Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: Single data set and multiple data set applications

Human Heredity

Volumn 51, Issue 4, 2001, Pages 217-225

  Huang, Jian ^a   Vieland, Veronica J ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Locus heterogeneity; Model based test; Model free test; Multiple samples

Indexed keywords

ARTICLE; GENE LOCUS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MODEL; MAXIMUM LIKELIHOOD METHOD; QUANTITATIVE GENETICS; SIBLING; STATISTICAL ANALYSIS; VARIANCE;

CHROMOSOME MAPPING; DATA INTERPRETATION, STATISTICAL; GENETIC HETEROGENEITY; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MODELS, GENETIC; MODELS, STATISTICAL;

GENETTA;

EID: 0035089146     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053345     Document Type: Article

References (24)

1. An autosomal genomic screen for autism
2. A comparison of sib-pair linkage tests for disease susceptibility loci
3. On the distribution of the likelihood ratio
4. Effects of misspecifying genetic parameters in lod score analysis
5. Man bites dog? The validity of maximizing lod scores to determine mode of inheritance
6. Inferring mode of inheritance by comparison of lod scores
7. Linkage analysis under 'random' and 'genetic' reduced penetrance
8. Exact Elods and exact power for affected sib pairs analyzed for linkage under simple right and wrong models
9. Lods, wrods, and mods: The interpretation of lod scores calculated under different models
10. Asymptomatic properties of affected-sib-pair linkage analysis
11. A full genome screen for autism with evidence for linkage to a region on chromosome 7q
12. Linkage analysis in nuclear families. II. Relationship between affected sib-pair tests and lod score analysis
13. Composite likelihood methods
14. Genome-wide scan for autism susceptibility genes
15. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs
16. A genomic screen of autism: Evidence for a multilocus etiology
17. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis
18. Homogeneity test for linkage data
19. The generalized sib pair IBD distribution: Its use in the detection of linkage
20. Adequacy of single-locus approximations for linkage analyses of oligogenic traits
21. Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: Comparative evaluation of model-based linkage methods for ASP data
22. Genome scanning for linkage: An overview