Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 97, Issue 1, 2000, Pages 12-17

  Cardno, Alastair G ^a   Gottesman, Irving I ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

Epigenetic; Genetic modeling; Heritability; Heterogeneity; Spectrum

Indexed keywords

GENETIC HETEROGENEITY; GENETIC MODEL; HERITABILITY; HUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; TWIN CONCORDANCE; TWIN DISCORDANCE; TWIN ZYGOSITY; GENETICS; STATISTICAL ANALYSIS; TWINS;

DATA INTERPRETATION, STATISTICAL; HUMANS; SCHIZOPHRENIA; TWIN STUDIES;

EID: 0034060459     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U     Document Type: Review

References (48)

1. Berman KF, Torrey EF, Daniel DG, Weinberger DR. 1992. Regional cerebral blood-flow in monozygotic twins discordant and concordant for schizophrenia. Arch Gen Psychiatry 49:927-934.
2. Bertelsen A, Gottesman II. 1995. Schizoaffective psychoses: genetical clues to classification. Am J Med Genet 60:7-11.
3. Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M. 1998. The genetic epidemiology of schizophrenia in a Finnish twin cohort: a population-based modeling study. Arch Gen Psychiatry 55:67-74.
4. Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ, Venturi P, Jones LA, Lewis SW, Sham PC, Gottesman II, Farmer AE, McGuffin P, Reveley AM, Murray RM. 1999. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch Gen Psychiatry 56: 162-168.
5. Cardno AG, Rijsdijk FV, Sham PC, Davies NJ, Murray RM, McGuffin P. Comorbidity between psychotic disorders in the Maudsley twin psychosis series. Submitted.
6. Davis JO, Bracha HS. 1996. Prenatal growth markers in schizophrenia: a monozygotic co-twin control study. Am J Psychiatry 153: 1166-1172.
7. Falconer DS. 1965. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 29:51-76.
8. Farmer AE, McGuffin P, Gottesman II. 1984. Searching for the split in schizophrenia: a twin study perspective. Psychiatr Res 13: 109-118.
9. Farmer AE, McGuffin P, Gottesman II. 1987. Twin concordance for DSM-II schizophrenia: scrutinizing the validity of the definition. Arch Gen Psychiatry 44:634-641.
10. Fischer M. 1973. Genetic and environmental factors in schizophrenia: a study of schizophrenic twins and their families. Acta Psychiatr Scand Suppl 238.
11. Franzek E, Beckmann H. 1998. Different genetic background of schizophrenia spectrum psychoses: a twin study. Am J Psychiatry 155: 76-83.
12. Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, Weinberger DR. 1995. Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr Res 17:77-84.
13. Goldberg TE, Torrey EF, Gold JM, Ragland JD, Bigelow LB, Weinberger DR. 1993. Learning and memory in monozygotic twins discordant for schizophrenia. Psychol Med 23:71-85.
14. Gottesman, II. 1991. Schizophrenia genesis: the origins of madness. Freeman: New York.
15. Gottesman II. 1997. Twins: enroute to QTLs for cognition. Science 276:1522-1523.
16. Gottesman II, Bertelsen A. 1989. Confirming unexpressed genotypes for schizophrenia: risks in offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiatry 46:867-872.
17. Gottesman II, Shields J. 1967. A polygenic theory of schizophrenia. Proc Nat Acad Sci USA 58:199-205.
18. Gottesman II, Shields J. 1972. Schizophrenia and genetics: a twin vantage point. New York: Academic Press.
19. Kendell RE. 1988. Other functional psychoses. In: Kendell RE, Zealley AK, editors. Companion to psychiatric studies, 4th ed. Edinburgh: Churchill Livingstone. p 262-373.
20. Kendler KS. 1983. Overview: a current perspective on twin studies of schizophrenia. Am J Psychiatry 140:1413-1425.
21. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. 1993. The Roscommon family study: I. methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 50:527-540.
22. Kendler KS, Tsuang MT, Hays P. 1987. Age at onset in schizophrenia: a familial perspective. Arch Gen Psychiatry 44:881-890.
23. Kläning U. 1996. Schizophrenia in twins: incidence and risk factors. Unpublished Doctoral dissertation, University of Aarhus, Denmark.
24. Kringlen E, Cramer G. 1989. Offspring of monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 46:873-877.
