The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait

Human Heredity

Volumn 52, Issue 4, 2001, Pages 217-222

  Huang, Jian ^a   Vieland, Veronica J ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Heterogeneity lod score; Mixture of 2 distributions; Trait model

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MODEL; GENETIC VARIABILITY; HUMAN; PEDIGREE; QUANTITATIVE TRAIT; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; DATA INTERPRETATION, STATISTICAL; GENETIC HETEROGENEITY; HUMANS; LINKAGE (GENETICS); LOD SCORE; MATHEMATICS; MODELS, GENETIC; MODELS, STATISTICAL; QUANTITATIVE TRAIT, HERITABLE;

EID: 0035162422     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053379     Document Type: Article

References (26)

1. Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases
2. A comparison of sib-pair linkage tests for disease susceptibility loci
3. On the distribution of the likelihood ratio
4. Asymptotic distribution of the likelihood ratio test that a mixture of two binomials is a single binomial
5. Effects of misspecifying genetic parameters in lod score analysis
6. Inter- and intrafamilial heterogeneity: Effective strategies and comparison of analysis methods
7. Man bites dog? The validity of maximizing lod scores to determine mode of inheritance
8. A resolution of the ascertainment sampling problem
9. Distribution of the admixture test for the detection of linkage under heterogeneity
10. Detection of linkage under heterogeneity: Comparison of the two-locus vs. admixture models
11. Genetic heterogeneity and other complex models: A problem for linkage detection
12. Two-locus models of disease: Comparison of likelihood and nonparametric linkage methods
13. The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): Linkage studies, two-locus models, and genetic heterogeneity
14. Asymptomatic properties of affected- sib-pair linkage analysis
15. Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: Single data set and multiple data set applications
16. Linkage analysis in nuclear families: II. Relationship between affected sib-pair tests and lod score analysis
17. Power of the linkage test for a heterogeneous disorder due to two independent inherited causes: A simulation study
18. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions
19. Linkage strategies for genetically complex traits: III. The effect of marker polymorphism on analysis of affected relative pairs
20. Homogeneity test for linkage data
21. The generalized sib pair IBD distribution: Its use in the detection of linkage
22. Inherent intractability of the ascertainment problem for pedigree data: A general likelihood framework
23. The problem of ascertainment in linkage analysis
24. Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: A comparative evaluation of model-based linkage methods for affected sib pair data
25. On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified