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Volumn 147, Issue 7, 2008, Pages 1080-1088

A reanalysis of 409 European-ancestry and African American schizophrenia pedigrees reveals significant linkage to 8p23.3 with evidence of locus heterogeneity

Author keywords

Epidemiology; Genetic susceptibility; Genetics; Mental disorders; Psychiatry

Indexed keywords

AFRICAN AMERICAN; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC LINKAGE; HUMAN; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 55349118848     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30722     Document Type: Article
Times cited : (6)

References (73)
  • 1
    • 27244437783 scopus 로고    scopus 로고
    • Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers
    • Abecasis GR, Wigginton JE. 2005. Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers. Am J Hum Genet 77:754-767.
    • (2005) Am J Hum Genet , vol.77 , pp. 754-767
    • Abecasis, G.R.1    Wigginton, J.E.2
  • 2
    • 12144287883 scopus 로고    scopus 로고
    • Genomewide scan in families with schizophrenia from the founder population of afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1
    • Abecasis GR, Burt RA, Hall D, Bochum S, Doheny KF, Lundy SL, Torrington M, Roos JL, Gogos JA, Karayiorgou M. 2004. Genomewide scan in families with schizophrenia from the founder population of afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am J Hum Genet 74(3):403-417.
    • (2004) Am J Hum Genet , vol.74 , Issue.3 , pp. 403-417
    • Abecasis, G.R.1    Burt, R.A.2    Hall, D.3    Bochum, S.4    Doheny, K.F.5    Lundy, S.L.6    Torrington, M.7    Roos, J.L.8    Gogos, J.A.9    Karayiorgou, M.10
  • 3
    • 55349116280 scopus 로고
    • Diagnostic and statistical manual of mental disorders
    • American Psychiatric Association, DSM-IV, Washington, DC: American Psychiatric Press, Inc
    • American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders, fourth editition (DSM-IV). Washington, DC: American Psychiatric Press, Inc.
    • (1994) fourth editition
  • 4
    • 28144444187 scopus 로고    scopus 로고
    • Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    • Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, et al. 2005. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet 77(6):937-944.
    • (2005) Am J Hum Genet , vol.77 , Issue.6 , pp. 937-944
    • Arinami, T.1    Ohtsuki, T.2    Ishiguro, H.3    Ujike, H.4    Tanaka, Y.5    Morita, Y.6    Mineta, M.7    Takeichi, M.8    Yamada, S.9    Imamura, A.10
  • 6
    • 0025964920 scopus 로고
    • Allele frequency estimation from data on relatives
    • Boehnke M. 1991. Allele frequency estimation from data on relatives. Am J Hum Genet 48(1):22-25.
    • (1991) Am J Hum Genet , vol.48 , Issue.1 , pp. 22-25
    • Boehnke, M.1
  • 9
    • 84878770302 scopus 로고    scopus 로고
    • Broman KW, Matsumoto N, Giglio S, Martin CL, Roseberry JA, Zuffardi O, Ledbetter DH, Weber JL. 2003. Common long human inversion polymorphism on chromosome 8p. In: Goldstein DR, editor. Science and statistics: A festschrift for Terry Speed. Beachwood, OH: Institute of Mathematical Statistics. pp 237-245.
    • Broman KW, Matsumoto N, Giglio S, Martin CL, Roseberry JA, Zuffardi O, Ledbetter DH, Weber JL. 2003. Common long human inversion polymorphism on chromosome 8p. In: Goldstein DR, editor. Science and statistics: A festschrift for Terry Speed. Beachwood, OH: Institute of Mathematical Statistics. pp 237-245.
  • 10
    • 33847269110 scopus 로고    scopus 로고
    • Size matters: The unexpected challenge of detecting linkage in large cohorts
    • Brzustowicz LM. 2007. Size matters: The unexpected challenge of detecting linkage in large cohorts. Am J Psychiatry 164(2):192-194.
    • (2007) Am J Psychiatry , vol.164 , Issue.2 , pp. 192-194
    • Brzustowicz, L.M.1
  • 12
    • 0031939076 scopus 로고    scopus 로고
    • The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study
    • Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M. 1998. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry 55(1):67-74.
    • (1998) Arch Gen Psychiatry , vol.55 , Issue.1 , pp. 67-74
    • Cannon, T.D.1    Kaprio, J.2    Lonnqvist, J.3    Huttunen, M.4    Koskenvuo, M.5
  • 13
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics
    • Cardno AG, Gottesman II. 2000. Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics. Am J Med Genet 97(1):12-17.
    • (2000) Am J Med Genet , vol.97 , Issue.1 , pp. 12-17
    • Cardno, A.G.1    Gottesman II2
  • 14
    • 33746561166 scopus 로고    scopus 로고
    • Accommodating chromosome inversions in linkage analysis
    • Chen GK, Slaten E, Ophoff RA, Lange K. 2006. Accommodating chromosome inversions in linkage analysis. Am J Hum Genet 79(2):238-251.
    • (2006) Am J Hum Genet , vol.79 , Issue.2 , pp. 238-251
    • Chen, G.K.1    Slaten, E.2    Ophoff, R.A.3    Lange, K.4
  • 16
    • 33645774209 scopus 로고    scopus 로고
    • An integrated genetic map for linkage analysis
    • Duffy DL. 2006. An integrated genetic map for linkage analysis. Behav Genet 36(1):4-6.
    • (2006) Behav Genet , vol.36 , Issue.1 , pp. 4-6
    • Duffy, D.L.1
  • 17
    • 0026774331 scopus 로고
    • Inter- and intrafamilial heterogeneity: Effective sampling strategies and comparison of analysis methods
    • Durner M, Greenberg DA, Hodge SE. 1992. Inter- and intrafamilial heterogeneity: Effective sampling strategies and comparison of analysis methods. Am J Hum Genet 51(4):859-870.
    • (1992) Am J Hum Genet , vol.51 , Issue.4 , pp. 859-870
    • Durner, M.1    Greenberg, D.A.2    Hodge, S.E.3
  • 18
    • 0030731662 scopus 로고    scopus 로고
    • Effect of genetic heterogeneity and assortative mating on linkage analysis: A simulation study
    • Falk CT. 1997. Effect of genetic heterogeneity and assortative mating on linkage analysis: A simulation study. Am J Hum Genet 61(5):1169-1178.
    • (1997) Am J Hum Genet , vol.61 , Issue.5 , pp. 1169-1178
    • Falk, C.T.1
  • 19
    • 0042387796 scopus 로고    scopus 로고
    • Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22
    • Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, Pulver AE. 2003. Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22. Am J Hum Genet 73(3):601-611.
    • (2003) Am J Hum Genet , vol.73 , Issue.3 , pp. 601-611
    • Fallin, M.D.1    Lasseter, V.K.2    Wolyniec, P.S.3    McGrath, J.A.4    Nestadt, G.5    Valle, D.6    Liang, K.Y.7    Pulver, A.E.8
  • 21
    • 0027483312 scopus 로고
    • Distribution of the admixture test for the detection of linkage under heterogeneity
    • Faraway JJ. 1993. Distribution of the admixture test for the detection of linkage under heterogeneity. Genet Epidemiol 10(1):75-83.
    • (1993) Genet Epidemiol , vol.10 , Issue.1 , pp. 75-83
    • Faraway, J.J.1
  • 22
    • 28144431981 scopus 로고    scopus 로고
    • Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13
    • Ferreira MA, O'Gorman L, Le Souef P, Burton PR, Toelle BG, Robertson CF, Visscher PM, Martin NG, Duffy DL. 2005. Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13. Am J Hum Genet 77(6):1075-1085.
