Effect of genetic heterogeneity and assortative mating on linkage analysis: A simulation study

American Journal of Human Genetics

Volumn 61, Issue 5, 1997, Pages 1169-1178

  Falk, Catherine T ^a  

^a NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASSORTATIVE MATING; COMPUTER SIMULATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC LINKAGE; HUMAN; PRIORITY JOURNAL;

EID: 0030731662     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301591     Document Type: Article

References (26)

1. Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399
2. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, et al (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136
3. Durner M, Greenberg DA, Hodge SE (1992) Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet 51:859-870
4. Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325: 783-787
5. Falk CT (1971) The combined effects of positive assortative mating and selection. Heredity 27:125-136
6. _ (1993) Effective strategies for linkage analysis of genetically heterogeneous traits. Am J Hum Genet Suppl 53: 65
7. Goldin LR (1992) Detection of linkage under heterogeneity: comparison of the two-locus vs. admixture models. Genet Epidemiol 9:61-66
8. Goldin LR, Weeks DE (1993) Two-locus models of disease: comparison of likelihood and nonparametric linkage methods. Am J Hum Genet 53:908-915
9. Greenberg DA (1990) Linkage analysis assuming a single-locus mode of inheritance for traits determined by two loci: inferring mode of inheritance and estimating penetrance. Genet Epidemiol 7:467-479
10. Greenberg DA, Hodge SE (1989) Linkage analysis under "random" and "genetic" reduced penetrance. Genet Epidemiol 6: 259-264
11. Hodge SE (1992) Do bilineal pedigrees represent a problem for linkage analysis? Basic principles and simulation results for single-gene diseases with no heterogeneity. Genet Epidemiol 9:191-206
12. Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, et al (1989) Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342:238-243
13. Merikangas KR (1982) Assortative mating for psychiatric disorders and psychological traits. Arch Gen Psychiatry 39: 1173-1180
14. O'Donald P (1960) Assortive mating in a population in which two alleles are segregating. Heredity 15:389-396
15. Ott J (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet 26: 588-597
16. _ (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28:528-529
17. _ (1983) Linkage analysis and family classification under heterogeneity. Ann Hum Genet 47:311-320
18. _ (1984) Analysis of human genetic linkage, 1st ed. Johns Hopkins University Press, Baltimore
19. Risch N, Giuffra L (1992) Model misspecification and multipoint linkage analysis. Hum Hered 42:77-92
20. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993) Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet 53:1127-1136
21. Spence MA, Bishop DT, Boehnke M, Elston RC, Falk C, Hodge SE, Ott J, et al (1993) Methodological issues in linkage analyses for psychiatric disorders: secular trends, assortative mating, bilineal pedigrees: report of the MacArthur Foundation Network I Task Force on Methodological Issues. Hum Hered 43:166-172
22. Sribney WM, Swift M (1992) Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci. Am J Hum Genet 51:773-784
23. Vieland VJ, Greenberg DA, Hodge SE (1993) Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures. Hum Hered 43:329-336
24. Vieland V, Greenberg DA, Hodge SE, Ott J (1992a) Linkage analysis of two-locus diseases under single-locus and two-locus analysis models. In: MacCluer JW, Chakravarti A, Cox D, Bishop DT, Bale SJ, Skolnick MH (eds) Genetic Analysis Workshop 7: issues in gene mapping and detection of major genes. Cytogenet Cell Genet 59:145-146
25. Vieland VJ, Hodge SE, Greenberg DA (1992b) Adequacy of single-locus approximations for linkage analyses of oligogenic traits. Genet Epidemiol 9:45-59
26. Weeks DE, Lange K (1988) The affected-pedigree-member method of linkage analysis. Am J Hum Genet 42:315-326