Pharmacokinetics and metabolism of ligustilide, a major bioactive component in rhizoma chuanxiong, in the rat

Drug Metabolism and Disposition

Volumn 36, Issue 2, 2008, Pages 400-408

  Yan, Ru ^a   Nga, Ling Ko ^a   Li, Song Lin ^a   Yun, Kau Tam ^b   Lin, Ge ^a,c  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b Sinoveda Canada Inc   (Canada)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLIDENEPHTHALIDE; DRUG METABOLITE; LIGUSTILIDE; PHTHALIDE DERIVATIVE; SENKYUNALIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; RHIZOME;

4-BUTYROLACTONE; ANIMALS; DRUG ADMINISTRATION ROUTES; DRUGS, CHINESE HERBAL; GASTRIC JUICE; INTESTINAL SECRETIONS; LIGUSTICUM; MALE; MICROSOMES; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 38749153569     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.017707     Document Type: Article

References (36)

1. 2+ influx and release. Vascul Pharmacol 45:171-176.
2. Chan SSK, Cheng TY, and Lin G (2007) Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. J Ethnopharmacol 111:677-680.
3. Chan SSK, Choi AO, Jones RL, and Lin G (2006) Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong, in rat isolated aorta. Eur J Pharmacol 537:111-117.
4. Chong ZZ and Feng YP (1999) dl-3-n-Butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats. Acta Pharmacol Sin 20:509-512.
5. Cui F, Feng L, and Hu J (2006) Factors affecting stability of z-ligustilide in the volatile oil of radix angelicae sinensis and ligusticum chuanxiong and its stability prediction. Drug Dev Ind Pharm 32:747-755.
6. Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, and Pauli GF (2006) Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod 69:536-541.
7. Du J, Bai B, Kuang X, Yu Y, Wang C, Ke Y, Xu Y, Tzang AH, and Qian ZM (2006) Ligustilide inhibits spontaneous and agonists- or K(+) depolarization-induced contraction of rat uterus. J Ethnopharmacol 108:54-58.
8. Hussain MD, Tam YK, Gray MR, and Coutts RT (1994) Mechanism of time-dependent kinetics of diltiazem in the isolated perfused rat liver. Drug Metab Dispos 22:36-42.
9. Ko NL, Choo CK, Tam YK, and Lin G (2003) Study of the oral absorption of the active ingredients of Rhizoma Chuanxiong. AAPS Pharm Sci 5:R6078.
10. Ko WC, Liao CC, Shih CH, Lei CB, and Chen CM (2002) Relaxant effects of butylidenephthalide in isolated dog blood vessels. Planta Med 68:1004-1009.
11. Ko WC, Sheu JR, Leu YR, Tzeng SH, and Chen CM (1997) Stereoselectivity of butylidenephthalide on voltage-dependent calcium channels in guinea-pig isolated ileum. J Pharm Pharmacol 49:1121-1125.
12. Ko WC, Sheu JR, Tzeng SH, and Chen CM (1998) The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats. Planta Med 64:229-232.
13. Kobayashi S, Mimura Y, Notoya K, Kimura I, and Kimura M (1992) Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells. Jpn J Pharmacol 60:397-401.
14. Li HX, Ding MY, and Yu JY (2002) Separation and identification of the phthalic anhydride derivatives of Liqusticum chuanxiong Hort by GC-MS, TLC, HPLC-DAD, and HPLC-MS. J Chromatogr Sci 40:156-161.
15. Li LI (2005) 2004 Market survey of drugs used for the cardiac diseases in China urban populations [100md (Baimu Medicine web site]. Available at: http://www.100md.com/html/DirDu/2005/06/23/62/99/57.htm. Accessed January 11, 2006.
16. Li SL, Chan SSK, Lin G, Ling L, Yan R, Chung HS, and Tam YK (2003) Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry. Planta Med 69:445-451.
17. Li SL, Lin G, and Tam YK (2006) Time-course accumulation of main bioactive components in rhizome of Ligusticum chuanxiong Hort. Planta Med 72:278-280.
18. Li SL, Yan Ru, Tam YK, and Lin G (2007) Post-harvest alteration of the main chemical ingredients in Rhizoma Chuanxiong. Chem Pharm Bull 55:140-144.
19. Liang MJ, He LC, and Yang GD (2005) Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong. Life Sci 78:128-133.
20. Lin G, Cui YY, and Hawes EM (2000) Characterization of rat liver microsomal metabolism of clivorine, a hepatotoxic otonecine-type pyrrolizidine alkaloid. Drug Metab Dispos 28:1475-1483.
21. Lin G, Tang J, Liu XQ, Jiang Y, and Zheng J (2007) Deacetylclivorine: a gender-selective metabolite of clivorine formed in female SD rat liver microsomes. Drug Metab Dispos 35:607-613.
22. Lin LZ, He XG, Lian LZ, King W, and Elliott J (1998) Liquid chromatographic-electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide. J Chromatogr A 810:71-79.
23. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
24. Lu Q, Qiu TQ, and Yang H (2006) Ligustilide inhibits vascular smooth muscle cells proliferation. Eur J Pharmacol 542:136-140.
25. Matsumoto K, Kohno SI, Ojima K, Tezuka Y, Kadota S, and Watanabe H (1998) Effects of methylenechloride-soluble fraction of Japanese Angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated rats. Life Sci 62:2073-2082.
26. Naito T, Kubota K, Shimoda Y, Sato T, Ikeya Y, Okada M, and Maruno M (1995) Effects of constituents in a Chinese crude drug, Ligustici Chuanxiong Rhizoma on vasoconstriction and blood viscosity. Nat Med 49:288-292.
27. Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
28. Shi YF, He LC, and Wang SC (2006) Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry. Biomed Chromatogr 20:993-998.
29. Shih YH, Wu SL, Chiou WF, Ku HH, Ko TL, and Fu YS (2002) Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture. Neuroreport 13:515-519.
30. Su J, He L, Zhang NN, and Ho PC (2006) Evaluation of tributyrin lipid emulsion with affinity of low-density lipoprotein: pharmacokinetics in adult male Wistar rats and cellular activity on caco-2 and HepG2 cell lines. J Pharmacol Exp Ther 316:62-70.
31. Sun SR, Huang X, and Zhang L (2002) Advances in studies on pharmacokinetics, pharmacodynamics and clinical research of Suxiao Jiuxin Wan. Chin Traditional Herbal Drugs 33:89-91.
32. The State Pharmacopoeia Commission of P.R. China (2005) Rhizoma Chuanxiong, in Pharmacopoeia of the People's Republic of China, vol I, pp 28, Chemical Industry Press, Beijing.
33. The United States Pharmacopeial Convention (2006) Gastric fluid, simulated; intestinal fluid, simulated, in The United States Pharmacopeia, 29 revision, pp 3171, The United States Pharmacopeial Convention, Rockville, MD.
34. Williams DE, Reed RL, Kedzierski B, Dannan GA, Guengerich FP, and Buhler DR (1989) Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver. Drug Metab Dipos 17:387-392.
35. Yan R, Li SL, Chung HS, Tam YK, and Lin G (2005) Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography. J Pharm Biomed Anal 37:87-95.
36. Yan R, Lin G, Ko NL, and Tam YK (2007) Low oral bioavailability and pharmacokinetics of senkyunolide A, a major bioactive component in Rhizoma Chuanxiong, in the rat. Ther Drug Monit 29:49-56.