Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

Cell Research

Volumn 18, Issue 11, 2008, Pages 1096-1104

  Zhang, Min ^a   Tian, Yang ^a   Wang, Rui Peng ^a   Gao, Dong ^a   Zhang, Yan ^a   Diao, Fei Ci ^a   Chen, Dan Ying ^a   Zhai, Zhong He ^a   Shu, Hong Bing ^b  

^a PEKING UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Antiviral response; E3 ligase; Feedback regulation; IRF3; RBCK1; Type I IFNs

Indexed keywords

ANTIVIRUS AGENT; INTERFERON; INTERFERON REGULATORY FACTOR 3; RBCK1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL LINE; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; METABOLISM; SENDAI VIRUS; SIGNAL TRANSDUCTION; VIRUS CULTURE;

ANTIVIRAL AGENTS; CELL LINE; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; PLAQUE ASSAY; SENDAI VIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

HUMAN PARAINFLUENZA VIRUS 1; SENDAI VIRUS;

EID: 55549146091     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2008.277     Document Type: Article

References (44)

1. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264:1415-1421.
2. Siegal FP, Kadowaki N, Shodell M, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999; 284:1835-1837.
3. Levy DE, Garcia-Sastre A. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev 2001; 12:143-156.
4. Theofilopoulos AN, Baccala R, Beutler B, Kono DH. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol 2005; 23:307-336.
5. Au WC, Moore PA, Lowther W, Juang YT, Pitha PM. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc Natl Acad Sci USA 1995; 92:11657-11661.
6. Wathelet MG, Lin CH, Parekh BS, et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell 1998; 1:507-518.
7. Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5:730-737.
8. Meylan E, Curran J, Hofmann K, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437:1167-1172.
9. Seth RB, Sun L, Ea CK, Chen ZJ. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 2005; 122:669-682.
10. Kawai T, Takahashi K, Sato S, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6:981-988.
11. Xu LG, Wang YY, Han KJ, et al. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19:727-740.
12. Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006; 7:131-137.
13. Sun Q, Sun L, Liu HH, et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 2006; 24:633-642.
14. Lin R, Heylbroeck C, Pitha PM, Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol 1998; 18:2986-2996.
15. Hiscott J, Pitha P, Genin P, et al. Triggering the interferon response: the role of IRF-3 transcription factor. J Interferon Cytokine Res 1999; 19:1-13.
16. Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003; 4:491-496.
17. Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-1151.
18. Rothenfusser S, Goutagny N, DiPerna G, et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol 2005; 175:5260-5268.
19. Yoneyama M, Kikuchi M, Matsumoto K, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005; 175:2851-2858.
20. Komuro A, Horvath CM. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J Virol 2006; 80:12332-12342.
21. Saito T, Hirai R, Loo YM, et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci USA 2007; 104:582-587.
22. Diao F, Li S, Tian Y, et al. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci USA 2007; 104:11706-11711.
23. Huang J, Liu T, Xu LG, et al. SIKE is an IKK epsilon/TBK1- associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J 2005; 24:4018-4028.
24. Lin R, Yang L, Nakhaei P, et al. Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. J Biol Chem 2006; 281:2095-2103.
25. Kayagaki N, Phung Q, Chan S, et al. DUBA: a deubiquitinase that regulates type I interferon production. Science 2007; 318:1628-1632.
26. Arimoto K, Takahashi H, Hishiki T, et al. Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci USA 2007; 104:7500-7505.
27. Gack MU, Shin YC, Joo CH, et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007; 446:916-920.
28. Yamanaka K, Ishikawa H, Megumi Y, et al. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nat Cell Biol 2003; 5:336-340.
29. Ishikawa H, Kato M, Hori H, et al. Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2. Mol Cell 2005; 19:171-181.
30. Iwai K, Ishikawa H, Kirisako T. Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1. Methods Enzymol 2005; 398:256-271.
31. Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E. The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein. J Biol Chem 1997; 272:16482-16489.
32. Marin I, Ferrus A. Comparative genomics of the RBR family, including the Parkinson's disease-related gene parkin and the genes of the ariadne subfamily. Mol Biol Evol 2002; 19:2039-2050.
33. Bayle J, Lopez S, Iwai K, Dubreuil P, De Sepulveda P. The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. FEBS Lett 2006; 580:2609-2614.
34. Tian Y, Zhang Y, Zhong B, et al. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem 2007; 282:16776-16782.
35. Kothapalli R, Nyland SB, Kusmartseva I, et al. Constitutive production of proinflammatory cytokines RANTES, MIP-1beta and IL-18 characterizes LGL leukemia. Int J Oncol 2005; 26:529-535.
36. Bach JF. Infections and autoimmune diseases. J Autoimmun 2005; 25 Suppl:74-80.
37. Rotondi M, Chiovato L, Romagnani S, Serio M, Romagnani P. Role of chemokines in endocrine autoimmune diseases. Endocr Rev 2007; 28:492-520.
38. Mondini M, Vidali M, Airo P, et al. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann N Y Acad Sci 2007; 1110:47-56.
39. Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL. The herpes simplex virus ICP0 RING finger domain inhibits IRF3-and IRF7-mediated activation of interferon-stimulated genes. J Virol 2004; 78:1675-1684.
40. Henderson G, Zhang Y, Jones C. The Bovine herpesvirus 1 gene encoding infected cell protein 0 (bICP0) can inhibit interferon-dependent transcription in the absence of other viral genes. J Gen Virol 2005; 86:2697-2702.
41. Bibeau-Poirier A, Gravel SP, Clement JF, et al. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J Immunol 2006; 177:5059-5067.
42. Saitoh T, Tun-Kyi A, Ryo A, et al. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol 2006; 7:598-605.
43. Saira K, Zhou Y, Jones C. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 and, consequently, inhibits beta interferon promoter activity. J Virol 2007; 81:3077-3086.
44. Graff JW, Ewen J, Ettayebi K, Hardy ME. Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability. J Gen Virol 2007; 88:613-620.