25. Litman RE, Torrey EF, Hommer DW, Radant AR, Pickar D, Weinberger DR. 1997. A quantitative analysis of smooth pursuit eye tracking in monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 54: 417-426.
26. Markow TA, Gottesman II. 1989. Fluctuating dermatoglyphic asymmetry in psychotic twins. Psychiatr Res 29:37-44.
27. Martin N, Boomsma D, Machin G. 1997. A twin-pronged attack on complex traits. Nat Genet 17:387-392.
28. McGuffin P, Asherson P, Owen M, Farmer A. 1994. The strength of the genetic effect: is there room for an environmental influence in the etiology of schizophrenia? Br J Psychiatry 164:593-599.
29. McGuffin P, Farmer A, Gottesman II. 1987. Is there really a split in schizophrenia? The genetic evidence. Br J Psychiatry 150:581-592.
30. McGuffin P. Farmer AE, Gottesman II, Murray RM, Reveley AM. 1984. Twin concordance for operationally defined schizophrenia: confirmation of familiality and heritability. Arch Gen Psychiatry 41:541-545.
31. McNeil TF, Cantorgraae E, Torrey EF, Sjostrom K, Bowler A. Taylor E, Rawlings R, Higgins ES. 1994. Obstetric complications in histories of monozygotic twins discordant and concordant for schizophrenia. Acta Psychiatr Scand 89:196-204.
32. Murray RM. 1994. Neurodevelopmental schizophrenia: the rediscovery of dementia praecox. Br J Psychiatry 165(suppl 25):6-12.
33. Neale MC. 1999. Mx: statistical modeling, 5th ed. Box 126 MCV, Richmond, VA: Dept. of Psychiatry, Medical College of Virginia.
34. Neale MC, Cardon LR. 1992. Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers.
35. Neale MC, Eaves LJ, Hewitt JK, MacLean CJ, Meyer JM, Kendler KS. 1989. Analyzing the relationship between age at onset and risk to relatives. Am J Hum Genet 45:226-239.
36. Neale MC, Kendler KS. 1995. Models of comorbidity for multifactorial disorders. Am J Hum Genet 57:935-953.
37. Noga JT, Bartley AJ, Jones DW, Torrey EF, Weinberger DR. 1996. Cortical gyral anatomy and gross brain dimensions in monozygotic twins discordant for schizophrenia. Schizophr Res 22:27-40.
38. Ohara K, Xu HD, Matsunaga T, Xu DS, Huang XQ, Gu GF, Ohara K, Wang ZC. 1998. Cerebral ventricle-brain ratio in monozygotic twins discordant and concordant for schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 22:1043-1050.
39. Onstad S, Skre I, Torgersen S, Kringlen E. 1991a. Twin concordance for DSM-III-R schizophrenia. Acta Psychiatr Scand 83:395-401.
40. Onstad S, Skre I, Torgersen S, Kringlen E. 1991b. Subtypes of schizophrenia: evidence from a twin-family study. Acta Psychiatr Scand 84:203-206.
41. Petronis A, Popendikyte V, Paterson AD, Gottesman II, Nobrega J, Macciardi F, Kennedy JL. 1999. Epigenetic differences in genetically identical organisms. Mol Psychiatry 4(suppl 1):S17.
42. Reich T, James JW, Morris CA. 1972. The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Ann Hum Genet 36:163-184.
43. Risch N. 1990. Linkage strategies for genetically complex traits: I. multilocus models. Am J Hum Genet 46:222-228.
44. Stassen HH, Coppola R, Gottesman II, Torrey EF, Kuny S, Rickler KC, Hell D. 1999. EEG differences in monozygotic twins discordant and concordant for schizophrenia. Psychophysiology 36:109-117.
45. Torrey EF, Bowler AE, Taylor EH, Gottesman II. 1994. Schizophrenia and manic depressive disorder: the biological roots of mental illness as revealed by a landmark study of identical twins. New York: Basic Books.
46. Tsujita T, Okazaki Y, Fujimaru K, Minami Y, Mutoh Y, Maeda H, Fukazawa T, Yamashita H, Nakane Y. Twin concordance rate of DSM-III-R schizophrenia in a new Japanese sample. 1992. Abstracts Seventh International Congress on Twin Studies (152). Tokyo, Japan.
47. Vincent JB, Kalsi G, Klempan T, Tatuch Y, Sherrington RP, Breschel T, McInnis MG, Brynjolfsson J, Petursson H, Gurling HMD, Gottesman II, Torrey EF, Petronis A, Kennedy JL. 1998. No evidence of expansion of CAG or GAA repeats in schizophrenia families and monozygotic twins. Hum Genet 103:41-47.
48. Weinberger DR, Berman KF, Suddath R, Torrey EF. 1992. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic-resonance-imaging and regional cerebral blood-flow study of discordant monozygotic twins. Am J Psychiatry 149: 890-897.