Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizoprenia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 8, 2007, Pages 2815-2820

  Yamada, Kazuo ^a   Gerber, David J ^b   Iwayama, Yoshimi ^a   Ohnishi, Tetsuo ^a   Ohba, Hisako ^a   Toyota, Tomoko ^a   Aruga, Jun ^a   Minabe, Yoshio ^a,c   Tonegawa, Susumu ^b   Yoshikawa, Takeo ^a,d  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Enhancer; Genetic association; Immediate early gene; Postmortem brain

Indexed keywords

CALCINEURIN; EARLY GROWTH RESPONSE FACTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; ARTICLE; ASIAN; BRAIN TISSUE; CADAVER; CASE CONTROL STUDY; CONTROLLED STUDY; EGR1 GENE; EGR2 GENE; EGR3 GENE; FAMILY STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN TISSUE; IMMEDIATE EARLY GENE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MULTIGENE FAMILY; POPULATION RESEARCH; PPP3CC GENE; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BRAIN; CALCINEURIN; CASE-CONTROL STUDIES; EARLY GROWTH RESPONSE PROTEIN 3; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MULTIGENE FAMILY; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 33847337446     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610765104     Document Type: Article

References (51)

1. Norton N, Williams HJ, Owen MJ (2006) Curr Opin Psychiatry 19:158-164.
2. Collier DA, Li T (2003) Eur J Pharmacol 480:177-184.
3. Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova TD, Zeng H, Caron MG, Tonegawa S (2003) Proc Natl Acad Sci USA 100:8987-8992.
4. Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M, Tonegawa S (2003) Proc Natl Acad Sci USA 100:8993-8998.
5. Groth RD, Dunbar RL, Mermelstein PG (2003) Biochem Biophys Res Commun 311:1159-1171.
6. Shibasaki F, Hallin U, Uchino H (2002) J Biochem (Tokyo) 131:1-15.
7. Greengard P (2001) Biosci Rep 21:247-269.
8. Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot BD, Miyakawa T, Bear MF, Tonegawa S (2001) Cell 107:617-629.
9. Pritchard JK, Stephens M, Donnelly P (2000) Genetics 155:945-959.
10. Yamada K, Hattori E, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Takao H, Minabe Y, Nakatani N, Higuchi T, et al (2006) Biol Psychiatry 60:192-201.
11. Eastwood SL, Burnet PW, Harrison PJ (2005) Biol Psychiatry 57:702-710.
12. O'Donovan KJ, Tourtellotte WG, Millbrandt J, Baraban JM (1999) Trends Neurosci 22:167-173.
13. Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J (1996) Science 273:1219-1221.
14. Tourtellotte WG, Keller-Peck C, Milbrandt J, Kucera J (2001) Dev Biol 232:388-399.
15. Tourtellotte WG, Milbrandt J (1998) Nat Genet 20:87-91.
16. Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (1998) Nat Genet 18:382-384.
17. Manji HK, Gottesman II, Gould TD (2003) Set STKE 2003, pe49.
18. Winder DG, Sweatt JD (2001) Nat Rev Neurosci 2:461-474.
19. Hildeman DA, Mitchell T, Kappler J, Marrack P (2003) J Clin Invest 111:575-581.
20. Safford M, Collins S, Lutz MA, Allen A, Huang CT, Kowalski J, Blackford A, Horton MR, Drake C, Schwartz RH, et al. (2005) Nat Immunol 6:472-480.
21. Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M (2004) Proc Natl Acad Sci USA 101:8180-8185.
22. Decker EL, Skerka C, Zipfel PF (1998) J Biol Chem 273:26923-26930.
23. Arolt V, Rothermundt M, Wandinger KP, Kirchner H (2000) Mol Psychiatry 5:150-158.
24. Villemain F, Chatenoud L, Guillibert E, Pelicier Y, Bach JF (1987) Ann NY Acad Sci 496:669-675.
25. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, et al. (2002) Am J Hum Genet 71:877-892.
26. Corfas G, Roy K, Buxbaum JD (2004) Nat Neurosci 7:575-580.
27. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, Haroutunian V, Fienberg AA (2001) Proc Natl Acad Sci USA 98:4746-4751.
28. Jacobson C, Duggan D, Fischbach G (2004) Proc Natl Acad Sci USA 101:12218-12223.
29. Michailov GV, Sereda MW, Brinkmann BG, Fischer TM, Haug B, Birchmeier C, Role L, Lai C, Schwab MH, Nave KA (2004) Science 304:700-703.
30. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V (2003) Arch Gen Psychiatry 60:443-456.
31. Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA (2004) Nat Genet 36:131-137.
32. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (1999) Science 284:339-343.
33. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Cell 96:857-868.
34. Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, Richardson JA, Hill JA, Olson EN (2002) Proc Natl Acad Sci USA 99:907-912.
35. von der Kammer H, Mayhaus M, Albrecht C, Enderich J, Wegner M, Nitsch RM (1998) J Biol Chem 273:14538-14544.
36. Sarter M, Nelson CL, Bruno JP (2005) Schizophr Bull 31:117-138.
37. Dean B, McLeod M, Keriakous D, McKenzie J, Scarr E (2002) Mol Psychiatry 7:1083-1091.
38. Deng C, Huang XF (2005) J Neurosci Res 81:883-890.
39. Raedler TJ, Knable MB, Jones DW, Urbina RA, Gorey JG, Lee KS, Egan MF, Coppola R, Weinberger DR (2003) Am J Psychiatry 160:118-127.
40. Gerber DJ, Sotnikova TD, Gainetdinov RR, Huang SY, Caron MG, Tonegawa S (2001) Proc Natl Acad Sci USA 98:15312-15317.
41. Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Deng C, Wess J (1999) Proc Natl Acad Sci USA 96:10483-10488.
42. Holmes AJ, MacDonald A, III, Carter CS, Barch DM, Andrew Stenger V, Cohen JD (2005) Schizophr Res 76:199-206.
43. O'Donovan KJ, Levkovitz Y, Ahn D, Baraban JM (2000) J Neurochem 75:1352-1357.
44. Unoki M, Nakamura Y (2003) FEBS Lett 554:67-72.
45. Yasunaga J, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T, Mitsuya H, Matsuoka M (2004) Cancer Res 64:6002-6009.
46. Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, et al. (2005) Biol Psychiatry 57:1493-1503.
47. O'Connell JR, Weeks DE (1998) Am J Hum Genet 63:259-266.
48. Martin ER, Monks SA, Warren LL, Kaplan NL (2000) Am J Hum Genet 67:146-154.
49. Dudbridge F (2003) Genet Epidemiol 25:115-121.
50. Abecasis GR, Cookson WO (2000) Bioinformatics 16:182-183.
51. Torrey EF, Webster M, Knable M, Johnston N, Yolken RH (2000) Schizophr Res 44:151-155.