Evaluating the results of genomewide linkage scans of complex traits by locus counting

American Journal of Human Genetics

Volumn 71, Issue 5, 2002, Pages 1175-1182

  Wiltshire, Steven ^a,b   Cardon, Lon R ^b   McCarthy, Mark I ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; DATA ANALYSIS; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOME; GENOTYPE; HUMAN; INHERITANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 0036842918     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/342976     Document Type: Article

References (21)

1. Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M (2001) Genomewide scans of complex human disease: True linkage is hard to find. Am J Hum Genet 69:936-950
2. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL (1998) Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 63:861-869
3. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136
4. Dib C, Fauré S, Fizames C, Samson D, Druout N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J (1996) A comprehensive genetic map of the human genome based on 5,264 micro-satellites. Nature 380:152-154
5. Douglas JA, Boehnke M, Lange K (2000) A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Am J Hum Genet 66:1287-1297
6. Gordon D, Leal SM, Heath SC, Ott J (2000) An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: Implications for study design. Pac Symp Biocomput 663-674
7. Gudbjartsson DF, Jonasson K, Frigge ML, Kong CA (2000) Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13
8. Hirschhorn JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, Burtt NP, Altshuler D, Parker A, Rioux JD, Platko J, Gaudet D, Hudson TJ, Groop LC, Lander ES (2001) Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet 69:106-116
9. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175
10. Hsieh C-L, Oakley-Girvan I, Balise RR, Halpern J, Gallagher RP, Wu AH, Kolonel LN, O'Brien LE, Lin IG, Van Den Berg DJ, Teh C-Z, West DW, Whittemore AS (2001) A genome screen of families with multiple cases of prostate cancer: Evidence of genetic heterogeneity. Am J Hum Genet 69:148-158
11. Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188
12. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
13. Lernmark A, Ott J (1998) Sometimes it's hot, sometimes it's not. Nat Genet 19:213-214
14. Lindholm E, Ekholm B, Shaw S, Jalonen P, Johansson G, Pettersson U, Sherrington R, Adolfsson R, Jazin E (2001) A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet 69:96-105
15. Nicolae DL, Cox NJ (2002) MERLIN ⋯ and the geneticist's stone? Nat Genet 30:3-4
16. Ott J (1999) Analysis of Human Genetic Linkage. The Johns Hopkins University Press, Baltimore
17. Ross S (1988) A First Course in Probability. Macmillan, New York
18. Sawcer S, Jones HB, Judge D, Visser F, Compston A, Good-fellow PN, Clayton D (1997) Empirical genome-wide significance levels established by whole genome simulations. Genet Epidemiol 14:223-229
19. Weiss KM, Terwilliger JD (2000) How many diseases does it take to map a gene with SNPs? Nat Genet 26:151-157
20. Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher G, Groves CJ, Jones E, Prestwich P, Simecek N, Subba Rao PV, Wishart M, Foxon R, Howell S, Smedley S, Cardon LR, Menzel S, McCarthy MI (2001) A genomewide scan for loci predisposing to type 2 diabetes in a UK population (The Diabetes UK Warren 2 Repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569
21. Witte JS, Elston RC, Schork NJ (1996) Genetic dissection of complex traits. Nat Genet 12:355-356