    • (2005) Am J Hum Genet , vol.77 , Issue.6 , pp. 1075-1085
    • Ferreira, M.A.1    O'Gorman, L.2    Le Souef, P.3    Burton, P.R.4    Toelle, B.G.5    Robertson, C.F.6    Visscher, P.M.7    Martin, N.G.8    Duffy, D.L.9
  • 23
    • 0035186190 scopus 로고    scopus 로고
    • A study comparing precision of the maximum multipoint heterogeneity LOD statistic to three model-free multipoint linkage methods
    • Finch SJ, Chen CH, Gordon D, Mendell NR. 2001. A study comparing precision of the maximum multipoint heterogeneity LOD statistic to three model-free multipoint linkage methods. Genet Epidemiol 21(4):315-325.
    • (2001) Genet Epidemiol , vol.21 , Issue.4 , pp. 315-325
    • Finch, S.J.1    Chen, C.H.2    Gordon, D.3    Mendell, N.R.4
  • 24
    • 1542373634 scopus 로고    scopus 로고
    • Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information
    • Fingerlin TE, Boehnke M, Abecasis GR. 2004. Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet 74(3):432-443.
    • (2004) Am J Hum Genet , vol.74 , Issue.3 , pp. 432-443
    • Fingerlin, T.E.1    Boehnke, M.2    Abecasis, G.R.3
  • 25
    • 0035575503 scopus 로고    scopus 로고
    • Schizophrenia spectrum disorders: An autosomal-wide scan in multiplex pedigrees
    • Garver DL, Holcomb J, Mapua FM, Wilson R, Barnes B. 2001. Schizophrenia spectrum disorders: An autosomal-wide scan in multiplex pedigrees. Schizophr Res 52(3):145-160.
    • (2001) Schizophr Res , vol.52 , Issue.3 , pp. 145-160
    • Garver, D.L.1    Holcomb, J.2    Mapua, F.M.3    Wilson, R.4    Barnes, B.5
  • 26
    • 0033926130 scopus 로고    scopus 로고
    • Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations
    • Goddard KA, Hopkins PJ, Hall JM, Witte JS. 2000. Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet 66(1):216-234.
    • (2000) Am J Hum Genet , vol.66 , Issue.1 , pp. 216-234
    • Goddard, K.A.1    Hopkins, P.J.2    Hall, J.M.3    Witte, J.S.4
  • 27
    • 0026664045 scopus 로고
    • Detection of linkage under heterogeneity: Comparison of the two-locus vs. admixture models
    • Goldin LR. 1992. Detection of linkage under heterogeneity: Comparison of the two-locus vs. admixture models. Genet Epidemiol 9(1):61-66.
    • (1992) Genet Epidemiol , vol.9 , Issue.1 , pp. 61-66
    • Goldin, L.R.1
  • 28
    • 0027440662 scopus 로고
    • Two-locus models of disease: Comparison of likelihood and nonparametric linkage methods
    • Goldin LR, Weeks DE. 1993. Two-locus models of disease: Comparison of likelihood and nonparametric linkage methods. Am J Hum Genet 53(4):908-915.
    • (1993) Am J Hum Genet , vol.53 , Issue.4 , pp. 908-915
    • Goldin, L.R.1    Weeks, D.E.2
  • 29
    • 0035186189 scopus 로고    scopus 로고
    • Determining trait locus position from multipoint analysis: Accuracy and power of three different statistics
    • Greenberg DA, Abreu PC. 2001. Determining trait locus position from multipoint analysis: Accuracy and power of three different statistics. Genet Epidemiol 21(4):299-314.
    • (2001) Genet Epidemiol , vol.21 , Issue.4 , pp. 299-314
    • Greenberg, D.A.1    Abreu, P.C.2
  • 30
    • 0032231937 scopus 로고    scopus 로고
    • The power to detect linkage in complex disease by means of simple LOD-score analyses
    • Greenberg DA, Abreu P, Hodge SE. 1998. The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet 63(3):870-879.
    • (1998) Am J Hum Genet , vol.63 , Issue.3 , pp. 870-879
    • Greenberg, D.A.1    Abreu, P.2    Hodge, S.E.3
  • 31
    • 0034793123 scopus 로고    scopus 로고
    • Clustering of pedigrees using marker allele frequencies: Impact on linkage analysis
    • Grigull J, Alexandrova R, Paterson AD. 2001. Clustering of pedigrees using marker allele frequencies: Impact on linkage analysis. Genet Epidemiol 21 (Suppl 1):S61-S66.
    • (2001) Genet Epidemiol , vol.21 , Issue.SUPPL. 1
    • Grigull, J.1    Alexandrova, R.2    Paterson, A.D.3
  • 32
    • 0035089756 scopus 로고    scopus 로고
    • Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23
    • Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, et al. 2001. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68(3):661-673.
    • (2001) Am J Hum Genet , vol.68 , Issue.3 , pp. 661-673
    • Gurling, H.M.1    Kalsi, G.2    Brynjolfson, J.3    Sigmundsson, T.4    Sherrington, R.5    Mankoo, B.S.6    Read, T.7    Murphy, P.8    Blaveri, E.9    McQuillin, A.10
  • 33
    • 0031019267 scopus 로고    scopus 로고
    • Magnitude of type I error when single-locus linkage analysis is maximized over models: A simulation study
    • Hodge SE, Abreu PC, Greenberg DA. 1997. Magnitude of type I error when single-locus linkage analysis is maximized over models: A simulation study. Am J Hum Genet 60(1):217-227.
    • (1997) Am J Hum Genet , vol.60 , Issue.1 , pp. 217-227
    • Hodge, S.E.1    Abreu, P.C.2    Greenberg, D.A.3
  • 34
    • 26944493073 scopus 로고    scopus 로고
    • The importance of modelling heterogeneity in complex disease: Application to NIMH Schizophrenia Genetics Initiative data
    • Holliday E, Mowry B, Chant D, Nyholt D. 2005. The importance of modelling heterogeneity in complex disease: Application to NIMH Schizophrenia Genetics Initiative data. Hum Genet 117:160-167.
    • (2005) Hum Genet , vol.117 , pp. 160-167
    • Holliday, E.1    Mowry, B.2    Chant, D.3    Nyholt, D.4
  • 35
    • 0027529253 scopus 로고
    • Asymptotic properties of affected-sib-pair linkage analysis
    • Holmans P. 1993. Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52(2):362-374.
    • (1993) Am J Hum Genet , vol.52 , Issue.2 , pp. 362-374
    • Holmans, P.1
  • 36
    • 0035089146 scopus 로고    scopus 로고
    • Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: Single data set and multiple data set applications
    • Huang J, Vieland VJ. 2001a. Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: Single data set and multiple data set applications. Hum Hered 51(4):217-225.
    • (2001) Hum Hered , vol.51 , Issue.4 , pp. 217-225
    • Huang, J.1    Vieland, V.J.2
  • 37
    • 0035162422 scopus 로고    scopus 로고
    • The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait
    • Huang J, Vieland VJ. 2001b. The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait. Hum Hered 52(4):217-222.
    • (2001) Hum Hered , vol.52 , Issue.4 , pp. 217-222
    • Huang, J.1    Vieland, V.J.2
  • 40
    • 0002906377 scopus 로고
    • The biologic and adoptive families of adopted individuals who became schizophrenic: Prevalence of mental illness and other characteristics
    • Wynne LC, Cromwell RL, Matthysse S, editors, New York: Wiley. pp
    • Kety SS, Rosenthal D, Wender PH, Schulsinger F, Jacobsen B. 1978. The biologic and adoptive families of adopted individuals who became schizophrenic: Prevalence of mental illness and other characteristics. In: Wynne LC, Cromwell RL, Matthysse S, editors. The nature of schizophrenia: New approaches to research and treatment. New York: Wiley. pp 25-37.
    • (1978) The nature of schizophrenia: New approaches to research and treatment , pp. 25-37
    • Kety, S.S.1    Rosenthal, D.2    Wender, P.H.3    Schulsinger, F.4    Jacobsen, B.5
  • 41
    • 0030728925 scopus 로고    scopus 로고
    • Allele-sharing models: LOD scores and accurate linkage tests
    • Kong A, Cox NJ. 1997. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61(5):1179-1188.
