Bayesian linkage analysis, or: How I learned to stop worrying and love the posterior probability of linkage

American Journal of Human Genetics

Volumn 63, Issue 4, 1998, Pages 947-954

  Vieland, Veronica J ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAYES THEOREM; CALCULATION; GENETIC LINKAGE; GENETIC MODEL; PRIORITY JOURNAL; PROBABILITY; REVIEW; STATISTICAL ANALYSIS;

EID: 0032231376     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302076     Document Type: Article

References (28)

1. Clerget-Darpoux F, Bonaïti-Pellié C, Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399
2. Edwards AWF (1972) Likelihood. Cambridge University Press, London
3. Edwards W, Lindman H, Savage LJ (1963) Bayesian statistical inference for psychological research. In: Neyman J (ed) Proceedings of the Third Berkeley Symposium on Mathematical Statistics and Probability. University of California Press, Berkeley
4. Elston RC (1989) Man bites dog? The validity of maximizing lod scores to determine mode of inheritance. Am J Med Genet 34:487-488
5. _ (1994) P values, power, and pitfalls in the linkage analysis of psychiatric disorders. In: Gershon ES, Coninger CR (eds) Genetic approaches to mental disorders. American Psychiatric Press, Washington, DC
6. _ (1997) Algorithms and inferences: the challenge of multifactorial diseases. Am J Hum Genet 60:255-262
7. Elston RC, Lange K (1975) The prior probability of autosomal linkage. Ann Hum Genet 38:341-350
8. Ewens WJ, Shute NC (1986) A resolution of the ascertainment problem. I. Theory. Theor Popul Biol 30:388-12
9. Feller W (1968) An introduction to probability theory and its applications. Vol 1, 3d ed. John Wiley & Sons, New York
10. Genin E, Martinez M, Clerget-Darpoux F (1995) Posterior probability of linkage and maximal lod score. Ann Hum Genet 59:123-132
11. Greenberg DA, Abreu P, Hodge SE (1998a) The power to detect linkage in complex disease by means of simple LODscore analyses. Am J Hum Genet 63:870-879
12. _ (1996) Affecteds-only linkage methods are not a panacea. Am J Hum Genet 58:892-895
13. _ (1998b) Power, mode of inheritance, and type I error in lod scores and affecteds-only methods: reply to Kruglyak. Am J Hum Genet 62:202-204
14. Hacking I (1965) Logic of statistical inference. Cambridge University Press, London
15. Hauser ER, Boehnke M (1993) The posterior probability of linkage Am J Hum Genet Suppl 53:1012
16. Hodge SE, Elston RC (1994) Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet Epidemiol 11:329-342
17. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
18. Morton NE ( 1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277-318
19. _ (1998) Significance levels in complex inheritance. Am J Hum Genet 62:690-697
20. Royall R (1997) Statistical evidence: a likelihood paradigm. Chapman & Hall, New York
21. Schaid DJ (1998) Transmission disequilibrium, family controls, and great expectations. Am J Hum Genet 63:935-941 (in this issue)
22. Smith CAB (1959) Some comments on the statistical methods used in linkage investigations. AmJ Hum Genet 11:289-304
23. Smith CAB, Sturt E (1976) The peak of the likelihood curve in linkage testing. Ann Hum Genet 39:423-426
24. Stuart A, Ord JK (1987) Distribution theory. Vol 1, 5th ed. In: Kendall's advanced theory of statistics. Oxford University Press, New York
25. Suarez BK, Hampe CL, Van Eerdewegh P (1994) Problems of replicating linkage claims in psychiatry. In: Gershon ES, Coninger CR (eds) Genetic approaches to mental disorders. Am Psychiatric Press, Washington, DC
26. Thomas DC, Richardson S, Gauderman J, Pitkäniemi J (1997) A Bayesian approach to multipoint mapping in nuclear families. Genet Epidemiol 14:903-908
27. Vieland VJ, Hodge SE (1996) The problem of ascertainment for linkage analysis. Am J Hum Genet 58:1072-1084
28. _ (1998) Statistical Evidence: A Likelihood Paradigm, by Richard Royall (review). Am J Hum Genet 63:283-289