rats neonatally treated with capsaicin: effects on two classes of nociceptive neurons in the superficial dorsal horn. Pain. 59:1994;287-300.
    • (1994) Pain , vol.59 , pp. 287-300
    • Ren, K.1    Williams, G.M.2    Ruda, M.A.3    Dubner, R.4
  • 34
    • 0020672388 scopus 로고
    • Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli
    • Salt T.E., Hill R.G. Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli. Brain Res. 263:1983;167-171.
    • (1983) Brain Res. , vol.263 , pp. 167-171
    • Salt, T.E.1    Hill, R.G.2
  • 35
    • 0025011001 scopus 로고
    • Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones
    • Sher G.D., Mitchell D. Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones. Neurosci. Lett. 119:1990;199-202.
    • (1990) Neurosci. Lett. , vol.119 , pp. 199-202
    • Sher, G.D.1    Mitchell, D.2
  • 36
    • 0031962566 scopus 로고    scopus 로고
    • Adrenal medullary transplants attenuate sensorimotor dysfunction in rats with peripheral neuropathy
    • Siegan J.B., Sagen J. Adrenal medullary transplants attenuate sensorimotor dysfunction in rats with peripheral neuropathy. Pharmacol. Biochem. Behav. 59:1998;97-104.
    • (1998) Pharmacol. Biochem. Behav. , vol.59 , pp. 97-104
    • Siegan, J.B.1    Sagen, J.2
  • 37
    • 0030944381 scopus 로고    scopus 로고
    • Suppression of neuropathic pain by a naturally-derived peptide with NMDA antagonist activity
    • Siegan J., Hama A., Sagen J. Suppression of neuropathic pain by a naturally-derived peptide with NMDA antagonist activity. Brain Res. 755:1997;331-334.
    • (1997) Brain Res. , vol.755 , pp. 331-334
    • Siegan, J.1    Hama, A.2    Sagen, J.3
  • 38
    • 0026445264 scopus 로고
    • An experimental arthritis in rats: Dorsal horn aspartate and glutamate increases
    • Sluka K.A., Westlund K.N. An experimental arthritis in rats: dorsal horn aspartate and glutamate increases. Neurosci. Lett. 145:1992;141-144.
    • (1992) Neurosci. Lett. , vol.145 , pp. 141-144
    • Sluka, K.A.1    Westlund, K.N.2
  • 39
    • 0027440588 scopus 로고
    • Spinal cord amino acid release and content in an arthritis model: The effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists
    • Sluka K.A., Westlund K.N. Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists. Brain Res. 627:1993;89-103.
    • (1993) Brain Res. , vol.627 , pp. 89-103
    • Sluka, K.A.1    Westlund, K.N.2
  • 40
    • 0028057565 scopus 로고
    • Pre treatment with MK-801, a non-competitive NMDA antagonists, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation
    • Smith G.D., Wiseman J., Harrison S.M., Elliott P.J., Birch P.J. Pre treatment with MK-801, a non-competitive NMDA antagonists, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation. Neurosci. Lett. 165:1994;79-83.
    • (1994) Neurosci. Lett. , vol.165 , pp. 79-83
    • Smith, G.D.1    Wiseman, J.2    Harrison, S.M.3    Elliott, P.J.4    Birch, P.J.5
  • 41
    • 33749364692 scopus 로고    scopus 로고
    • Suppressive effects of ketamine on neuropathic pain
    • Sonoda H., Omote K. Suppressive effects of ketamine on neuropathic pain. Masui, Jpn. J. Anesth. 47:1998;136-144.
    • (1998) Masui, Jpn. J. Anesth. , vol.47 , pp. 136-144
    • Sonoda, H.1    Omote, K.2
  • 42
    • 0035145892 scopus 로고    scopus 로고
    • Effects of glutamate receptor antagonists on spinal dorsal doral horn neurons during zymosan-induced inflammation in rats
    • Spraggins D.S., Turnbach M.E., Randich A. Effects of glutamate receptor antagonists on spinal dorsal doral horn neurons during zymosan-induced inflammation in rats. J. Pain. 2:2001;12-24.
    • (2001) J. Pain , vol.2 , pp. 12-24
    • Spraggins, D.S.1    Turnbach, M.E.2    Randich, A.3
  • 43
    • 0027210790 scopus 로고
    • Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
    • Tal M., Bennett G.J. Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat. Neurosci. Lett. 151:1993;107-110.
    • (1993) Neurosci. Lett. , vol.151 , pp. 107-110
    • Tal, M.1    Bennett, G.J.2
  • 44
    • 0028064408 scopus 로고
    • Neuropathic pain sensations are differentially sensitive to dextrorphan
    • Tal M., Bennett G.J. Neuropathic pain sensations are differentially sensitive to dextrorphan. NeuroReport. 5:1994;1438-1440.
    • (1994) NeuroReport , vol.5 , pp. 1438-1440
    • Tal, M.1    Bennett, G.J.2
  • 46
    • 0030986006 scopus 로고    scopus 로고
    • Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats
    • Wegert S., Ossipov M.H., Nichols M.L., Bian D., Vanderah T.W., Malan T.P. Jr., Porreca F. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats. Pain. 71:1997;57-64.
    • (1997) Pain , vol.71 , pp. 57-64
    • Wegert, S.1    Ossipov, M.H.2    Nichols, M.L.3    Bian, D.4    Vanderah, T.W.5    Malan T.P., Jr.6    Porreca, F.7
  • 48
    • 0017036162 scopus 로고
    • Chronic catheterization of the spinal subarachnoid space
    • Yaksh T., Rudy T. Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17:1976;1031-1036.
    • (1976) Physiol. Behav. , vol.17 , pp. 1031-1036
    • Yaksh, T.1    Rudy, T.2
  • 49
    • 0026588069 scopus 로고
    • Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists
    • Yamamoto T., Yaksh T.L. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain. 49:1992;121-128.
    • (1992) Pain , vol.49 , pp. 121-128
    • Yamamoto, T.1    Yaksh, T.L.2
  • 50
    • 0031983301 scopus 로고    scopus 로고
    • Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain
    • Zahn P.K., Brennan T.J. Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain. Anesthesiology. 88:1998;143-156.
    • (1998) Anesthesiology , vol.88 , pp. 143-156
    • Zahn, P.K.1    Brennan, T.J.2
  • 51
    • 0032559273 scopus 로고    scopus 로고
    • Pre-emptive intrathecal Mk-801, a non-competitive N-methyl-D-aspartate receptor antagonist, inhibits the up-regulation of spinal dynorphin mRNA and hyperalgesia in a rat model of chronic inflammation
    • Zhang R.X., Ruda M.A., Qiao J.T. Pre-emptive intrathecal Mk-801, a non-competitive N-methyl-D-aspartate receptor antagonist, inhibits the up-regulation of spinal dynorphin mRNA and hyperalgesia in a rat model of chronic inflammation. Neurosci. Lett. 241:1998;57-60.
    • (1998) Neurosci. Lett. , vol.241 , pp. 57-60
    • Zhang, R.X.1    Ruda, M.A.2    Qiao, J.T.3
  • 52
    • 0035028312 scopus 로고    scopus 로고
    • Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat
    • Zheng J.H., Chen J. Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat. Neuropeptides. 35:2001;32-44.
    • (2001) Neuropeptides , vol.35 , pp. 32-44
    • Zheng, J.H.1    Chen, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.