    • (1997) Am J Hum Genet , vol.61 , Issue.5 , pp. 1179-1188
    • Kong, A.1    Cox, N.J.2
  • 43
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 44
    • 0024190141 scopus 로고
    • Programs for pedigree analysis: MENDEL, FISHER, and dGENE
    • Lange K, Weeks D, Boehnke M. 1988. Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 5(6):471-472.
    • (1988) Genet Epidemiol , vol.5 , Issue.6 , pp. 471-472
    • Lange, K.1    Weeks, D.2    Boehnke, M.3
  • 47
    • 0028134880 scopus 로고
    • Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Special Issue: Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative
    • Nurnberger JI Jr, Blehar MC, Kaufmann CA, York Cooler C, Simpson SG, Harkavy Friedman J, Severe JB, Malaspina D, Reich T. 1994. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Special Issue: Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51:849-859.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 849-859
    • Nurnberger Jr, J.I.1    Blehar, M.C.2    Kaufmann, C.A.3    York Cooler, C.4    Simpson, S.G.5    Harkavy Friedman, J.6    Severe, J.B.7    Malaspina, D.8    Reich, T.9
  • 51
    • 0036440770 scopus 로고    scopus 로고
    • Evaluating genetic heterogeneity in complex disorders
    • Pal DK, Greenberg DA. 2002. Evaluating genetic heterogeneity in complex disorders. Hum Hered 53(4):216-226.
    • (2002) Hum Hered , vol.53 , Issue.4 , pp. 216-226
    • Pal, D.K.1    Greenberg, D.A.2
  • 52
    • 0035668447 scopus 로고    scopus 로고
    • Effect of misspecification of gene frequency on the two-point LOD score
    • Pal DK, Durner M, Greenberg DA. 2001. Effect of misspecification of gene frequency on the two-point LOD score. Eur J Hum Genet 9(11):855-859.
    • (2001) Eur J Hum Genet , vol.9 , Issue.11 , pp. 855-859
    • Pal, D.K.1    Durner, M.2    Greenberg, D.A.3
  • 54
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard JK, Stephens M, Donnelly P. 2000. Inference of population structure using multilocus genotype data. Genetics 155(2):945-959.
    • (2000) Genetics , vol.155 , Issue.2 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 55
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multilocus models
    • Risch N. 1990. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46(2):222-228.
    • (1990) Am J Hum Genet , vol.46 , Issue.2 , pp. 222-228
    • Risch, N.1
  • 56
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 59
    • 0002710362 scopus 로고
    • Problems of replicating linkage claims in psychiatry
    • Gershon ES, Cloninger CR, editors, Washington, DC: American Psychiatric Press. pp
    • Suarez BK, Hampe CL, Van Eerdewegh P. 1994. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR, editors. Genetic approaches to mental disorders. Washington, DC: American Psychiatric Press. pp 23-46.
    • (1994) Genetic approaches to mental disorders , pp. 23-46
    • Suarez, B.K.1    Hampe, C.L.2    Van Eerdewegh, P.3
  • 60
    • 31544444484 scopus 로고    scopus 로고
    • Genomewide linkage scan of 409 European-Ancestry and African American families with schizophrenia: Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    • Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, et al. 2006. Genomewide linkage scan of 409 European-Ancestry and African American families with schizophrenia: Suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet 78(2):315-333.
    • (2006) Am J Hum Genet , vol.78 , Issue.2 , pp. 315-333
    • Suarez, B.K.1    Duan, J.2    Sanders, A.R.3    Hinrichs, A.L.4    Jin, C.H.5    Hou, C.6    Buccola, N.G.7    Hale, N.8    Weilbaecher, A.N.9    Nertney, D.A.10
  • 61
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • Sullivan PF, Kendler KS, Neale MC. 2003. Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60(12):1187-1192.
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.12 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 64
    • 0032231376 scopus 로고    scopus 로고
    • Bayesian linkage analysis, or: How I learned to stop worrying and love the posterior probability of linkage
    • Vieland VJ. 1998. Bayesian linkage analysis, or: How I learned to stop worrying and love the posterior probability of linkage. Am J Hum Genet 63(4):947-954.
    • (1998) Am J Hum Genet , vol.63 , Issue.4 , pp. 947-954
    • Vieland, V.J.1
  • 65
    • 0036128126 scopus 로고    scopus 로고
    • HLODs, trait models, and ascertainment: Implications of admixture for parameter estimation and linkage detection
    • Vieland VJ, Logue M. 2002. HLODs, trait models, and ascertainment: Implications of admixture for parameter estimation and linkage detection. Hum Hered 53(1):23-35.
    • (2002) Hum Hered , vol.53 , Issue.1 , pp. 23-35
    • Vieland, V.J.1    Logue, M.2
  • 66
    • 0035089255 scopus 로고    scopus 로고
    • Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: Comparative evaluation of model-based linkage methods for affected sib pair data
    • Vieland VJ, Wang K, Huang J. 2001. Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: Comparative evaluation of model-based linkage methods for affected sib pair data. Hum Hered 51(4):199-208.
    • (2001) Hum Hered , vol.51 , Issue.4 , pp. 199-208
    • Vieland, V.J.1    Wang, K.2    Huang, J.3
  • 68
    • 0029737799 scopus 로고    scopus 로고
    • Genome scanning for linkage: An overview
    • Whittemore AS. 1996. Genome scanning for linkage: An overview. Am J Hum Genet 59(3):704-716.
    • (1996) Am J Hum Genet , vol.59 , Issue.3 , pp. 704-716
    • Whittemore, A.S.1
  • 69
    • 0028301661 scopus 로고
    • A class of tests for linkage using affected pedigree members
    • Whittemore AS, Halpern J. 1994. A class of tests for linkage using affected pedigree members. Biometrics 50(1):118-127.
    • (1994) Biometrics , vol.50 , Issue.1 , pp. 118-127
    • Whittemore, A.S.1    Halpern, J.2
  • 70
    • 0035128325 scopus 로고    scopus 로고
    • Problems in the definition, interpretation, and evaluation of genetic heterogeneity
    • Whittemore AS, Halpern J. 2001. Problems in the definition, interpretation, and evaluation of genetic heterogeneity. Am J Hum Genet 68(2):457-465.
    • (2001) Am J Hum Genet , vol.68 , Issue.2 , pp. 457-465
    • Whittemore, A.S.1    Halpern, J.2
  • 71
    • 0036842918 scopus 로고    scopus 로고
    • Evaluating the results of genomewide linkage scans of complex traits by locus counting
    • Wiltshire S, Cardon LR, McCarthy MI. 2002. Evaluating the results of genomewide linkage scans of complex traits by locus counting. Am J Hum Genet 71(5):1175-1182.
    • (2002) Am J Hum Genet , vol.71 , Issue.5 , pp. 1175-1182
    • Wiltshire, S.1    Cardon, L.R.2    McCarthy, M.I.3
  • 72
    • 33847337446 scopus 로고    scopus 로고
    • Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
    • Yamada K, Gerber DJ, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Aruga J, Minabe Y, Tonegawa S, Yoshikawa T. 2007. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci USA 104(8):2815-2820.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.8 , pp. 2815-2820
    • Yamada, K.1    Gerber, D.J.2    Iwayama, Y.3    Ohnishi, T.4    Ohba, H.5    Toyota, T.6    Aruga, J.7    Minabe, Y.8    Tonegawa, S.9    Yoshikawa, T.10
  • 73
    • 12744274510 scopus 로고    scopus 로고
    • Heterogeneity testing in meta-analysis of genome searches
    • Zintzaras E, Ioannidis JP. 2005. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28(2):123-137.
    • (2005) Genet Epidemiol , vol.28 , Issue.2 , pp. 123-137
    • Zintzaras, E.1    Ioannidis, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.